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  • Brain imaging  (1)
  • Bronchoalveolar lavage fluid (BALF)  (1)
  • Springer  (2)
  • Macmillian Magazines Ltd.
  • Blackwell Publishing Ltd
  • German Medical Science; Düsseldorf, Köln
  • Elsevier
Collection
Publisher
  • Springer  (2)
  • Macmillian Magazines Ltd.
  • Blackwell Publishing Ltd
  • German Medical Science; Düsseldorf, Köln
  • Elsevier
Years
  • 1
    ISSN: 1433-8491
    Keywords: Opercular syndrome ; Pseudobulbar palsy ; Neuropsychological findings ; Brain imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a 66-year-old woman signs and symptoms of bilateral opercular syndrome (Foix-Chavany-Marie-syndrome) developed progressively over a period of more than 10 years. Facio-linguo-velo-pharyngeo-masticatory diplegia with automatic-vol-untary dissociation was accompanied by motor aphasia and oral apraxia leading to a state of almost complete anarthria. Although it initially resembled the anterior biopercular syndrome there are also features indicating involvement of the posterior opercula. Although the aetiology remains obscure without pathological data, a bilateral focal brain atrophy is assumed. This is probably the first case documented by MRI and SPECT.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1750
    Keywords: Pneumoconiosis ; N-acetyl-β-D-glucosaminidase ; Bronchoalveolar lavage fluid (BALF) ; Disease models ; Animal macrophages
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract N-acetyl-beta(β)-D-glucosaminidase is a lysosomal enzyme secreted by alveolar macrophages in response to phagocytosis of particulate material. Alveolar macrophages participate in the degradation and fibrosis of pulmonary tissue that results in pneumoconiosis. Known quantities of four characterized respirable dusts were bronchoscopically placed into the right caudal lung lobe of macaque monkeys. Bronchoalveolar lavage (BAL) samples were collected from dust-exposed right lung and unexposed left lung of the same individuals at 2-week intervals for 12 weeks after dust instillation. The samples were tested for N-acetyl-β-D-glucosaminidase activity to determine if the enzyme levels could serve as an indicator of pulmonary injury induced by generic coal dusts when compared to known fibrogenic and nuisance dusts. Installation of generic quartz, anthracite, or TiO2 dusts produced significant elevations of enzyme activity and increased numbers of macrophages in the dust-exposed lobes. Elevations in enzymatic activity and macrophage numbers were greatest in response to generic quartz dust. These results suggest that quantitative levels of N-acetyl-β-D-glucosaminidase activity may be a useful indicator of acute and chronic lung injury following exposure to fibrogenic and nonfibrogenic dusts.
    Type of Medium: Electronic Resource
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