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  • 1
    Keywords: DIAGNOSIS ; CANCER ; ARRAYS ; ARRAY ; development ; pancreas ; MASSES ; EXOCRINE PANCREAS ; DIFFERENTIAL-DIAGNOSIS ; MASS ; pancreatic
    Type of Publication: Book chapter
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizin - Bibliothek - Information; VOL: 16; DOC01 /20160923/
    Publication Date: 2016-09-23
    Description: The focus of the current issue 1-2/2016 of GMS Medizin - Bibliothek - Information is on the future of ZB MED. The authors of the focus articles are Klaus-Rainer Brintzinger (ZB MED: What value comes to library infrastructure within science?), Iris Reimann (The importance of ZB MED for the German MLA / AGMB) and Bruno Bauer (No future for ZB MED! Or maybe: a future for ZB MED?).Furthermore this issue features articles from Maurizio Grilli (A practical method for systematic searching of literature in medical libraries), Oliver Obst (Use of tablets for the study of medicine. Part 2: The project easyphysikum), Jana Pössel (Usability test of the new ZB MED search portal LIVIVO), Holger Laube, Alena Ittner, Sandra Pfob and Alexander Schröder (Fast as lightning to literature: ordering of literature in flow), Iris Reimann (German MLA (AGMB) News) and Bruno Bauer (The Medical Librarian's Bibliography 2015).
    Description: Die aktuelle Ausgabe 1-2/2016 von GMS Medizin - Bibliothek - Information ist dem Thema "Zukunft von ZB MED" gewidmet. Verfasst wurden die Beiträge der Schwerpunktausgabe von Klaus-Rainer Brintzinger (ZB MED: Welchen Stellenwert hat die bibliothekarische Infrastruktur für die Wissenschaft?), Iris Reimann (Die Bedeutung von ZB MED für die AGMB) und Bruno Bauer (ZB MED ohne Zukunft! Oder doch: Zukunft für ZB MED?).Weiters bringt die aktuelle Ausgabe von GMS Medizin - Bibliothek - Information Beiträge von Maurizio Grilli (Eine praktische Methode zur systematischen Literaturrecherche an Medizinbibliotheken), Oliver Obst (Die Integration von Tablet-Computern in das Medizinstudium. Teil 2: Das easyphysikum-Projekt), Jana Pössel (Usability-Untersuchung des neuen ZB MED-Suchportals LIVIVO), Holger Laube, Alena Ittner, Sandra Pfob und Alexander Schröder (Blitzschnell zur Literatur: Literaturbestellung im Fluss), Iris Reimann (Aus der AGMB) sowie von Bruno Bauer (Medizinbibliothekarische Bibliografie 2015).
    Keywords: German National Library of Medicine ; ZB MED - Leibniz Information Centre for Life Sciences ; evaluation ; future ; editorial ; Deutsche Zentralbibliothek für Medizin ; ZB MED - Leibniz-Informationszentrum Lebenswissenschaften ; Evaluierung ; Zukunft ; Editorial ; ddc: 610
    Language: German
    Type: article
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizin - Bibliothek - Information; VOL: 14; DOC01 /20140828/
    Publication Date: 2014-08-29
    Description: The focus of the current issue 1-2/2014 of GMS Medizin - Bibliothek - Information is on "Teaching Library: information literacy instruction at medical libraries". The authors in this issue are Marina Betker & Annette Kustos (Literature research training in health sciences in a new academic library - straight through and strategic planning: the concept of the "hsg Bochum"), Simone Waldboth (Integration of e-learning in the lecture "Information Literacy" at the Provincial College for Health-Care Professions "Claudiana"), Michaele Adam & Jens Mittelbach (Shaping the Future at the SLUB Dresden with Information Literacy in the Research Cycle), Gregor Steinrisser (Sucessfully failing - Fiction and Friction of a teaching library in university and clinical daily routine), Melanie Kintzel & Norbert Sunderbrink (Information literacy classes at the Medical Library of the University Medical Center Hamburg-Eppendorf), Markus Schmiel (The teaching and learning concept of the Library of the Hannover Medical School), Jutta Matrisciano & Martina Semmler-Schmetz (Teaching Library - Realization of a concept with many facets at the Library for the Medical Faculty of Mannheim), Karin Cepicka ("Teaching Library" at the Library oft the Medical University Vienna), Helmut Dollfuß (Library user education for the new curriculum at the Medical University Vienna), Manuela Rohrmoser & Irene Schachl (The cooperations of teaching librarians at Vienna University Library) und Claudia Hausberger & David Frank (Curriculum reform - a work report from the Library of the University of Veterinary Medicine Vienna).
