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  • 1
    Keywords: DIAGNOSIS ; CANCER ; ARRAYS ; ARRAY ; development ; pancreas ; MASSES ; EXOCRINE PANCREAS ; DIFFERENTIAL-DIAGNOSIS ; MASS ; pancreatic
    Type of Publication: Book chapter
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizin - Bibliothek - Information; VOL: 16; DOC01 /20160923/
    Publication Date: 2016-09-23
    Description: The focus of the current issue 1-2/2016 of GMS Medizin - Bibliothek - Information is on the future of ZB MED. The authors of the focus articles are Klaus-Rainer Brintzinger (ZB MED: What value comes to library infrastructure within science?), Iris Reimann (The importance of ZB MED for the German MLA / AGMB) and Bruno Bauer (No future for ZB MED! Or maybe: a future for ZB MED?).Furthermore this issue features articles from Maurizio Grilli (A practical method for systematic searching of literature in medical libraries), Oliver Obst (Use of tablets for the study of medicine. Part 2: The project easyphysikum), Jana Pössel (Usability test of the new ZB MED search portal LIVIVO), Holger Laube, Alena Ittner, Sandra Pfob and Alexander Schröder (Fast as lightning to literature: ordering of literature in flow), Iris Reimann (German MLA (AGMB) News) and Bruno Bauer (The Medical Librarian's Bibliography 2015).
    Description: Die aktuelle Ausgabe 1-2/2016 von GMS Medizin - Bibliothek - Information ist dem Thema "Zukunft von ZB MED" gewidmet. Verfasst wurden die Beiträge der Schwerpunktausgabe von Klaus-Rainer Brintzinger (ZB MED: Welchen Stellenwert hat die bibliothekarische Infrastruktur für die Wissenschaft?), Iris Reimann (Die Bedeutung von ZB MED für die AGMB) und Bruno Bauer (ZB MED ohne Zukunft! Oder doch: Zukunft für ZB MED?).Weiters bringt die aktuelle Ausgabe von GMS Medizin - Bibliothek - Information Beiträge von Maurizio Grilli (Eine praktische Methode zur systematischen Literaturrecherche an Medizinbibliotheken), Oliver Obst (Die Integration von Tablet-Computern in das Medizinstudium. Teil 2: Das easyphysikum-Projekt), Jana Pössel (Usability-Untersuchung des neuen ZB MED-Suchportals LIVIVO), Holger Laube, Alena Ittner, Sandra Pfob und Alexander Schröder (Blitzschnell zur Literatur: Literaturbestellung im Fluss), Iris Reimann (Aus der AGMB) sowie von Bruno Bauer (Medizinbibliothekarische Bibliografie 2015).
    Keywords: German National Library of Medicine ; ZB MED - Leibniz Information Centre for Life Sciences ; evaluation ; future ; editorial ; Deutsche Zentralbibliothek für Medizin ; ZB MED - Leibniz-Informationszentrum Lebenswissenschaften ; Evaluierung ; Zukunft ; Editorial ; ddc: 610
    Language: German
    Type: article
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizin - Bibliothek - Information; VOL: 14; DOC01 /20140828/
    Publication Date: 2014-08-29
    Description: The focus of the current issue 1-2/2014 of GMS Medizin - Bibliothek - Information is on "Teaching Library: information literacy instruction at medical libraries". The authors in this issue are Marina Betker & Annette Kustos (Literature research training in health sciences in a new academic library - straight through and strategic planning: the concept of the "hsg Bochum"), Simone Waldboth (Integration of e-learning in the lecture "Information Literacy" at the Provincial College for Health-Care Professions "Claudiana"), Michaele Adam & Jens Mittelbach (Shaping the Future at the SLUB Dresden with Information Literacy in the Research Cycle), Gregor Steinrisser (Sucessfully failing - Fiction and Friction of a teaching library in university and clinical daily routine), Melanie Kintzel & Norbert Sunderbrink (Information literacy classes at the Medical Library of the University Medical Center Hamburg-Eppendorf), Markus Schmiel (The teaching and learning concept of the Library of the Hannover Medical School), Jutta Matrisciano & Martina Semmler-Schmetz (Teaching Library - Realization of a concept with many facets at the Library for the Medical Faculty of Mannheim), Karin Cepicka ("Teaching Library" at the Library oft the Medical University Vienna), Helmut Dollfuß (Library user education for the new curriculum at the Medical University Vienna), Manuela Rohrmoser & Irene Schachl (The cooperations of teaching librarians at Vienna University Library) und Claudia Hausberger & David Frank (Curriculum reform - a work report from the Library of the University of Veterinary Medicine Vienna).
