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  • IRRADIATION  (2)
  • radiotherapy  (2)
  • Biomechanical cause  (1)
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  • 1
    Keywords: ENERGIES ; OPTIMIZATION ; IRRADIATION ; radiotherapy ; SURVIVAL ; CELL ; Germany ; MODEL ; THERAPY ; SYSTEM ; PATIENT ; IONS ; treatment ; CARBON ; CELL-SURVIVAL ; REQUIREMENTS ; VERIFICATION ; ENERGY ; NUMBER ; STEPS ; BEAM ; SKULL BASE ; PREDICTION ; treatment planning ; FUTURE ; LIGHT ; SOFTWARE ; REQUIREMENT ; PREDICTIONS ; cell survival ; scanned ion beams
    Abstract: Since 1997 a radiotherapy unit using fast carbon ions is operational at GSI. An intensity-controlled magnetic raster scanner together with a synchrotron allowing fast energy variation enable a unique method of purely active dose shaping in three dimensions. This contribution describes the necessary steps to establish a treatment planning system for this novel modality. We discuss the requirements for the physical beam model and the radiobiological model. Based on these we chose to implement a home-grown pencil beam model to describe the ion-tissue interaction and the Local Effect Model to calculate the RBE voxel-by-voxel. Given the large number of degrees of freedom biological dose optimization must be achieved by means of inverse treatment planning. All ion-related aspects are collected in our TRiP98 software. Biological dosimetry measuring cell survival in two dimensions turns out to be a good way to verify the model predictions as well as the actual irradiation procedure. We show a patient example and outline the future steps towards a dedicated clinic facility for all light ions
    Type of Publication: Journal article published
    PubMed ID: 15971316
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  • 2
    Keywords: ENERGIES ; IRRADIATION ; radiotherapy ; CLINICAL-TRIAL ; COMBINATION ; Germany ; THERAPY ; imaging ; SUPPORT ; SYSTEM ; SYSTEMS ; PATIENT ; IONS ; treatment ; PROTON ; TRIAL ; TRIALS ; DISTRIBUTIONS ; IN-SITU ; ENERGY ; CLINICAL-TRIALS ; BEAM ; DELIVERY ; positron emission tomography ; POSITRON-EMISSION-TOMOGRAPHY ; INTENSITY-MODULATED RADIOTHERAPY ; PET ; CONSTRUCTION ; EUROPE ; OXYGEN ; SECTIONS ; INSITU ; radiology ; WORLDWIDE ; CAPACITY ; THERAPIES ; DOSE DISTRIBUTIONS ; LIBRARIES ; beam scanning ; charged particle ; clinical trials ; heavy ion ; ion gantry ; SCANNING SYSTEM
    Abstract: The ion beam therapy facility presently under construction at the Department of Clinical Radiology, University of Heidelberg, Germany, will be the first dedicated and hospital-based irradiation facility for protons and heavier ions in Europe. A capacity of more than 1000 patient treatments per year is planned. The facility comprises two horizontally-fixed beamlines for patient treatments plus a fixed-beam experimental area. In addition, the world-wide first scanning ion gantry is under construction. The facility fully relies on an active beam delivery method, the intensity-controlled rasterscan technique. The availability of different ion species ranging from protons to oxygen under identical conditions optimally supports clinical trials aiming to clarify the question of which particle species is best suited for the individual indications. A linac-synchrotron combination will deliver libraries of energy-, focus- and intensity-variable pencil-beams for each ion species to the dose-delivering scanning systems at each treatment station. The available energies correspond to water-equivalent ranges from 2 cm to 30 cm. The intensity-controlled rasterscan technique allows for the administration of inversely planned and biologically optimized dose distributions having utmost precision. The facility will be equipped with state-of-the-art imaging modalities as well as an in-situ Positron-Emission-Tomography (PET). The commissioning of the different sections is scheduled for 2006. The pre-clinical operation will start early in 2007 followed by the routine patient treatment
    Type of Publication: Journal article published
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  • 3
    ISSN: 1432-0932
    Keywords: Hemispherical spondylosclerosis ; Biomechanical cause ; Reflection phenomenon ; Mirror-image type ; Two-thirds type
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical and radiological examination of 167 hemispherical spondylosclerosis (HSS) patients (56 male, 111 female) revealed a total of 186 cases of HSS with multiple incidences occurring in 18 patients. Radiologically these HSS cases were characterized by erosion and new bone formation at the inferior and upper end plate of the vertebra below, periosteal bone apposition or ossification of the anterior longitudinal ligament, spondylophytes, and signs of degenerative alteration of the vertebra and disc. In addition, the size and location (anterior, middle, posterior third) of each HSS in the lateral view was investigated. The cases were also investigated for reflection phenomenon between supra- and infradiscal sclerosis and for kyphotic angulation of the two adjacent vertebrae. The results showed that in 105 cases (56.5%) the HSS filled out the entire vertebral area; 97 cases (52.2%) showed a mirror-image type HSS; while in 8 cases (4.3%), the infradiscal sclerosis was polymorphic. In 81 cases (43.5%), the sclerosis was limited to the anterior two-thirds; this is termed “two-thirds” type. All 81 of these cases of HSS showed a kyphotic angulation of at least 4°. Of these, 61 (32.8% of the total) showed reflection phenomenon while 20 (10.7% of the total) had polymorphic infradiscal sclerosis. Overall, 158 cases of HSS (85%) exhibited the reflection phenomenon between supra- and infradiscal sclerosis. whereas 28 cases (15%) revealed polymorphic sclerosis of the subadjacent vertebra. Kyphotic angulation was completely absent when HSS was visible in the entire vertebra. A dorsal gap of the disc space was seen in 36 cases (19.4%). A biomechanical classification of HSS is presented in order to help differentiate between centric and eccentric segmental load transfer.
    Type of Medium: Electronic Resource
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