    Description: Die aktuelle Ausgabe 1-2/2014 von GMS Medizin - Bibliothek - Information ist dem Thema "Teaching Library: Vermittlung von Informationskompetenz an medizinischen Bibliotheken" gewidmet. Verfasst wurden die Beiträge der Schwerpunktausgabe von Marina Betker & Annette Kustos (Über Angebote zur gesundheitswissenschaftlichen Informationskompetenz in einer neuen Bibliothek - Querfliegen und strategisch Planen: Das Konzept der HSG Bochum), Simone Waldboth (Integration von E-Learning in die Vermittlung von Informationskompetenz an der Claudiana), Michaele Adam & Jens Mittelbach (Mit Informationskompetenz im Forschungsprozess die Zukunft an der SLUB Dresden gestalten), Gregor Steinrisser (Erfolgreiches Scheitern - Fiktion und Friktion einer Teaching Library zwischen Wissenschaft und klinischem Alltag), Melanie Kintzel & Norbert Sunderbrink (Die Vermittlung von Informationskompetenz in der Ärztlichen Zentralbibliothek des Universitätsklinikums Hamburg-Eppendorf), Markus Schmiel (Das Lehr und Lernkonzept der Bibliothek der Medizinischen Hochschule Hannover), Jutta Matrisciano & Martina Semmler-Schmetz (Teaching Library - Umsetzung eines Konzeptes in vielen Facetten an der Bibliothek der Medizinischen Fakultät Mannheim), Karin Cepicka (Teaching Library an der Universitätsbibliothek der Medizinischen Universität Wien), Helmut Dollfuß (Die Lehrveranstaltungen der Bibliothek im neuen Curriculum der Medizinischen Universität Wien), Manuela Rohrmoser & Irene Schachl (Kooperationen der Teaching Library an der Universitätsbibliothek Wien) und Claudia Hausberger & David Frank (Curriculumsreform - ein Arbeitsbericht aus der Universitätsbibliothek der Veterinärmedizinischen Universität Wien).
    Keywords: Teaching Library ; information literacy ; medical library ; learning center ; teaching concept ; training course ; editorial ; Teaching Library ; Informationskompetenz ; Medizinbibliothek ; Lernort ; Lernkonzept ; Schulung ; Editorial ; ddc: 610
    Language: German
    Type: article
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizin - Bibliothek - Information; VOL: 9; DOC01 /20090616/
    Publication Date: 2009-06-17
    Description: The recent issue 1/2009 of GMS Medizin - Bibliothek - Information has a focus on "The green road to open Access: institutional and subject repositories". Self-archiving and storing scholarly publications on a print server were also central topics in many presentations at the 9th International Bielefeld Conference in February 2009. The authors in this issue are Birgit Schmidt and Karin Ilg-Hartecke (Open Access in Deutschland - erweiterte Perspektiven für die Wissenschaft), Christoph Bruch and Anja Lengenfelder (Unterstützung des Grünen Weges zu Open Access an der Max-Planck-Gesellschaft), Ulrich Herb and Matthias Müller (Nuancen in Grün: Betrieb eines institutionellen und disziplinären Repositoriums - Erfahrungen und Entwicklungen an der Saarländischen Universitäts- und Landesbibliothek), Timo Borst and Jan B. Weiland (EconStor: ein fachliches Repositorium für die Wirtschaftswissenschaften), Antonella de Robbio and Michael Katzmayr (The management of an international open access repository: the case of E-LIS) and Christian Gumpenberger (The EPrints story: Southampton as the cradle of institutional self-archiving). Furthermore this focus issue features an interview of a representative of a research funding organisation (Repositorien: Der grüne Weg zu Open Access Publishing aus der Perspektive einer Forschungsförderungsorganisation. 10 Fragen von Bruno Bauer an Falk Reckling, Mitarbeiter des FWF Der Wissenschaftsfonds) and an interview of a publisher (Repositorien: Der grüne Weg zu Open Access Publishing aus der Perspektive der International Association of Scientific, Technical & Medical Publishers (STM): 10 Fragen von Bruno Bauer an Barbara Kalumenos, Director of Public Affairs bei STM).
