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  • Biochemistry and Biotechnology  (2)
  • B-CELL LYMPHOMA
  • LYMPHOMA
  • ASSOCIATIONS
  • 1
    Keywords: SPECTRA ; BLOOD ; neoplasms ; CLASSIFICATION ; GENERATION ; RISK ; RNA ; PATIENT ; INFECTION ; LIVER-TRANSPLANTATION ; ASSOCIATION ; antibodies ; antibody ; virus ; NO ; LYMPHOMA ; MALIGNANCIES ; AGE ; etiology ; LYMPHOCYTES ; case-control studies ; PREVALENCE ; immunosuppression ; B-CELL LYMPHOMA ; HEMOPHILIA ; NON-HODGKINS-LYMPHOMA ; ELISA ; MALIGNANCY ; REGRESSION ; ASSOCIATIONS ; GRADE ; HCV ; hepatitis C ; LYMPHOPROLIFERATIVE DISORDERS ; MALIGNANT-LYMPHOMA ; MIXED CRYOGLOBULINEMIA ; REARRANGEMENT ; RECIPIENTS
    Abstract: Hepatitis C virus (HCV) has been implicated in the etiology of malignant lymphomas. We estimated the risk of lymphoma associated with detection of HCV infection. Cases (n = 529) were consecutive patients newly diagnosed with a lymphoid malignancy between 1998 and 2002 in 4 centers in Spain. Lymphomas were diagnosed and classified using the WHO Classification. Controls (n = 600) were hospitalized patients matched to the cases by 5-year age group, gender and study center. Several medical conditions associated with severe immunosuppression precluded the eligibility of controls. Patients underwent a personal interview and blood sampling. HCV positive subjects were considered those with antibody response to third generation ELISA or detection of HCV RNA with Amplicor 2.0. Cases were systematically tested for HIV antibodies. We used the chi(2) test and unconditional logistic regression to estimate the odds ratio (OR) and 95% confidence interval (95%. Cl) for lymphoma associated with HCV. HCV infection was detected in 40 cases (73%) and 23 (3.8%) control subjects. Six of 16 patients with HIV-related lymphomas and 4 of 8 organ-recipient-related lymphomas were HCV positive. The analysis, excluding HIV-infected subjects and organ recipients, led to a prevalence of HCV of 5.9% among cases and 3.8% among controls. The age-, gender- and center-adjusted OR for all lymphomas was 1.58 (95% Cl = 0.89-2.79). Among all lymphoma categories, HCV was associated with an increased risk of low grade B-cell lymphomas not otherwise specified (NOS) (OR = 35.98, 95% Cl = 4.70-275.4). A 2-fold excess risk associated to HCV was observed for marginal B-cell lymphomas, diffuse large B-cell lymphoma and lymphoma B NOS but the associations were not statistically significant. HCV infection is associated with an increased risk of a broad spectrum of lymphoid neoplasms among non severely immunocompromised subjects in Spain. (C) 2004 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 15185347
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  • 2
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The irradiation with visible light of a photosensitizer dye like methylene blue was used to regenerate by electron transfer the oxidized form of a pyridine nucleotide coenzyme (NAD+). The process has been studied on a common enzymatic reaction: ethanol oxidation by alcohol-NAD+ oxidoreductase immobilized on polyacrylamide gel or porous glass balls. In the experimental conditions used, the initial NAD+ recycling rates were 2.33 × 104 cycles/h (polyacrylamide) and 3 × 104 cycles/h (glass balls). A total number of 49.5 × 104 cycles was obtained for 13 runs of 2 h. The enzyme immobilization strongly increased its stability: after 28 days at 20°C, the residual activity was 25% of the initial value.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: By investigating the effects of four operating variables - volume (V), Ultrafiltration flux (J), enzyme concentration (E), and substrate concentration (S) - on capacity (K) and conversion rate (ε) of a hollow fiber CSTR, the performances of the CSTR and the kinetic constants of the reaction were determined. A model which takes into account the course of fractional conversion (X) according to the modified space-time parameter, τ (integrated form of V, J, S, and E), was devised by employing the relationship to integrate the equation for the reaction rate of the CSTR and the expression of the modified space time. Correlation of this model and the experimentally obtained results demonstrates that the characteristics for an ultrafiltration membrane reactor for enzymatic hydrolysis by alcalase of plasma proteins are close to those of an ideal CSTR. Optimal scaling up, however, remains dependent on the compromise which may be obtained between capacity and the conversion rate.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
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