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  • CANCER  (3)
  • 1
    Keywords: CANCER ; tumor ; carcinoma ; Germany ; LUNG ; PERFUSION ; THERAPY ; CT ; DENSITY ; LUNG-CANCER ; NEW-YORK ; TUMORS ; PATIENT ; CONTRAST ; INJECTION ; treatment ; DIFFERENCE ; REGION ; REGIONS ; LOCALIZATION ; PARAMETERS ; tomography ; CARCINOMAS ; COMPUTED-TOMOGRAPHY ; PET ; lung neoplasms ; PULMONARY ; DYNAMIC CT ; X-ray computed
    Abstract: Advanced bronchial carcinomas by means of perfusion and peak enhancement using dynamic contrast-enhanced multislice CT are characterized. Twenty-four patients with advanced bronchial carcinoma were examined. During breathhold, after injection of a contrast-medium (CM), 25 scans were performed (I scan/s) at a fixed table position. Density-time curves were evaluated from regions of interest of the whole tumor and high- and low-enhancing tumor areas. Perfusion and peak enhancement were calculated using the maximum-slope method of Miles and compared with size, localization (central or peripheral) and histology. Perfusion of large tumors (〉50 cm(3)) averaged over both the whole tumor (P=0.001) and the highest enhancing area (P=0.003) was significantly lower than that of smaller ones. Independent of size, central carcinomas had a significantly (P=0.04) lower perfusion (mean 27.9 ml/min/100 g) than peripheral ones (mean 66.5 ml/min/100 9). In contrast, peak enhancement of central and peripheral carcinomas was not significantly different. Between non-small-cell lung cancers and small-cell lung cancers, no significant differences were observed in both parameters. In seven tumors, density increase after CM administration started earlier than in the aorta, indicating considerable blood supply from pulmonary vessels. Tumor perfusion was dependent on tumor size and localization, but not on histology. Furthermore, perfusion CT disclosed blood supply from both pulmonary and/or bronchial vessels in some tumors
    Type of Publication: Journal article published
    PubMed ID: 15029450
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  • 2
    Keywords: brain ; RECEPTOR ; CANCER ; EXPRESSION ; BLOOD ; Germany ; LUNG ; MODEL ; imaging ; lung cancer ; LUNG-CANCER ; POPULATION ; GENE ; GENE-EXPRESSION ; TISSUE ; PATIENT ; CONTRAST ; gene expression ; metastases ; PARAMETERS ; SCINTIGRAPHY ; PET ; SOMATOSTATIN ; QUANTITATIVE ASSESSMENT ; RE ; SOMATOSTATIN ANALOG ; GA-68-DOTATOC ; LOSSES ; uptake ; FDG ; viability ; DOTATOC ; EMISSION-TOMOGRAPHY ; F-18-FDG PET ; kinetic modelling ; kinetic parameters ; non-small cell lung tumours ; TC-99M DEPREOTIDE
    Abstract: Purpose: Dynamic PET studies with Ga-68-DOTATOC were performed in patients with non-small cell lung cancer (NSCLC) to assess the somatostatin receptor 2 (SSTR2) expression. Furthermore, dynamic F-18-fluorodeoxyglucose (FDG) studies were performed in the same patients to compare the SSTR2 expression with the tumour viability. Methods: The study population comprised nine patients, examined with both tracers on two different days within 1 week. Standardised uptake values (SUVs) were calculated and a two-tissue compartment model was applied to the data. Furthermore, a non-compartment model based on the fractal dimension (FD) was applied to the data. Results: The DOTATOC uptake was generally lower than the FDG uptake. Moderately enhanced DOTATOC uptake was noted in seven of the nine tumours. All kinetic parameters exceptk (4) were lower for DOTATOC than for FDG. The mean SUV was 2.018 for DOTATOC, in comparison to 5.683 for FDG. In particular,k (3) was highly variable for DOTATOC and showed an overlap with the normal lung tissue. The fractional blood volumeV (B) was relatively low for both tracers, not exceeding 0.3. The highest significant logarithmic correlation was found for the FD of the two tracers (r=0.764,p=0.017). The logarithmic correlation for SUVs was also significant (r=0.646,p=0.060), as was that forV (B) (r=0.629,p=0.069). In contrast, none of the eight metastases which were positive on FDG PET showed any DOTATOC uptake. Conclusion: The results demonstrated moderate Ga-68-DOTATOC uptake in primary NSCLC but did not provide any evidence for SSTR2 expression in metastases. This may be caused by loss of the gene expression in metastases as compared with the primary tumours
    Type of Publication: Journal article published
    PubMed ID: 16570185
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  • 3
    Keywords: CANCER ; radiotherapy ; carcinoma ; Germany ; LUNG ; imaging ; thorax ; RESOLUTION ; PATIENT ; tumour ; MRI ; CYCLE ; SEQUENCE ; SEQUENCES ; LESIONS ; MOBILITY ; MOTION ; QUANTITATIVE-ANALYSIS ; dynamic MRI ; STAGE-I ; TRUEFISP ; GRADIENT-ECHO ; breathing cycle ; DIAPHRAGM ; HEALTHY-SUBJECTS ; lung motion ; parallel imaging ; SENSE ; SMASH ; TEMPORAL RESOLUTION ; volumetry
    Abstract: The purpose of this study was to describe the use of parallel imaging technique (PAT) using dynamic MRI in lung and tumour-mobility during the breathing cycle. 20 patients with stage I non-small cell lung carcinoma were investigated using two dynamic gradient echo sequences with PAT (TrueFISP (fast imaging with steady precession), and fast low angle shot (FLASH). Craniocaudal distance from the apex to the diaphragm of the thorax and tumour mobility during the breathing cycle were measured. Signal-to-noise ratio (SNR) of the tumour was determined. In spite of the different temporal resolutions both trueFISP and FLASH sequence proved to be adequate to continuously measure lung motion and tumour mobility. SNR of the tumour was significantly higher using the trueFISP sequence than FLASH sequence (20.7 +/- 3.6 vs 5.8 +/- 2.3, p 〈 0.01). Mobility of the tumour bearing hemithorax was significantly lower compared with the non-tumour bearing hemithorax (p 〈 0.05). Dynamic MRI using PAT allows for continuous quantitative documentation of tumour mobility and lung motion. Because of the higher SNR, trueFISP sequence provides a better delineation of intrapulmonary lesions with a sufficient temporal resolution
    Type of Publication: Journal article published
    PubMed ID: 16110107
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