    Description: Schwerpunktthema der aktuellen Ausgabe 1/2009 von GMS 〈TextGroup〉 Medizin - 〈/TextGroup〉 Bibliothek - Information ist "Der grüne Weg zu Open Access: institutionelle und fachliche Repositorien". Die Selbstarchivierung, das Einbringen wissenschaftlicher Fachpublikation in einen Dokumentenserver, war auch ein zentrales Thema vieler Beiträge der 9. Internationalen Bielefeld Konferenz im Februar 2009. Die Beiträge der aktuellen Schwerpunktausgabe wurden verfasst von Birgit Schmidt und Karin Ilg-Hartecke (Open Access in Deutschland - erweiterte Perspektiven für die Wissenschaft), Christoph Bruch und Anja Lengenfelder (Unterstützung des Grünen Weges zu Open Access an der Max-Planck-Gesellschaft), Ulrich Herb und Matthias Müller (Nuancen in Grün: Betrieb eines institutionellen und disziplinären Repositoriums - Erfahrungen und Entwicklungen an der Saarländischen Universitäts- und Landesbibliothek), Timo Borst und Jan B. Weiland (EconStor: ein fachliches Repositorium für die Wirtschaftswissenschaften), Antonella de Robbio und Michael Katzmayr (The management of an international open access repository: the case of E-LIS), Christian Gumpenberger (The EPrints story: Southampton as the cradle of institutional self-archiving). Ergänzt wird die Schwerpunktausgabe durch Interviews, geführt mit jeweils einem Vertreter der Forschungsförderungsorganisationen (Repositorien: Der grüne Weg zu Open Access Publishing aus der Perspektive einer Forschungsförderungsorganisation. 10 Fragen von Bruno Bauer an Falk Reckling, Mitarbeiter des FWF Der Wissenschaftsfonds) bzw. der Verlage (Repositorien: Der grüne Weg zu Open Access Publishing aus der Perspektive der International Association of Scientific, Technical & Medical Publishers (STM): 10 Fragen von Bruno Bauer an Barbara Kalumenos, Director of Public Affairs bei STM).
    Keywords: open access publishing ; grean road to open access ; self-archiving ; institutional respository ; subject repository ; 9th Bielefeld Conference 2009 ; editorial ; Open Access Publishing ; grüner Weg zu Open Access ; Selbstarchivierung ; institutionelles Repositorium ; fachliches Repositorium ; 9. Bielefeld Konferenz 2009 ; Editorial ; ddc: 610
    Language: German
    Type: article
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  • 5
    Keywords: CANCER ; CELLS ; EXPRESSION ; tumor ; TUMOR-CELLS ; carcinoma ; CELL ; Germany ; neoplasms ; DIAGNOSIS ; NEW-YORK ; microarray ; transcription ; TISSUE ; DNA ; MICROARRAY DATA ; MUTATIONS ; Jun ; PHENOTYPE ; vimentin ; HEAD ; adenocarcinoma ; pathology ; BEHAVIOR ; MICROARRAY ANALYSIS ; expression profiling ; TUMOR CELLS ; DIFFERENTIAL-DIAGNOSIS ; CELL CARCINOMA ; OF-THE-LITERATURE ; pancreas ; review ; DUCTAL ADENOCARCINOMA ; AUTOPSY ; analysis ; pancreatic ; TUMOR-CELL ; GENOTYPE ; DNA-MICROARRAY ; USA ; pancreatic ductal adenocarcinoma ; MYOEPITHELIAL CARCINOMA ; pancreatic neoplasm ; PSEUDOPAPILLARY TUMORS
    Abstract: Pancreatic neoplasms have been reliably classified on the basis of their histopathology and immunophenotype. In this study, we report on a pancreatic tumor whose phenotype and genotype could not be assigned to any known tumor entity. The tumor was observed in the pancreatic head of a 54-year-old woman. It was found to be a solid infiltrating carcinoma with abundant clear cells. Apart from cytokeratin, the tumor cells expressed vimentin, S100, and MUC-1. DNA microarray analysis revealed a transcription profile clearly differing from that of normal pancreatic tissue and pancreatic ductal adenocarcinoma. Despite metastatic behavior, the tumor displayed a more favorable course than conventional pancreatic ductal adenocarcinoma. We suggest that this tumor be called solid type clear cell carcinoma of the pancreas
    Type of Publication: Journal article published
    PubMed ID: 17453235
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  • 6
    Keywords: CANCER ; tumor ; CELL ; Germany ; human ; SYSTEM ; SYSTEMS ; DISEASE ; liver ; PROTEIN ; PROTEINS ; SAMPLE ; SAMPLES ; MOLECULES ; TISSUE ; TISSUES ; BIOLOGY ; MOLECULE ; IDENTIFICATION ; MEMBRANE ; INSTABILITY ; ELECTROPHORESIS ; pancreatic cancer ; SECTIONS ; molecular biology ; pancreas ; PANCREATIC-CANCER ; EXTRACTION ; SEPARATION ; USA ; protein fractionation ; CELL-CELL ; EFFECTOR MOLECULE ; ISLETS ; protein extraction
