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  • 1
    Keywords: CANCER ; CELLS ; tumor ; Germany ; IN-VIVO ; MODEL ; DISEASE ; MICE ; RESPONSES ; DONOR ; GRAFT ; ANTIGEN ; T-CELL ; T-CELLS ; FREQUENCY ; bone marrow ; BONE-MARROW ; IMMUNE-RESPONSES ; MEMORY ; NOD/Scid mice ; NUMBER ; leukemia ; LYMPHOCYTES ; graft-versus-leukemia ; IMMUNE-RESPONSE ; NAIVE ; HOST-DISEASE ; METASTATIC TUMOR ; SINGLE ; RE ; LIFE ; PROTECTIVE IMMUNITY ; memory T cells ; REMISSION ; ADOPTIVE TRANSFER ; MINOR HISTOCOMPATIBILITY ANTIGENS ; bone marrow cells ; immune memory T cells
    Abstract: The bone marrow has been shown to represent a unique microenvironment where T cell immune responses against tumor associated antigens can be initiated and tumor-immune memory T cells are enriched. In the present Study the graft versus leukemia (GvL) reactivity of bone marrow derived tumor-immune memory T cells was analyzed in an allogeneic minor histocompatibility different murine GvL tumor model with late stage disease. A single adoptive cell transfer of B10.D2 donor immune bone marrow cells (iBM) into sub-lethally irradiated late stage ESb-MP tumor-bearing DBA/2 mice led to a complete tumor remission and to significant life prolongation. Even though the frequency of bone marrow resident T cells is only around 2%, the GvL reactivity of iBM was superior to immune cells from the spleen (iSPL) or to those from the peritoneal cavity (iPEC) of the same immunized donors. iPEC exerted mostly unwanted graft versus host (GvH) reactivity, while iSPL exerted GvL and GvH reactivity. Bone marrow cells from naive donor mice or T cell depleted iBM cells were completely devoid of GvL reactivity. The low number of tumor-immune memory T cells thus conferred the GvL reactivity of iBM cells
    Type of Publication: Journal article published
    PubMed ID: 16142333
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Phytochemistry 25 (1986), S. 2509-2513 
    ISSN: 0031-9422
    Keywords: Eustoma grandiflorum ; Gentianaceae ; acylated anthocyanins ; acylated flavonols. ; flavonols ; prairie gentian
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Plant cell, tissue and organ culture 8 (1987), S. 249-253 
    ISSN: 1573-5044
    Keywords: tissue culture ; micropropagation ; Lisianthus ; Eustoma grandiflorum ; Texas Bluebells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Explants of shoot tips, internodal stem sections, and leaf segments of Lisianthus, Eustoma grandiflorum (Griseb.) Schinners, ‘Dwarf Purple’ were cultured in vitro on modified Murashige and Skoog (MS) media. Explants of shoot tips and internodal stem sections developed into multiple shoots, whereas, leaf segments turned chlorotic on a medium supplemented with 3 mgl-1 benzyladenine (BA) and 0.2 mgl-1 naphthalene acetic acid (NAA). Shoot proliferation was obtained on shoot tips and leaf segments with 3 mgl-1 BA, but internodal stem sections became necrotic and died on this medium. Rooting was induced in cultures with multiple shoots by subculturing explants on a half-strength MS medium supplemented with 2 mgl-1 indole-3-acetic acid (IAA). Rooted plantlets were successfully transferred to soil.
    Type of Medium: Electronic Resource
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