    Description: Die aktuelle Ausgabe 1-2/2014 von GMS Medizin - Bibliothek - Information ist dem Thema "Teaching Library: Vermittlung von Informationskompetenz an medizinischen Bibliotheken" gewidmet. Verfasst wurden die Beiträge der Schwerpunktausgabe von Marina Betker & Annette Kustos (Über Angebote zur gesundheitswissenschaftlichen Informationskompetenz in einer neuen Bibliothek - Querfliegen und strategisch Planen: Das Konzept der HSG Bochum), Simone Waldboth (Integration von E-Learning in die Vermittlung von Informationskompetenz an der Claudiana), Michaele Adam & Jens Mittelbach (Mit Informationskompetenz im Forschungsprozess die Zukunft an der SLUB Dresden gestalten), Gregor Steinrisser (Erfolgreiches Scheitern - Fiktion und Friktion einer Teaching Library zwischen Wissenschaft und klinischem Alltag), Melanie Kintzel & Norbert Sunderbrink (Die Vermittlung von Informationskompetenz in der Ärztlichen Zentralbibliothek des Universitätsklinikums Hamburg-Eppendorf), Markus Schmiel (Das Lehr und Lernkonzept der Bibliothek der Medizinischen Hochschule Hannover), Jutta Matrisciano & Martina Semmler-Schmetz (Teaching Library - Umsetzung eines Konzeptes in vielen Facetten an der Bibliothek der Medizinischen Fakultät Mannheim), Karin Cepicka (Teaching Library an der Universitätsbibliothek der Medizinischen Universität Wien), Helmut Dollfuß (Die Lehrveranstaltungen der Bibliothek im neuen Curriculum der Medizinischen Universität Wien), Manuela Rohrmoser & Irene Schachl (Kooperationen der Teaching Library an der Universitätsbibliothek Wien) und Claudia Hausberger & David Frank (Curriculumsreform - ein Arbeitsbericht aus der Universitätsbibliothek der Veterinärmedizinischen Universität Wien).
    Keywords: Teaching Library ; information literacy ; medical library ; learning center ; teaching concept ; training course ; editorial ; Teaching Library ; Informationskompetenz ; Medizinbibliothek ; Lernort ; Lernkonzept ; Schulung ; Editorial ; ddc: 610
    Language: German
    Type: article
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizin - Bibliothek - Information; VOL: 9; DOC01 /20090616/
    Publication Date: 2009-06-17
    Description: The recent issue 1/2009 of GMS Medizin - Bibliothek - Information has a focus on "The green road to open Access: institutional and subject repositories". Self-archiving and storing scholarly publications on a print server were also central topics in many presentations at the 9th International Bielefeld Conference in February 2009. The authors in this issue are Birgit Schmidt and Karin Ilg-Hartecke (Open Access in Deutschland - erweiterte Perspektiven für die Wissenschaft), Christoph Bruch and Anja Lengenfelder (Unterstützung des Grünen Weges zu Open Access an der Max-Planck-Gesellschaft), Ulrich Herb and Matthias Müller (Nuancen in Grün: Betrieb eines institutionellen und disziplinären Repositoriums - Erfahrungen und Entwicklungen an der Saarländischen Universitäts- und Landesbibliothek), Timo Borst and Jan B. Weiland (EconStor: ein fachliches Repositorium für die Wirtschaftswissenschaften), Antonella de Robbio and Michael Katzmayr (The management of an international open access repository: the case of E-LIS) and Christian Gumpenberger (The EPrints story: Southampton as the cradle of institutional self-archiving). Furthermore this focus issue features an interview of a representative of a research funding organisation (Repositorien: Der grüne Weg zu Open Access Publishing aus der Perspektive einer Forschungsförderungsorganisation. 10 Fragen von Bruno Bauer an Falk Reckling, Mitarbeiter des FWF Der Wissenschaftsfonds) and an interview of a publisher (Repositorien: Der grüne Weg zu Open Access Publishing aus der Perspektive der International Association of Scientific, Technical & Medical Publishers (STM): 10 Fragen von Bruno Bauer an Barbara Kalumenos, Director of Public Affairs bei STM).
