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  • Springer eBooks  (3)
  • Cadherins  (2)
  • 1
    Keywords: Medicine ; Pharmaceutical technology ; Biomedicine ; Pharmaceutical Sciences/Technology ; Springer eBooks
    Description / Table of Contents: 1 Hydrophilic Matrix Dosage Forms: Definitions, General Attributes and the Evolution of Clinical Utilization -- 2 Design and Evaluation of Hydroxypropyl Methylcellulose Matrix Tablets for Oral Controlled Release: a Historical Perspective -- 3 An Industrial Perspective on Hydrophilic Matrix Tablets based on Hyproxypropyl Methylcellulose (Hypromellose) -- 4 Natural Polysaccharides in Hydrophilic Matrices -- 5 Applications of Polyethylene Oxide (POLYOX) in Hydrophilic Matrices -- 6 A Formulation Development Perspective on Critical Interactions Affecting the Performance of Hydrophilic Matrix Tablets -- 7 In vitro Physical and Imaging Techniques to Evaluate Drug Release Mechanisms from Hydrophilic Matrix Tablets -- 8 Physiologically-Based Pharmacokinetic Modelling in the Development and Evaluation of Hydrophilic Matrix Tablets -- 9 Approaches to Rapid In Vivo Optimization of Hydrophilic Matrix Tablets -- 10 Extrusion: an Enabling Technology for Controlled Release Hydrophilic Matrix Systems -- 11 Microenvironmental pH Control and Mixed Polymer Approaches to Optimize Drug Delivery with Hydrophilic Matrix Tablets -- 12 Evolving Biopharmaceutics Perspectives for Hydrophilic Matrix Tablets: Dosage Form-Food Interactions and Dosage Form Gastrointestinal Tract Interactions
    Abstract: This detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release. It brings together information from more than five decades of research and development on hydrophilic matrix tablets and provides perspective on contemporary issues.Twelve comprehensive chapters explore a variety of topics including polymers (hypromellose, natural polysaccharides and polyethylene oxide) and their utilization in hydrophilic matrices, critical interactions impacting tablet performance, in vitro physical and imaging techniques, and microenvironmental pH control and mixed polymer approaches, among others. In one collective volume, Hydrophilic Matrix Tablets for Oral Controlled Release provides a single source of current knowledge, including sections of previously unpublished data. It is an important resource for industrial and academic scientists investigating and developing these oral controlled release formulations
    Pages: IX, 326 p. 102 illus., 37 illus. in color. : online resource.
    ISBN: 9781493915194
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  • 2
    Keywords: Chemistry ; Biotechnology ; Microreactors ; Chemistry ; Biotechnology ; Microengineering ; Springer eBooks
    Abstract: Microfluidic techniques are becoming widely incorporated into medical diagnostic systems due to the inherent advantages of miniaturization. In Microfluidic Diagnostics: Methods in Molecular Biology, researchers in the field detail methods and protocols covering subjects such as microfluidic device fabrication, on-chip sample preparation, diagnostic applications and detection methodologies. The protocols described range from cutting-edge developments to established techniques and basic demonstrations suitable for education and training; from basic fabrication methods to commercializing research. Written in the highly successful Methods in Molecular Biologý„Ø series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. ℗ Authoritative and practical, Microfluidic Diagnostics: Methods in Molecular Biology seeks to aid scientists in the further development and commercialization of microfluidic diagnostic technologies
    Pages: XIII, 525 p. 143 illus., 58 illus. in color. : digital.
    ISBN: 9781627031349
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  • 3
    Keywords: Medicine ; Gastroenterology ; Nursing ; Oncology ; Pain Medicine ; Surgery ; Medicine & Public Health ; Gastroenterology ; Pain Medicine ; Oncology ; Surgery ; Nursing Management/Nursing Research ; Springer eBooks
    Pages: : digital
    ISBN: 9781848821187
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  • 4
    ISSN: 0002-9106
    Keywords: Cadherins ; Integrins ; N-CAM ; Fibronectin ; Myoblasts ; Myogenesis ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: N-cadherin, N-CAM, fibronectin, and β1-integrins have been implicated in the control of myoblast fusion to form multinucleate myotubes, a critical step in the terminal differentiation of skeletal muscle. We have analyzed the temporal pattern of expression of mRNA transcripts encoding these adhesion molecules during the terminal differentiation of C2 mouse myoblasts. The accumulation of mRNA transcripts encoding N-cadherin, N-CAM, fibronectin, β5-integrin, and β1-integrin subunits was developmentally, but not coordinately, regulated. N-cadherin and integrin subunit expression was maximal in profusion myoblasts and declined thereafter. In contrast, N-CAM mRNA levels were low in prefusion myoblasts, and increased coincident with the onset of terminal differentiation. Fibronectin mRNA levels were also low in myoblasts, and they did not increase until after cell fusion had occurred. The results indicate that despite their lack of coordinate regulation maximal levels of mRNA transcripts encoding adhesion molecules are present at a stage which corresponds to the peak of the active phase of myoblast fusion. © 1992 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 16 (1995), S. 20-24 
    ISSN: 0192-253X
    Keywords: Cadherins ; ovary ; granulosa cells ; steroids ; cell adhesion molecules ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: N-cadherin (N-cad) is a calcium-dependent cell adhesion molecule which is present in the granulosa cells of the mouse ovarian follicle. This cell adhesion molecule has been implicated as a key modulator of follicular development. The regulators of N-cad mRNA levels in the ovary have not been identified. We have examined the ability of steroids to influence ovarian N-cad mRNA levels in vivo. Immature mice were injected with either progesterone, testosterone, 17β-estradiol, or 17α-estradiol. Only 17β-estradiol caused a rapid and significant increase in the ovarian N-cad mRNA levels. We speculate that this steroid is a major regulator of N-cad-mediated granulosa cell interactions in vivo. © 1995 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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