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  • Bioartificial  (1)
  • Blessed test score  (1)
  • GFAP  (1)
  • GS  (1)
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  • Springer  (3)
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  • Springer  (3)
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  • 1
    ISSN: 1573-6903
    Keywords: Blessed test score ; astrocyte ; classical senile plaque ; βA4 classical deposits
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Glutamine synthetase (GS), a metabolic marker of the mature astrocyte, was investigated in the temporal neocortex of postmortem brain samples of 8 cases, either not demented or affected by senile dementia of the Alzheimer type. A negative correlation between the GS protein level and the density of both classical βA4 deposits and senile plaques was evidenced. Such a correlation for GS underlies a dysfunction of the astroglial metabolism and particularly of the glutamate and ammonia neutralization. Since GS is sensitive to oxidative lesioning, the changes in GS level that were observed, occurring at the posttranslational stage, might reflect oxidative damage and have severe consequences on the pathological cascade of events.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-6903
    Keywords: T3 ; astrocytes ; plasticity ; GFAP ; GS ; mRNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Normal development of the brain requires the presence of thyroid hormones. To progress in the understanding of the contribution of astrocytes to brain pathophysiology we investigated the effect of T3, on the astroglial plasticity through the expression of two astroglial proteins: the Glial fibrillary acidic protein (GFAP) and the glutamine synthetase (GS). Western and northern blots were performed using astroglial primary cultures initiated from neocortex and cerebellum of newborn mice. Treatment with T3 caused a decrease of GFAP and of its encoding message level in both areas, suggesting a transcriptional regulation of its expression, whereas it had no apparent effect on GS expression. This reduction in GFAP expression was developmentally regulated: it was significant in proliferating but not in more mature astrocytes. T3 effect on astrocytes was higher in the cerebellum compared to the neocortex, suggesting the presence of astroglial subpopulations differing by their sensitivity to T3. The astroglial specific response to T3, corresponds to a precise, targetted and regulated adaptation of the cell. Factors of the microenvironment may modulate this specific astroglial response in vivo.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1068
    Keywords: Bone repair ; Biotechnology ; Material science ; Bioartificial ; Osteoconductive ; Osteoinductive
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It is very likely that the need for bone substitutes will increase in the next decade. The present substitutes are generally bioactive and osteoconductive. Glassy or ceramic materials have been used up to now to act as a guide for bone healing tissue and were shown to admit bone apposition at their surface, probably due to the epitaxial growth of carbonated apatite crystals on it. Different forms of bone substitutes have been developed which do not show exactly the same properties. The reaction of bone tissue against bioactive material debris shows major differences from that of polymers or metals.In vitro models were developed to study the interface between bone cells and extracellular matrix, and the surface of bioactive material. Biotechnology makes available some morphogenetic proteins or growth factors in large quantities for combination with osteoconductive material which then can become osteoinductive. Bioartificial bone tissue constituted by a primary osteogenic cell line immobilised at the surface of osteoconductive materials made it possible to obtain osteogenic materials. The ideal bone biomaterial is still to be engineered. The combination of material sciences and molecular biology will help to optimise the next generation of material surfaces.
    Type of Medium: Electronic Resource
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