    Description: Schwerpunktthema der aktuellen Ausgabe 1/2009 von GMS 〈TextGroup〉 Medizin - 〈/TextGroup〉 Bibliothek - Information ist "Der grüne Weg zu Open Access: institutionelle und fachliche Repositorien". Die Selbstarchivierung, das Einbringen wissenschaftlicher Fachpublikation in einen Dokumentenserver, war auch ein zentrales Thema vieler Beiträge der 9. Internationalen Bielefeld Konferenz im Februar 2009. Die Beiträge der aktuellen Schwerpunktausgabe wurden verfasst von Birgit Schmidt und Karin Ilg-Hartecke (Open Access in Deutschland - erweiterte Perspektiven für die Wissenschaft), Christoph Bruch und Anja Lengenfelder (Unterstützung des Grünen Weges zu Open Access an der Max-Planck-Gesellschaft), Ulrich Herb und Matthias Müller (Nuancen in Grün: Betrieb eines institutionellen und disziplinären Repositoriums - Erfahrungen und Entwicklungen an der Saarländischen Universitäts- und Landesbibliothek), Timo Borst und Jan B. Weiland (EconStor: ein fachliches Repositorium für die Wirtschaftswissenschaften), Antonella de Robbio und Michael Katzmayr (The management of an international open access repository: the case of E-LIS), Christian Gumpenberger (The EPrints story: Southampton as the cradle of institutional self-archiving). Ergänzt wird die Schwerpunktausgabe durch Interviews, geführt mit jeweils einem Vertreter der Forschungsförderungsorganisationen (Repositorien: Der grüne Weg zu Open Access Publishing aus der Perspektive einer Forschungsförderungsorganisation. 10 Fragen von Bruno Bauer an Falk Reckling, Mitarbeiter des FWF Der Wissenschaftsfonds) bzw. der Verlage (Repositorien: Der grüne Weg zu Open Access Publishing aus der Perspektive der International Association of Scientific, Technical & Medical Publishers (STM): 10 Fragen von Bruno Bauer an Barbara Kalumenos, Director of Public Affairs bei STM).
    Keywords: open access publishing ; grean road to open access ; self-archiving ; institutional respository ; subject repository ; 9th Bielefeld Conference 2009 ; editorial ; Open Access Publishing ; grüner Weg zu Open Access ; Selbstarchivierung ; institutionelles Repositorium ; fachliches Repositorium ; 9. Bielefeld Konferenz 2009 ; Editorial ; ddc: 610
    Language: German
    Type: article
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  • 5
    Keywords: brain ; CELLS ; EXPRESSION ; SURVIVAL ; tumor ; TUMOR-CELLS ; BLOOD ; CELL ; Germany ; THERAPY ; DISEASE ; LONG-TERM ; TUMORS ; TIME ; PATIENT ; INFECTION ; prognosis ; SKIN ; T cell ; T cells ; T-CELL ; T-CELLS ; cell culture ; culture ; MEMORY ; virus ; NERVOUS-SYSTEM ; NO ; immunohistochemistry ; ASSAY ; NUMBER ; VACCINE ; SAFETY ; CD8(+) ; immune response ; IMMUNE-RESPONSE ; IMMUNITY ; T-LYMPHOCYTES ; vaccination ; T lymphocyte ; side effects ; NEWCASTLE-DISEASE VIRUS ; ESTABLISHMENT ; TUMOR CELLS ; LONG-TERM SURVIVORS ; GLIOMAS ; T lymphocytes ; IMMUNIZATION ; ONCOLOGY ; AUTOLOGOUS TUMOR ; overall survival ; NEWCASTLE-DISEASE-VIRUS ; SURVIVORS
    Abstract: Purpose Prognosis of patients with glioblastoma is poor. Therefore, in glioblastoma patients, we analyzed whether antitumor vaccination with a virus-modified autologous tumor cell vaccine is feasible and safe. Also, we determined the influence on progression-free survival and overall survival and on vaccination-induced antitumor reactivity. Patients and Methods In a nonrandomized study, 23 patients were vaccinated and compared with nonvaccinated controls (n = 87). Vaccine was prepared from patient's tumor cell cultures by infection of the cells with Newcastle Disease Virus, followed by gamma-irradiation, and applied up to eight times. Antitumor immune reactivity was determined in skin, blood, and relapsed tumor by delayed-type hypersensitivity skin reaction, ELISPOT assay, and immunohistochemistry, respectively. Results Establishment of tumor cell cultures was successful in approximately 