    Abstract: Proteins are the major class of effector molecules in cellular systems. For the identification of functional differences between normal and diseased tissues, a reliable analysis of their protein content is essential. Reproducible isolation and fractionation of intact proteins are important in this respect, but their complexity in structure and concentration, their close interaction, and their instability represent major challenges. For protein isolation in tissues, the breakdown of cell-cell and cell-matrix connections within a tissue without affecting protein quality is a critical factor. We compared different processes for a compartmental protein preparation from pancreatic tissue, one of the most challenging tissues for protein isolation because of its high protease content. Success of the different procedures varied greatly. Based on a scheme of tissue-slicing and subsequent cell isolation, we established a reliable workflow for the fractional extraction of cytosolic proteins, membrane and organelle proteins, nuclear proteins, and cytoskeletal filaments. The tissue slices also allow for a representative confirmation of individual samples' cellular status by histochemical processes, and a proper separation or mixing of cellular material from across a tumor if required
    Type of Publication: Journal article published
    PubMed ID: 19450236
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  • 7
    Keywords: CANCER ; COMBINATION ; Germany ; LUNG ; SYSTEM ; SYSTEMS ; liver ; GENOME ; microarray ; PROTEIN ; PROTEINS ; TISSUE ; HEART ; QUALITY ; RAT ; antibody ; DESIGN ; MEMBRANE ; PROTEOMICS ; PANCREATIC-CANCER ; 2-DIMENSIONAL ELECTROPHORESIS ; antibody microarray ; FUNCTIONALITY ; MEMBRANE-PROTEINS ; protein extraction ; compartmentalized protein ; DETERGENTS
    Abstract: The process of extracting comprehensive proteome representations is a crucial step for many proteomic studies. While antibody microarrays are an evolving and promising methodology in proteomics, the issue of protein extraction from tissues for this kind of analysis has never been addressed. Here, we describe a single-step extraction buffer for the isolation of proteins from mammalian tissues under native conditions in an effective and reproducible manner. Protein was extracted from cell lines BxPC-3 and SU.86.86, rat organs (pancreas, liver, heart and lung) and human pancreatic cancer tissues using several buffer systems that contained individual nonionic or zwitterionic detergents in comparison to commercial extraction buffers. Also, detergent combinations were used that included at least one polymeric phenylethylene glycol, a long-chain amidosulfobetaine, cholate and a zwitterionic detergent. Extracts were analyzed for protein quantity and quality. The detergent cocktails exhibited superior extraction capacity. Additionally, they demonstrated a substantially higher recovery of membrane and compartmental proteins as well as much better preservation of protein functionality. Also, they did not interfere with subsequent analysis steps such as labeling. In Western blot and antibody microarray assays, they outperformed the other buffer systems, indicating that they should also be useful for other types of proteomic studies
    Type of Publication: Journal article published
    PubMed ID: 20047340
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  • 8
    Keywords: CANCER ; EXPRESSION ; Germany ; RISK ; GENE ; GENE-EXPRESSION ; GENES ; TUMORS ; PROGRESSION ; PATTERNS ; gene expression ; genetics ; DELETIONS ; REGION ; PHENOTYPE ; MICROARRAY ANALYSIS ; METHYLATION ; neuroblastoma ; ONCOLOGY ; PATTERN ; CANDIDATE GENES ; DNA COPY NUMBER ; SUBTYPES ; EXPRESSION PROFILES ; HIGH-RESOLUTION ANALYSIS ; SUBGROUPS ; outcome ; CELL BIOLOGY ; Genetic ; 4S NEUROBLASTOMA ; integrative genomics ; loss of 11q
    Abstract: Imbalances in chromosome 11q occur in approximately 30% of primary neuroblastoma and are associated with poor outcome. It has been suggested that 11q loss constitutes a distinct clinico-genetic neuroblastoma subgroup by affecting expression levels of corresponding genes. This study analysed the relationship of 11q loss, clinical phenotype and global transcriptomic profiles in four clinico-genetic subgroups (11q alteration/favourable outcome, n = 7; 11q alteration/unfavourable outcome, n 14; no 11q alteration/favourable outcome, n 81; no 11q alteration/unfavourable outcome, n 8; tumours with MYCN amplification and/or 1p loss were excluded). Unsupervised and supervised comparisons of gene expression profiles consistently showed significantly different mRNA patterns between favourable and unfavourable neuroblastomas, both in the subgroups with and without 11q loss. In contrast, favourable tumours with and without 11q loss showed highly similar transcriptomic profiles. Disproportionate downregulation of 11q genes was observed only in unfavourable tumours with 11q loss. The diverging molecular profiles were neither caused by considerable differences in the size of the deleted regions nor by differential methylation patterns of 11q genes. Together, this study shows that neuroblastoma with 11q loss comprises two biological subgroups that differ both in their clinical phenotype and gene expression patterns, indicating that 11q loss is not a primary determinant of neuroblastoma tumour behaviour. Oncogene (2010) 29, 865-875; doi:10.1038/onc.2009.390; published online 9 November 2009
