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  • Albuminuria  (1)
  • Blood pressure  (1)
  • Bronchoalveolar lavage fluid (BALF)  (1)
  • Cancer pain  (1)
  • Springer  (4)
  • Macmillian Magazines Ltd.
  • Blackwell Publishing Ltd
  • German Medical Science; Düsseldorf, Köln
  • Elsevier
Collection
Publisher
  • Springer  (4)
  • Macmillian Magazines Ltd.
  • Blackwell Publishing Ltd
  • German Medical Science; Düsseldorf, Köln
  • Elsevier
Years
  • 1
    ISSN: 1432-1238
    Keywords: Key words Apnoea testing ; Brain death ; Blood pressure ; Heart rate ; Cardiovascular changes ; Transcutaneous blood gas monitoring ; CO2 insufflation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To determine changes of blood pressure and heart rate during apnoea testing for brain death without (A) and with (B) artificial CO2 augmentation. Design: Prospective, consecutive study. Setting: 12 intensive care units in six towns in Northern Bavaria. Patients and participants: A total of 55 apnoea tests were performed on 55 consecutive patients as part of the determination of brain death, 27 without and 28 with CO2 augmentation. Interventions: Apnoea tests following oxygenation with 100 % O2 either after reduction of ventilatory volume (A) or after insufflation of CO2 during normoventilation (B). In each case, an arterial partial CO2 pressure of at least 8 kPa was documented. Results: All apnoea tests were without serious adverse effects (hypoxia, newly induced cardiac arrhythmia, cardiac asystole). An increased dopamine infusion rate was deemed necessary in only one case of group (A) because of marked systolic hypotension ( 〈 8 kPa). Individual variation of systolic and diastolic blood pressure (BP) did not exceed + 62 to –46 % and + 49 to –52 % respectively, in group (A) and + 35 to –57 % and + 40 to –48 % respectively, in group (B). Variation of heart rate (HR) remained within the range + 24 to –31 % in group (A) and + 37 to –22 % in group (B). Conclusions: HR varied less than BP. The possibility of a marked relative rise or fall of BP in group (A) was equal; in group (B) there was a lower chance of rising BP. The chances for a rise or fall in HR were equal for the two groups. There was a tendency for less variation of cardiovascular parameters in group (B).
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  • 2
    ISSN: 1432-2129
    Keywords: Schlüsselwörter Schmerztherapie ; Tumorschmerz ; Kopfschmerz ; Rückenschmerz ; Epidemiologie ; Key words Pain management ; Cancer pain ; Headache ; Back pain ; Epidemiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract In Middle Franconia, one of the larger Bavarian administrative division (population 1994: 1,657,101), the number of patients suffering from cancer pain, chronic headache and chronic back pain is not known. Furthermore, there are no data on interdisciplinary organization of outpatient pain management. Methods: All physicians and psychologists involved in outpatient pain management in Middle Franconia (n=2130) were asked (questionnaires) to estimate the number of patients suffering from cancer pain, chronic (〉6 months) headache and chronic (〉6 months) back pain treated the last 12 months. Results: 264 (12.4%) responses were analyzed; 107,346 patients had been treated in the last 12 months, 67% by a single specialist and 33% by two or more specialists. The participation of psychotherapists and anesthetists in outpatient management of pain patients was poor; 22,754 (21%) patients were thought to need multidisciplinary algesia therapy in a pain clinic, which actually does not exist in Middle Franconia. Conclusion: The data presented suggest that patients suffering from chronic pain are not optimally managed in Middle Franconia. Regional institutions for multidisciplinary pain treatment have to be established close to where chronic pain patients live.
