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  • 1
    Publication Date: 2013-08-03
    Description: Pathogens dramatically affect host cell transcription programs for their own profit during infection, but in most cases, the underlying mechanisms remain elusive. We found that during infection with the bacterium Listeria monocytogenes, the host deacetylase sirtuin 2 (SIRT2) translocates to the nucleus, in a manner dependent on the bacterial factor InlB. SIRT2 associates with the transcription start site of a subset of genes repressed during infection and deacetylates histone H3 on lysine 18 (H3K18). Infecting cells in which SIRT2 activity was blocked or using SIRT2(-/-) mice resulted in a significant impairment of bacterial infection. Thus, SIRT2-mediated H3K18 deacetylation plays a critical role during infection, which reveals an epigenetic mechanism imposed by a pathogenic bacterium to reprogram its host.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eskandarian, Haig A -- Impens, Francis -- Nahori, Marie-Anne -- Soubigou, Guillaume -- Coppee, Jean-Yves -- Cossart, Pascale -- Hamon, Melanie A -- New York, N.Y. -- Science. 2013 Aug 2;341(6145):1238858. doi: 10.1126/science.1238858.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Unite des Interactions Bacteries-Cellules, Institut Pasteur, Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Animals ; Bacterial Proteins/genetics ; Cell Nucleus/metabolism ; Chromatin/metabolism ; Cytosol/metabolism ; HeLa Cells ; Histones/genetics/*metabolism ; Host-Pathogen Interactions ; Humans ; Listeria monocytogenes/genetics/*pathogenicity ; Listeriosis/*genetics/*metabolism/microbiology ; Lysine/genetics/metabolism ; Membrane Proteins/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Protein Processing, Post-Translational ; Proto-Oncogene Proteins c-met/metabolism ; Sirtuin 2/genetics/*metabolism ; Transcription Initiation Site ; *Transcriptional Activation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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