    Type of Publication: Journal article published
    PubMed ID: 19901960
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  • 9
    Keywords: CANCER ; EXPRESSION ; CELL ; Germany ; GENOME ; microarray ; PROTEIN ; PROTEINS ; PATIENT ; COMPLEX ; COMPLEXES ; QUALITY ; BIOLOGY ; antibodies ; antibody ; ASSAY ; microarrays ; DESIGN ; ARRAYS ; REPRODUCIBILITY ; CANCER-PATIENTS ; CANCER PATIENTS ; pancreatic cancer ; PROTEOMICS ; PROTEOMIC ANALYSIS ; SERUM ; FEATURES ; PANCREATIC-CANCER ; antibody microarray ; HEALTHY-SUBJECTS ; methods ; HUMAN PLASMA ; DEPLETION ; QUANTITATIVE PROTEOMICS ; proteomic ; ABUNDANCE PROTEINS ; BIOMARKER DISCOVERY
    Abstract: Antibody microarrays have the potential to enable comprehensive proteomic analysis of small amounts of sample material. Here, protocols are presented for the production, quality assessment, and reproducible application of antibody microarrays in a two-color mode with an array of 1,800 features, representing 810 antibodies that were directed at 741 cancer-related proteins. In addition to measures of array quality, we implemented indicators for the accuracy and significance of dual-color detection. Dual-color measurements outperform a single-color approach concerning assay reproducibility and discriminative power. In the analysis of serum samples, depletion of high-abundance proteins did not improve technical assay quality. On the contrary, depletion introduced a strong bias in protein representation. In an initial study, we demonstrated the applicability of the protocols to proteins derived from urine samples. We identified differences between urine samples from pancreatic cancer patients and healthy subjects and between sexes. This study demonstrates that biomedically relevant data can be produced. As demonstrated by the thorough quality analysis, the dual-color antibody array approach proved to be competitive with other proteomic techniques and comparable in performance to transcriptional microarray analyses.
    Type of Publication: Journal article published
    PubMed ID: 20164060
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  • 10
    Keywords: RECEPTOR ; CANCER ; COHORT ; DISEASE ; MORTALITY ; POPULATION ; RISK ; GENES ; ASSOCIATION ; POLYMORPHISMS ; single nucleotide polymorphism ; pancreatic cancer ; SINGLE NUCLEOTIDE POLYMORPHISMS ; susceptibility loci ; Adiponectin ; GENOME-WIDE ASSOCIATION
    Abstract: Pancreatic cancer has one of the worst mortality rates of all cancers. Little is known about its etiology, particularly regarding inherited risk. The PanScan project, a genome-wide association study, identified several common polymorphisms affecting pancreatic cancer susceptibility. Single nucleotide polymorphisms (SNPs) in ABO, sonic hedgehog (SHH), telomerase reverse transcriptase (TERT), nuclear receptor subfamily 5, group A, member 2 (NR5A2) were found to be associated with pancreatic cancer risk. Moreover the scan identified loci on chromosomes 13q22.1 and 15q14, to which no known genes or other functional elements are mapped. We sought to replicate these observations in two additional, independent populations (from Germany and the UK), and also evaluate the possible impact of these SNPs on patient survival. We genotyped 15 SNPs in 690 cases of pancreatic ductal adenocarcinoma (PDAC) and in 1277 healthy controls. We replicated several associations between SNPs and PDAC risk. Furthermore we found that SNP rs8028529 was weakly associated with a better overall survival (OS) in both populations. We have also found that NR5A2 rs12029406_T allele was associated with a shorter survival in the German population. In conclusion, we found that rs8028529 could be, if these results are replicated, a promising marker for both risk and prognosis for this lethal disease.
    Type of Publication: Journal article published
    PubMed ID: 22125638
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