Central Cholinergic Activities
Brain Acetylcholine Level
Springer Online Journal Archives 1860-2000
Abstract The effects of an intracisternal injection of 5,6-Dihydroxytryptamine (5,6-DHT; 75 Μg/rat) on alcohol preference were studied in rats. Results indicated that alcohol consumption was increased significantly from about the 5th to 11th days after treatment. This 5,6-DHT induced alcohol preference was antagonized by 4-(1-naphthylvinyl) pyridine (NVP) (5 mg/kg, i.p. twice daily), an inhibitor of choline acetyltransferase. The level of brain acetylcholine was also increased significantly (P〈0.001) 8 days after 5,6-DHT treatment. It was suggested that the 5,6-DHT induced alcohol preference may be attributed to an increase in central cholinergic activities. The possibility of a modulation of 5-hydroxytryptamine on cholinergic activity was discussed.
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