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    ISSN: 1432-1076
    Keywords: Blood volume ; Plasma volume ; Red cell mass ; Body/venous haematocrit ratio ; Segregation of red cells ; Capillary permeability ; Sepsis ; Leukaemia ; Burns
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Blood volume was estimated using 51chromium labelled red cells and 125iodinated human serum albumin in 5 children with sepsis, in 6 burned children and 7 children with acute lymphoblastic leukaemia. Studies of the equilibration pattern demonstrated that the mixing time of labelled red cells was prolonged to 40 minutes or more in 5 children, indicating the existence of slowly circulating red cells. Mixing of labelled albumin was complete within 10 minutes in 15 patients and within 20 minutes in all the children studied. In a burned patient with severe sepsis, exchange transfusion improved the clinical state and normalized the equilibration pattern of labelled red cells. The mean body/venous haematocrit ratio was 0.893±0.018 (SD) in the children with sepsis, 0.859±0.052 in the burned patients, and 0.916±0.078 in the children with acute lymphoblastic leukaemia, increasing with spleen size in the latter group.
    Type of Medium: Electronic Resource
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