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  • Analytical Chemistry and Spectroscopy  (3)
  • Breast cancer  (1)
  • 1995-1999  (4)
  • 1920-1924
  • 1
    ISSN: 0935-6304
    Keywords: Epoxytriacylglycerols ; high temperature gas chromatography ; hydroxytriacylglycerols ; ketotriacylglycerols ; lipids ; negative chemical ionization mass spectrometry ; SOP-50 ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Five seed oils consisting of unusual triacylglycerols have been examined by high temperature gas chromatography using glass capillary columns coated with the stationary phase SOP-50 (50%-diphenyl-50%-dimethylpolysiloxane, methoxy-terminated). The investigated hydroxy, epoxy, and ketokonjuene triacylglycerols were first derivatized in order to permit analysis by high temperature gas chromatography. Structural elucidation of the intact triacylglycerols was performed with high temperature gas chromatography/negative chemical ionization-mass spectrometry using NH3 as a reagent gas. Individual derivatized lipid species with a molecular weight up to 1176 g/mol could be identified.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0935-6304
    Keywords: cis-13-Eicosenoic Acid (Paullinic Acid) ; Cyanolipids ; Fatty acids ; GLC-MS ; NMR spectroscopy ; Oxazoline derivatives ; Paullinia elegans Sapindaceae ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The fatty acids of the total lipids, triglycerides, and the cyanolipid of Paullinia elegans (Sapindaceae) have been analyzed as their methyl esters and 4,4-dimethyloxazoline derivatives by gas chromatography-mass spectrometry. It was shown that the gas chromatographic separation of the oxazoline derivatives was sufficient to ensure the correct identification of the monoenic fatty acid positional isomers. Stereochemistry of the double bonds has been confirmed by infrared and 13C-nuclear magnetic resonance (NMR) spectroscopy. cis-13-Eicosenoic Acid (Paullinic acid) (44.4%) and cis-11-octadecenoic acid (cis-vaccenic acid) (19.8%) were found to be the main components beside other monoenoic acid positional isomers. The cyanolipid of P. elegans was identified as 2,4-dihydroxy-3-methylenebutyronitrile derivative by IR, 1H-NMR, 13C-NMR spectroscopy and was quantified by 1H-NMR spectroscopy (71.4%).
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0935-6304
    Keywords: α-Monoacetotriacylglycerides ; Celastraceae ; Fatty acids ; GLC ; GLC-(NCI)MS ; Maytenus seed oils ; OV-225-OH, OH-terminated ; SOP-50, methoxy-terminated ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The seed oils of three Maytenus species have been examined by high temperature GLC using SOP-50 (methoxy-terminated) and OV-225-OH (OH-terminated) glasscapillary columns. The main compounds (71-76%) could be identified as α-mono-acetotriacylglycerols by a combination of high temperature GLC-MS in negative chemical ionization mode with a CH4/N2O mixture as reactant gas and other spectroscopical methods (infrared, 1H- and 13C-nuclear magnetic resonance spectroscopy). The OV-225-OH phase demonstrated better separation properties that the SOP-50 phase for this substance class and up to eight species of α-monoacetotriacylglycerols could be separated. The content of usual triacyclglycerols was below 1%. The results of the analysis of the individual fatty acids as their methyl esters by GC and GC-MS are also presented.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1335
    Keywords: PCNA ; c-erbB-2 ; Histopathology ; Prognosis ; Breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Expression of proliferating cell nuclear antigen (PCNA) and c-erbB-2 oncoprotein has been assessed in 471 women with breast cancer to evaluate their prognostic value as compared to conventional histopathological factors. In univariate analysis, high PCNA expression (≥20%) predicted a significantly worse survival in lymph-node-negative tumors (univariateP=0.031). However, the effect disappeared in multivariate analysis and the histological grade remained the only independent factor for this group. Despite its close correlation to histological grade (P〈0.001), PCNA expression discriminated subsets with different survival within the heterogeneous group of moderately differentiated tumors (univariateP=0.073, multivariateP=0.075). PCNA expression was not found to be a significant prognostic factor in lymph-node-positive tumors, thus it was of limited value for breast cancer patients as a whole. c-erbB-2 protein overexpression was associated with a worse survival (univariateP=0.019, multivariateP=0.057) for the entire group of patients. The effect was mainly attributed to the significance of c-erbB-2 as an independent factor in lymph-node-positive (up to three nodes, multivariateP=0.04; four or more nodes: multivariateP=0.017) and large tumors (〉2 cm: multivariateP=0.002). c-erbB-2 was without significance in lymph-node-negative patients. Though both factors might amplify the prognostic information for distinct patient subsets they do not achieve the strong prognostic value of conventional histopathological features in breast cancer.
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