90% of patients. After vaccination, we observed no severe side effects. The median progression-free survival of vaccinated patients was 40 weeks (v 26 weeks in controls; log-rank test, P =.024), and the median overall survival of vaccinated patients was 100 weeks (v 49 weeks in controls; log-rank test, P 〈.001). Forty-five percent of the controls survived 1 year, 11% survived 2 years, and there were no long-term survivors (greater than or equal to3 years). Ninety-one percent of vaccinated 39% survived 2 years, and 4% were long-term survivors. In the patients survived I year, vaccinated group, immune monitoring revealed significant increases of delayed-type hypersensitivity reactivity, numbers of tumor-reactive memory T cells, and numbers of CD8(+) tumor-infiltrating T-lymphocytes in secondary tumors. Conclusion Postoperative vaccination with virus-modified autologous tumor cells seems to be feasible and safe and to improve the prognosis of patients with gliobiastomas. This could be substantiated by the observed antitumor immune response. (C) 2004 by American Society of Clinical Oncology
    Type of Publication: Journal article published
    PubMed ID: 15452186
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  • 6
    Keywords: CANCER ; CELLS ; EXPRESSION ; tumor ; TUMOR-CELLS ; carcinoma ; CELL ; Germany ; neoplasms ; DIAGNOSIS ; NEW-YORK ; microarray ; transcription ; TISSUE ; DNA ; MICROARRAY DATA ; MUTATIONS ; Jun ; PHENOTYPE ; vimentin ; HEAD ; adenocarcinoma ; pathology ; BEHAVIOR ; MICROARRAY ANALYSIS ; expression profiling ; TUMOR CELLS ; DIFFERENTIAL-DIAGNOSIS ; CELL CARCINOMA ; OF-THE-LITERATURE ; pancreas ; review ; DUCTAL ADENOCARCINOMA ; AUTOPSY ; analysis ; pancreatic ; TUMOR-CELL ; GENOTYPE ; DNA-MICROARRAY ; USA ; pancreatic ductal adenocarcinoma ; MYOEPITHELIAL CARCINOMA ; pancreatic neoplasm ; PSEUDOPAPILLARY TUMORS
    Abstract: Pancreatic neoplasms have been reliably classified on the basis of their histopathology and immunophenotype. In this study, we report on a pancreatic tumor whose phenotype and genotype could not be assigned to any known tumor entity. The tumor was observed in the pancreatic head of a 54-year-old woman. It was found to be a solid infiltrating carcinoma with abundant clear cells. Apart from cytokeratin, the tumor cells expressed vimentin, S100, and MUC-1. DNA microarray analysis revealed a transcription profile clearly differing from that of normal pancreatic tissue and pancreatic ductal adenocarcinoma. Despite metastatic behavior, the tumor displayed a more favorable course than conventional pancreatic ductal adenocarcinoma. We suggest that this tumor be called solid type clear cell carcinoma of the pancreas
    Type of Publication: Journal article published
    PubMed ID: 17453235
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  • 7
    Keywords: CANCER ; tumor ; CELL ; Germany ; human ; SYSTEM ; SYSTEMS ; DISEASE ; liver ; PROTEIN ; PROTEINS ; SAMPLE ; SAMPLES ; MOLECULES ; TISSUE ; TISSUES ; BIOLOGY ; MOLECULE ; IDENTIFICATION ; MEMBRANE ; INSTABILITY ; ELECTROPHORESIS ; pancreatic cancer ; SECTIONS ; molecular biology ; pancreas ; PANCREATIC-CANCER ; EXTRACTION ; SEPARATION ; USA ; protein fractionation ; CELL-CELL ; EFFECTOR MOLECULE ; ISLETS ; protein extraction
    Abstract: Proteins are the major class of effector molecules in cellular systems. For the identification of functional differences between normal and diseased tissues, a reliable analysis of their protein content is essential. Reproducible isolation and fractionation of intact proteins are important in this respect, but their complexity in structure and concentration, their close interaction, and their instability represent major challenges. For protein isolation in tissues, the breakdown of cell-cell and cell-matrix connections within a tissue without affecting protein quality is a critical