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  • Budd-Chiari syndrome, liver transplantation  (1)
  • Diagnostik.  (1)
  • Immunohistochemistry  (1)
  • 1
    ISSN: 1432-2277
    Keywords: Liver transplantation, Budd-Chiari syndrome ; Hemoglobinuria, liver transplantation ; Budd-Chiari syndrome, liver transplantation ; PNH, Budd-Chiari syndrome, liver transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 54-year-old male patient with end-stage liver failure from Budd-Chiari syndrome due to paroxysmal nocturnal hemoglobinuria (PNH) underwent liver transplantation (OLT) in 1989. Retransplantation became necessary 1 year later when thrombotic occlusion of the portal vein and common hepatic artery led to graft loss after withdrawal of anticoagulation therapy because of several gastrointestinal bleeding episodes. The patient is now alive 3 years after the first OLT. To the best of our knowledge and according to the literature, this is, to date, the longest that any PNH patient has survived after liver transplantation. Although the course of this patient was complicated in a way similar to that reported for other cases in the literature, patients with PNH should not, in principle, be excluded from liver transplantation. Lifelong anticoagulation with coumarin and the use of steroids together with cyclosporin reduce the risk of recurrent thrombosis and PNH crises.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-0879
    Keywords: Immunohistochemistry ; Bladder carcinoma ; Keratin ; Cytokeratin ; Carcinoembryonic antigen ; Cal ; Prostate-specific antigen ; Prostate acid phosphatase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Keratin was identified with the aid of polyclonal antisera in the cytoplasm in over 90% of the transitional cell carcinomas investigated. The intensity of staining increased with the degree of dedifferentiation. Detection of cytokeratin with monoclonal antibodies was successful in over 80% of samples. All squamous cell carcinomas of the bladder were strongly positive for keratin and cytokeratin. CEA was found in 20% of the G1 and 40% of the G2 and G3 carcinomas of the bladder. Both the prostatic epithelium markers PSA and PAP and the monoclonal antibody Ca1 were negative in all cases.
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  • 3
    ISSN: 1433-0385
    Keywords: Key words: Schwannoma ; Soft tissue tumors ; Surgical therapy ; Diagnosis. ; Schlüsselwörter: Schwannom ; Weichteiltumoren ; chirurgische Therapie ; Diagnostik.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Wir berichten exemplarisch über drei Patienten, die im Zeitraum von Februar 1991 bis Oktober 1994 in unserer Klinik wegen intraabdomineller Schwannome operiert wurden. Im Fall 1 wurde ein benignes Schwannom des Magens durch Billroth-II-Resektion behandelt, Leitsymptom war eine gastrointestinale Blutung. In Fall 2 wurde ein malignes Schwannom des Duodenums mit Lebermetastase durch weite En-bloc-Tumorresektion mit retroperitonealer Lymphadenektomie und anatomischer Rechtsresektion der Leber behandelt. Eine nach 7 Monaten aufgetretene metachrone Lebermetastase wurde durch intraparenchymatöse Lasercoagulation kontrolliert, ein nach 19 Monaten aufgetretenes Lokalrezidiv erforderte eine weitere Tumorresektion. Primäres Leitsymptom war eine palpable Tumormasse. In Fall 3 wurde ein malignes Schwannom der Bauchwand auswärts in Fragmenten reseziert. Trotz postoperativer Radiatio kam es nach 6 Monaten zum Lokalrezidiv mit Leberinfiltration, welches en bloc reseziert wurde. Zu diesem Zeitpunkt bestand bereits eine beginnende Peritonealsarkomatose. Unter postoperativer Chemotherapie kam es zum raschen Tumorprogreß. Der Patient verstarb 18 Monate nach Erstoperation. Anhand der dargestellten Fälle werden Symptomatik, differentialdiagnostische Probleme und operatives Vorgehen bei benignen und malignen Schwannomen des Bauchraums erörtert.
    Notes: Summary. We report three patients who were operated on because of an intraabdominal schwannoma between February 1991 and October 1994 in our department. In the first case, a benign gastric schwannoma was treated by a distal gastric resection (Billroth II); the main symptom was gastric bleeding. In the second case, a malignant duodenal schwannoma with liver metastasis was treated by wide en-bloc resection of the tumor including retroperitoneal lymphadenectomy and an anatomical resection of the right lobe of the liver. A metachronous metastasis of the liver, appearing 7 months postoperatively, was treated by intraparenchymatous laser coagulation; a local recurrence, appearing 19 months postoperatively, led to another tumor resection. The main symptom was a palpable intraabdominal mass in this case. In the third case, a malignant schwannoma of the abdominal wall was resected in fragments in another clinic. Six months later a local recurrence with infiltration of the liver appeared in spite of postoperative radiation and was resected en bloc. Early peritoneal sarcomatosis was apparent at that time. Postoperative chemotherapy did not prevent quick progression of the tumor. The patient died 18 months after the first operation. The clinical presentation, differential diagnosis and operative strategy for benign and malignant intraabdominal schwannomas are discussed.
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