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  • 1
    Abstract: Objective To identify genetic and nongenetic risk factors that contribute to the severity of the bladder exstrophy-epispadias complex (BEEC). Study design Patients with BEEC from North America (n = 167) and Europe (n = 274) were included. The following data were collected: associated anomalies, parental age at conception, mode of conception, periconceptional folic acid supplementation, maternal risk factors during pregnancy, and environmental risk factors. The patients were divided into 3 subgroups according to phenotype severity: (i) mild, epispadias (n = 43); (ii) intermediate, classic bladder exstrophy (n = 366); and (iii) severe, cloacal exstrophy (n = 31). These subgroups then were compared with identify factors that contribute to phenotype severity. Results Males were overrepresented in all subgroups. A relatively high prevalence of cleft lip, with or without cleft palate, was observed. Maternal smoking and medical radiation during the first trimester were associated with the severe cloacal exstrophy phenotype. Compliance with periconceptional folic acid supplementation was associated with the mildest phenotype (epispadias). Conclusions Periconceptional folic acid supplementation appears to prevent the development of the severe phenotype of BEEC.
    Type of Publication: Journal article published
    PubMed ID: 21679965
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  • 2
    Electronic Resource
    Electronic Resource
    Langenbeck's archives of surgery 369 (1986), S. 847-847 
    ISSN: 1435-2451
    Keywords: Abdominal aortic aneurysm ; Diagnosis ; Indication ; Operations ; Bauchaortenaneurysma ; Diagnose ; Indikation ; Operation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An der II. Chirurgischen Abteilung des AK Harburg wurden in 5 Jahren (1981–1985) 263 Patienten mit einem infrarenalen Bauchaortenaneurysma operiert. Im vorliegenden Film werden die Diagnostik beim Bauchaortenaneurysma, die Untersuchungstechnik und -taktik beim Hausarzt und in der Klinik vorgestellt sowie die Operation zweier Aneurysmen gezeigt. Postoperative Probleme, Risikofaktoren und Kontraindikationen zur Operation werden diskutiert.
    Notes: Summary At the 2nd Surgical Department of the Harburg General Hospital in Hamburg, Germany, 263 patients with infrarenal abdominal aortic aneurysms were operated on during a 5-year period from 1981 to 1985. The film demonstrates diagnostic procedures and evaluation techniques, as employed by the family physician and the clinician. Moreover, operations for two abdominal aneurysms are shown. Postoperative problems, risk factors, and contraindications against operative procedures are discussed.
    Type of Medium: Electronic Resource
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