factor. We compared different processes for a compartmental protein preparation from pancreatic tissue, one of the most challenging tissues for protein isolation because of its high protease content. Success of the different procedures varied greatly. Based on a scheme of tissue-slicing and subsequent cell isolation, we established a reliable workflow for the fractional extraction of cytosolic proteins, membrane and organelle proteins, nuclear proteins, and cytoskeletal filaments. The tissue slices also allow for a representative confirmation of individual samples' cellular status by histochemical processes, and a proper separation or mixing of cellular material from across a tumor if required
    Type of Publication: Journal article published
    PubMed ID: 19450236
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  • 8
    Keywords: CANCER ; COMBINATION ; Germany ; LUNG ; SYSTEM ; SYSTEMS ; liver ; GENOME ; microarray ; PROTEIN ; PROTEINS ; TISSUE ; HEART ; QUALITY ; RAT ; antibody ; DESIGN ; MEMBRANE ; PROTEOMICS ; PANCREATIC-CANCER ; 2-DIMENSIONAL ELECTROPHORESIS ; antibody microarray ; FUNCTIONALITY ; MEMBRANE-PROTEINS ; protein extraction ; compartmentalized protein ; DETERGENTS
    Abstract: The process of extracting comprehensive proteome representations is a crucial step for many proteomic studies. While antibody microarrays are an evolving and promising methodology in proteomics, the issue of protein extraction from tissues for this kind of analysis has never been addressed. Here, we describe a single-step extraction buffer for the isolation of proteins from mammalian tissues under native conditions in an effective and reproducible manner. Protein was extracted from cell lines BxPC-3 and SU.86.86, rat organs (pancreas, liver, heart and lung) and human pancreatic cancer tissues using several buffer systems that contained individual nonionic or zwitterionic detergents in comparison to commercial extraction buffers. Also, detergent combinations were used that included at least one polymeric phenylethylene glycol, a long-chain amidosulfobetaine, cholate and a zwitterionic detergent. Extracts were analyzed for protein quantity and quality. The detergent cocktails exhibited superior extraction capacity. Additionally, they demonstrated a substantially higher recovery of membrane and compartmental proteins as well as much better preservation of protein functionality. Also, they did not interfere with subsequent analysis steps such as labeling. In Western blot and antibody microarray assays, they outperformed the other buffer systems, indicating that they should also be useful for other types of proteomic studies
    Type of Publication: Journal article published
    PubMed ID: 20047340
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  • 9
    Keywords: RECEPTOR ; EXPRESSION ; GROWTH ; IN-VITRO ; INHIBITOR ; CELL ; Germany ; INHIBITION ; PATHWAY ; PATHWAYS ; DISEASE ; GENE ; GENE-EXPRESSION ; GENES ; microarray ; PROTEIN ; METABOLISM ; LINES ; NF-KAPPA-B ; NITRIC-OXIDE ; MACROPHAGES ; TARGET ; MOUSE ; ASSAY ; microarrays ; NECROSIS-FACTOR-ALPHA ; CELL-LINE ; LINE ; PROGNOSTIC VALUE ; TARGETS ; inflammation ; CYTOTOXICITY ; INCREASED EXPRESSION ; INHIBITORS ; CELL-GROWTH ; signaling ; INTERFERENCE ; SCIENCE ; pharmacology ; nitric oxide ; NITROSATIVE STRESS ; INTERLEUKIN-10 ; TUMOR BIOLOGY ; NATURAL-PRODUCTS ; POOR SURVIVAL ; natural product ; Glucocorticoid receptor signaling pathway ; Griess assay ; Interleukin-10 signaling pathway ; RAW-264.7 CELLS ; THIOREDOXIN SYSTEM
