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  • COLON-CANCER  (2)
  • IV heparin prophylaxis  (2)
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  • 1
    Keywords: CANCER ; SURVIVAL ; tumor ; Germany ; THERAPY ; TOXICITY ; FOLLOW-UP ; COHORT ; DRUG ; MONOCLONAL-ANTIBODY ; PATIENT ; murine ; colon ; treatment ; antibodies ; antibody ; GLYCOPROTEIN ; TRIAL ; COLON-CANCER ; MONOCLONAL-ANTIBODIES ; FLUOROURACIL ; folinic acid ; ONCOLOGY ; colon cancer ; overall survival ; ADJUVANT THERAPY ; SWITZERLAND ; methods ; PHASE ; monoclonal antibodies ; monoclonal antibody ; edrecolomab ; MONOCLONAL-ANTIBODY THERAPY ; stage II
    Abstract: Background: In a phase III study recruiting patients with stage II colon cancer the effect of adjuvant therapy with edrecolomab, a murine monoclonal antibody to the cell-surface glycoprotein 17-1A, was compared to observation alone. Patients and Methods: From January 1997 until July 2000 a total of 377 patients were postoperatively stratified according to tumor stage (T3 vs. T4) and center, and randomly allocated to either treatment with edrecolomab ( cohort A, n = 183) or observation ( cohort B, n = 194). Patients in cohort A received a total of 900 mg edrecolomab. The study was terminated prematurely because of discontinuation of drug supply in Germany. Results: 305 patients were eligible for the primary endpoint of overall survival and 282 patients for disease-free survival. After a median follow-up of 42 months overall survival and disease-free survival were not significantly different. Toxicity was mild. Conclusions: In the present study, postoperative adjuvant treatment with edrecolomab in patients with resected stage II colon cancer did not improve overall or disease-free survival
    Type of Publication: Journal article published
    PubMed ID: 15933423
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  • 2
    Keywords: CANCER ; CANCER CELLS ; CELLS ; tumor ; CELL ; COMBINATION ; Germany ; IN-VIVO ; MICROSCOPY ; THERAPY ; VOLUME ; GENE ; gene therapy ; MICE ; ACTIVATION ; prognosis ; colon ; INJECTION ; treatment ; BREAST-CANCER ; PROMOTER ; genetics ; colorectal cancer ; COLORECTAL-CANCER ; chemotherapy ; CANCER-CELLS ; COLON-CANCER ; FLUORESCENCE ; GENE-THERAPY ; GREEN FLUORESCENT PROTEIN ; heredity ; CYP2B1 ; ifosfamide ; ACTIVATING CYTOCHROME-P450 ; cytochrome P450 ; ONCOLOGY ; colon cancer ; QUALITY-OF-LIFE ; ENZYME ; SULFATE ; HISTOLOGY ; COMPOUND ; CANCER-TREATMENT ; animal ; viability ; cytomegalovirus ; FORMULATION ; INTRAPERITONEAL HYPERTHERMIC CHEMOTHERAPY ; ISOPHOSPHORAMIDE MUSTARD ; LAPAROSCOPIC FLUORESCENCE DIAGNOSIS ; peritoneal carcinomatosis ; TARGETED CHEMOTHERAPY
    Abstract: The prognosis of peritoneal spread from gastrointestinal cancer and subsequent malignant ascites is poor, and current medical treatments available are mostly ineffective. Targeted chemotherapy with intraperitoneal prodrug activation may be a beneficial new approach. L293 cells were genetically modified to express the cytochrome P450 enzyme 2B1 under the control of a cytomegalovirus immediate early promoter. This CYP2B1 enzyme converts ifosfamide to its active cytotoxic compounds. The cells are encapsulated in a cellulose sulfate formulation (Capcell(TM)). Adult Balb/c mice were inoculated intraperitoneally with 1 x 10(6) colon 26 cancer cells, previously transfected with GFP to emit a stable green fluorescence, by injection into the left lower abdominal quadrant. Two or five day's later animals were randomly subjected to either i.p. treatment with ifosfamide alone or ifosfamide combined with microencapsulated CYP2B1-expressing cells. Peritoneal tumor volume and tumor viability were assessed 10 days after tumor inoculation by means of fluorescence microscopy, spectroscopy and histology. Early i.p. treatment with ifosfamide and CYP2B1 cells resulted in a complete response. Treatment starting on day 5 and single-drug treatment with ifosfamide resulted in a partial response. These results suggest that targeted i.p. chemotherapy using a combination of a prodrug and its converting enzyme may be a successful treatment strategy for peritoneal spread from colorectal cancer
    Type of Publication: Journal article published
    PubMed ID: 16096652
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  • 3
    ISSN: 1435-2451
    Keywords: Multiple trauma patients ; IV heparin prophylaxis ; Thrombo-embolic complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Risiko thromboembolischer Komplikationen ist beim Polytrauma infolge verschiedener pathophysiologischer Vorgänge erhöht. Ziel dieser Studie war es den Einfluß einer kontinuierlichen IV Heparin-Prophylaxe (10 000 IE/24h) beim Polytrauma zu untersuchen. Retrospektiv wurden 72 obduzierte Todesfälle von 373 Polytraumen aus den Jahren 1984 und 1985 analysiert. Bei einem Patienten waren multiple periphere Makrolungenembolien für den Tod mitverantwortlich. Fulminante Lungenembolien, Becken- und tiefe Beinvenenthrombosen wurden im Sektionsgut nicht gefunden.
    Notes: Summary The risk of thrombo-embolic complications in multiple injured patients is increased due to several pathophysiological factors. The purpose of this study was to analyse the effect of a continuous IV heparin prophylaxis (10000IE/24h) in polytraumatized patients. A post-mortem evaluation of 72 deceased patients out of 373 multiple trauma patients treated during 1984–1985 was performed. In one patient multiple major pulmonary emboli were found to contribute to his death. No deep vein thrombosis as well as no fulminant pulmonary embolism were found in any case.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1435-2451
    Keywords: Multiple trauma patients ; IV heparin prophylaxis ; Thromboembolic complications ; Polytrauma ; Heparin-Prophylaxe ; Lungenemboliehliufigkeit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Risiko thromboembolischer Komplikationen ist beim Polytrauma infolge verschiedener pathophysiologischer Vorgänge erhöht. Ziel dieser Studie war es, den Einfluss einer kontinuierlichen IV Heparin Prophylaxe (10 000 IE/24 h) beim Polytrauma zu untersuchen. Retrospektiv wurden 72 obduzierte Todesfälle von 373 Polytraumen aus den Jahren 1984 und 1985 analysiert. Bei einem Patienten waren multiple periphere Makrolungenembolien für den Tod mitverantwortlich. Fulminante Lungenembolien, Becken- und tiefe Beinvenenthrombosen wurden im Sektionsgut nicht gefunden.
    Notes: Summary The risk of thromboembolic complications is increased in patients with multiple injuries patients due to several pathophysiological factors. The purpose of this study was to analyze the effect of continuous IV heparin prophylaxis (10,000 IU/24 h) in patients with polytrauma. A postmortem evaluation was performed based on 72 deceased patients out of 373 multiple trauma patients treated during 1984–1985. In one patient, multiple major pulmonary emboli were found to contribute to his death. No deep vein thrombosis or fulminant pulmonary embolism was found in any of the cases.
    Type of Medium: Electronic Resource
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