    Notes: Zusammenfassung Zur orientierenden Schätzung der ambulanten Versorgung von Patienten mit Tumor-, Kopf- und Rückenschmerzen im bayerischen Regierungsbezirk Mittelfranken wurden im Oktober 1995 an alle an der ambulanten Behandlung von Patienten beteiligten Ärzte und nichtärztlichen Psychotherapeuten dieser Region (n=2130) Fragebögen gesandt. 264 Kollegen (12,4%) lieferten auswertbare Angaben. Von diesen Kollegen wurden in den letzten 12 Monaten 107 346 Patienten mit chronischen Schmerzen behandelt. Davon wurden 72 255 Patienten (67%) monodisziplinär und 35 091 Patienten (33%) ambulant-interdisziplinär behandelt. Der Anteil der Psychotherapeuten und Anästhesisten an der ambulanten Diagnostik und Therapie von Schmerzpatienten war gering. Bei 22 754 Patienten (21%) wurde aufgrund der Therapieresistenz der Beschwerden unter ambulanten Bedingungen eine multidisziplinäre algesiologische Diagnostik und Therapie unter stationären oder teilstationären Bedingungen für notwendig erachtet. Derartige Einrichtungen bestehen derzeit in Mittelfranken nicht. Die Zahl problematischer Schmerzpatienten ist als Mindestzahl aufzufassen und unterstreicht die Notwendigkeit, wohnortnah adäquate schmerztherapeutische Behandlungseinrichtungen aufzubauen.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-5233
    Keywords: Key words Experimental diabetes ; Albuminuria ; Glomerular metabolism ; ACE inhibitors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clinical studies indicate a nephro-protective effect in conjunction with the use of ACE inhibitors. This study's aim was to determine whether ACE inhibitors influence the metabolism of glomerular cells in addition to their known hemodynamic effects. Streptozotocin diabetic rats were treated with lisinopril (DLis 1.5 mg/l water), or hydralazine (Dhyd, 50 mg/l water) over 4 weeks. Untreated diabetic rats (DC) and non-diabetic rats (C) served as controls. After four weeks of treatment, urinary excretion of albumin, blood pressure and metabolic control (Glyc-Hb) were measured. After treatment glomeruli were isolated and homogenized, and β-NAG and total proteolytic activity against azocasein were measured. Glycated hemoglobin levels were similar in all diabetic groups (DC, 12%, Dhyd, 10%; DLis 11%). Blood pressure of DLis rats (79 ± 3 mmHg) and DHyd rats (46 ± 2 mmHg) was lower than that of DC rats (111 ± 3 mmHg). Urinary albumin excretion of diabetic groups was lowest in DLis. Diabetic rats showed a decrease in glomerular β-NAG (10 vs. 60.5 U/g protein) and total proteolytic activity against azocasein (148 vs. 170 U/mg protein hour) compared to non-diabetic rats. Lisinopril increased β-NAG (30 vs. 14 U/g protein) and total proteolytic activity (160.5 vs. 141.5 U/mg protein hour) compared with hydralazine. Our study confirms that the nephro-protective effect of ACE inhibitors is partially due to modulatory effects on the metabolism of basement membrane proteins.
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  • 4
    ISSN: 1432-1750
    Keywords: Pneumoconiosis ; N-acetyl-β-D-glucosaminidase ; Bronchoalveolar lavage fluid (BALF) ; Disease models ; Animal macrophages
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract N-acetyl-beta(β)-D-glucosaminidase is a lysosomal enzyme secreted by alveolar macrophages in response to phagocytosis of particulate material. Alveolar macrophages participate in the degradation and fibrosis of pulmonary tissue that results in pneumoconiosis. Known quantities of four characterized respirable dusts were bronchoscopically placed into the right caudal lung lobe of macaque monkeys. Bronchoalveolar lavage (BAL) samples were collected from dust-exposed right lung and unexposed left lung of the same individuals at 2-week intervals for 12 weeks after dust instillation. The samples were tested for N-acetyl-β-D-glucosaminidase activity to determine if the enzyme levels could serve as an indicator of pulmonary injury induced by generic coal dusts when compared to known fibrogenic and nuisance dusts. Installation of generic quartz, anthracite, or TiO2 dusts produced significant elevations of enzyme activity and increased numbers of macrophages in the dust-exposed lobes. Elevations in enzymatic activity and macrophage numbers were greatest in response to generic quartz dust. These results suggest that quantitative levels of N-acetyl-β-D-glucosaminidase activity may be a useful indicator of acute and chronic lung injury following exposure to fibrogenic and nonfibrogenic dusts.
    Type of Medium: Electronic Resource
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