    Abstract: Nitric oxide (NO) plays a role in various physiological and pathophysiological conditions such as immunoregulatory and inflammatory processes. Hence, NO and its generating enzyme, inducible nitric oxide synthase (iNOS) may not only be of diagnostic and prognostic value, but may also serve as targets for novel therapeutic options. In the present investigation, we have screened a phytochemical library by correlating the IC50 values for 531 natural products of 60 cell lines with the microarray-based mRNA expression of 95 genes known to be involved in NO metabolism and signaling with the aim to identify candidate compounds as inhibitors for NO metabolism and signaling. We identified bis(helenalinyl)glutarate (BHG) as putative candidate compound. Indeed. BHG inhibited NO production (IC50 value: 0.90 +/- 0.04 mu M) and down-regulated iNOS protein expression (IC50 value: 1.12 +/- 0.16 mu M) of RAW264.7 mouse macrophages in the presence of lipopolysaccharide. Performing XTT cytotoxicity assays, we found that BHG inhibited cell growth in a dose-dependent manner with an IC50 value of 5.6 mu M. To gain insight into molecular pathways involved in NO inhibition and cytotoxicity, we performed microarray experiments which were exemplarily validated by real-time RT-PCR. A total of 227 genes (67 up- and 160 down-regulated) were obtained, which exhibited significant differences in mRNA regulation between BHG-treated and untreated RAW264.7 macrophages. Sixteen of 227 genes are known to be involved in NO-signaling. Pathway analyses revealed that further five and four down-regulated genes belong to the glucocorticoid receptor and interleukin-1 and interleukin-10 pathways, respectively. An interference of these two pathways and NO is known for inflammation and auto-immune diseases. The therapeutic potential of this compound has to be explored in the future. (C) 2010 Elsevier Inc. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 20105431
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  • 10
    Keywords: CANCER ; EXPRESSION ; Germany ; RISK ; GENE ; GENE-EXPRESSION ; GENES ; TUMORS ; PROGRESSION ; PATTERNS ; gene expression ; genetics ; DELETIONS ; REGION ; PHENOTYPE ; MICROARRAY ANALYSIS ; METHYLATION ; neuroblastoma ; ONCOLOGY ; PATTERN ; CANDIDATE GENES ; DNA COPY NUMBER ; SUBTYPES ; EXPRESSION PROFILES ; HIGH-RESOLUTION ANALYSIS ; SUBGROUPS ; outcome ; CELL BIOLOGY ; Genetic ; 4S NEUROBLASTOMA ; integrative genomics ; loss of 11q
    Abstract: Imbalances in chromosome 11q occur in approximately 30% of primary neuroblastoma and are associated with poor outcome. It has been suggested that 11q loss constitutes a distinct clinico-genetic neuroblastoma subgroup by affecting expression levels of corresponding genes. This study analysed the relationship of 11q loss, clinical phenotype and global transcriptomic profiles in four clinico-genetic subgroups (11q alteration/favourable outcome, n = 7; 11q alteration/unfavourable outcome, n 14; no 11q alteration/favourable outcome, n 81; no 11q alteration/unfavourable outcome, n 8; tumours with MYCN amplification and/or 1p loss were excluded). Unsupervised and supervised comparisons of gene expression profiles consistently showed significantly different mRNA patterns between favourable and unfavourable neuroblastomas, both in the subgroups with and without 11q loss. In contrast, favourable tumours with and without 11q loss showed highly similar transcriptomic profiles. Disproportionate downregulation of 11q genes was observed only in unfavourable tumours with 11q loss. The diverging molecular profiles were neither caused by considerable differences in the size of the deleted regions nor by differential methylation patterns of 11q genes. Together, this study shows that neuroblastoma with 11q loss comprises two biological subgroups that differ both in their clinical phenotype and gene expression patterns, indicating that 11q loss is not a primary determinant of neuroblastoma tumour behaviour. Oncogene (2010) 29, 865-875; doi:10.1038/onc.2009.390; published online 9 November 2009
    Type of Publication: Journal article published
    PubMed ID: 19901960
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