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  • Articles  (3)
  • Bone mineral density  (2)
  • Arachidonic acid  (1)
  • Springer  (3)
  • 1995-1999  (3)
  • 1960-1964
Collection
  • Articles  (3)
Publisher
  • Springer  (3)
Years
  • 1995-1999  (3)
  • 1960-1964
Year
Topic
  • 1
    ISSN: 1572-9699
    Keywords: Arachidonic acid ; isolation ; Mortierella ; soil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Malt extract agar and an incubation temperature of 5 °C were used to selectively isolate representatives of the genus Mortierella from soil. Fungi in a soil sample from mountain grassland able to grow under these conditions, amounted to a total of 2640 colony forming units per gram soil. Circa 94% of the total fungal isolates represented Mortierella subgenus Mortierella. The rest of the colony-forming units consisted of Mucor isolates (6.0%) and higher fungi (1.5%). All the Mortierella isolates produced arachidonic acid.
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  • 2
    ISSN: 1432-198X
    Keywords: Key words: Hypercalciuria ; Na+/K+-ATPase ; Na+/Li+ countertransport ; Thiazides ; Bone mineral density
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Erythrocyte sodium-potassium (Na+/K+) -ATPase and sodium-lithium (Na+/Li+) countertransport activities were measured in 18 children (aged 9.6 years, range 6–16 years) with idiopathic hypercalciuria (IHU) to evaluate cellular Na handling. The effect of chronic thiazide administration on these parameters and on bone mineral density was also evaluated. Patients with IHU had significantly lower erythrocyte Na+/K+-ATPase activity than 23 age-matched healthy controls (mean±SEM 2,156±110 μmol P/l erythrocyte per hour vs. 3,165±175, P〈0.01). Thiazide treatment significantly lowered urinary calcium excretion; this was followed by a slight suppression of intact parathyroid hormone (iPTH). The urinary calcium/creatinine ratio before and during treatment was 0.90±0.07 mmol/mmol versus 0.51±0.06 respectively, P〈0.01. The corresponding iPTH levels were 5.9±0.6 pmol/l and 5.1±0.7, P〈0.05. The Na + /K + -ATPase activity increased significantly (2,769±169 μmol P/l erythrocyte per hour vs. 2,156±110 in the control period, P〈0.01) and the Na + /Li + countertransport decreased (268±28 μmol Li/l erythrocyte per hour vs. 328 + 26 in the control period, P〈0.03). The bone mineral density Z score rose from –1.3±0.26 to –0.8±0.22 (P〈0.03). We conclude that IHU is accompanied by abnormalities of erythrocyte Na + /K + -ATPase and Na + /Li + countertransport which are corrected by chronic hydrochlorothiazide administration. These changes could model alterations in renal tubular transport mechanisms still to be elucidated. Chronic thiazide treatment also has a positive effect on bone mineral density.
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  • 3
    ISSN: 1432-198X
    Keywords: Key words: Hypophosphatemic rickets ; X-linked hypophosphatemia ; Growth hormone ; Bone mineral density
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The impact of recombinant human growth hormone (rhGH) treatment on growth, bone mineral metabolism, and bone mineral density (BMD) was evaluated in six children (3 girls, 3 boys) with familial hypophosphatemic rickets (XLH). Five were prepubertal (aged 6–8.8 years), one 15.3-year-old boy had combined XLH and GH deficiency, but had not been treated with rhGH previously. rhGH was administered daily for 1 year, at a dose of 1 IU/kg per week, combined with 1,25-dihydroxyvitamin D3 and oral phosphate therapy. Z scores for growth velocity and height improved significantly (–2.9 vs. 2.5, P 〈0.01, and –2.2 vs. –1.5, P 〈0.01, respectively). However, the ratio of Z score for height to that of subischial leg length decreased significantly (0.65 vs. 0.43, P 〈0.01), indicating disproportionate growth in favor of the trunk. The height-corrected BMD Z increased slightly (–0.99 vs. –0.94, P 〈0.05). A slight increase in serum phosphate occurred (0.78 vs. 0.88 mmol/l, P 〈0.02). Tubular reabsorption of phosphate/glomerular filtration rate increased from 0.45 mmol/l to 0.55 mmol at 6 months (P 〈0.02), but returned to the initial level at 12 months. These results indicate that children with XLH can benefit from the positive effect of rhGH on growth, however treatment could aggravate the already existing tendency to disproportionate growth. GH production should be evaluated in poorly growing patients with XLH, because it can mask GH deficiency. rhGH can be safely combined with conventional treatment in XLH. Further studies are needed to determine the effect of treatment on final height and maximal BMD.
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