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  • Biochemistry  (1)
  • Miscellaneous Medical  (1)
  • pararenal spaces  (1)
  • American Association for the Advancement of Science (AAAS)  (1)
  • Wiley-Blackwell  (1)
  • American Association for the Advancement of Science (AAAS)  (1)
  • Wiley-Blackwell  (1)
  • 1
    ISSN: 0897-3806
    Keywords: fasciae ; kidney ; abdomen ; perirenal spaces ; pararenal spaces ; Life and Medical Sciences ; Miscellaneous Medical
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Our objective was to describe the boundaries and sites of communication of the posterior peritoneal compartments in order to explain extensions of pathological processes in retroperitoneal areas. To this end we examined these distinct bilateral compartments [anterior (AP) and posterior (PP) pararenal and perirenal (P) spaces] in four bodies by CT scans, dissections, crosssections, latex injections, and light microscopy. Perirenal areas bilaterally were closed spaces which extended from the inferior surface of the diaphragm to the superior pelvic aperture (pelvic inlet) tapering superiorly and inferiorly in the shape of two cones with a common base at the midrenal area where they communicated across the median plane. The AP is a potential space on the right but contains the pancreas on the left. Each has shorter superior and inferior extensions than the corresponding PP space. Tough, often multilaminar, fasciae surrounded these spaces and limited the spread of injected latex except where vascular pathways permitted inter-compartmental spread. Computer-assisted 3-D reconstructions showed that these spaces extended potentially from the diaphragm into the pelvis. These compartments and their fasciae help explain the predictable yet restricted clinical extensions of pancreatitis, renal infections, and aortic aneurysms in the posterior abdomen.
    Additional Material: 26 Ill.
    Type of Medium: Electronic Resource
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  • 2
    American Association for the Advancement of Science (AAAS)
    In: Science
    Publication Date: 2018-08-10
    Description: The Hedgehog (Hh) pathway involved in development and regeneration is activated by the extracellular binding of Hh to the membrane receptor Patched (Ptch). We report the structures of human Ptch1 alone and in complex with the N-terminal domain of human Sonic hedgehog (ShhN) at resolutions of 3.9 and 3.6 angstroms, respectively, as determined by cryo–electron microscopy. Ptch1 comprises two interacting extracellular domains, ECD1 and ECD2, and 12 transmembrane segments (TMs), with TMs 2 to 6 constituting the sterol-sensing domain (SSD). Two steroid-shaped densities are resolved in both structures, one enclosed by ECD1/2 and the other in the membrane-facing cavity of the SSD. Structure-guided mutational analysis shows that interaction between ShhN and Ptch1 is steroid-dependent. The structure of a steroid binding–deficient Ptch1 mutant displays pronounced conformational rearrangements.
    Keywords: Biochemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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