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  • 1
    Electronic Resource
    Electronic Resource
    The European physical journal 26 (1993), S. 119-125 
    ISSN: 1434-6079
    Keywords: 36.40.+d ; 31.20.Sy ; 32.80.Dz ; 71.10.+x
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Theoretical investigations of size evolutionary patterns for multiply charged anionic metal clusters and solvation of sodium in water clusters are discussed. For Na N Z- clusters, energetic stability and electron decay channels are determined. Formation of a “surface Rydberg-like state” in Na(H2O) N , correlating with calculated and measured ionization potentials, is analyzed.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2013-01-11
    Description: Mutational activation of BRAF is the most prevalent genetic alteration in human melanoma, with 〉/=50% of tumours expressing the BRAF(V600E) oncoprotein. Moreover, the marked tumour regression and improved survival of late-stage BRAF-mutated melanoma patients in response to treatment with vemurafenib demonstrates the essential role of oncogenic BRAF in melanoma maintenance. However, as most patients relapse with lethal drug-resistant disease, understanding and preventing mechanism(s) of resistance is critical to providing improved therapy. Here we investigate the cause and consequences of vemurafenib resistance using two independently derived primary human melanoma xenograft models in which drug resistance is selected by continuous vemurafenib administration. In one of these models, resistant tumours show continued dependency on BRAF(V600E)--〉MEK--〉ERK signalling owing to elevated BRAF(V600E) expression. Most importantly, we demonstrate that vemurafenib-resistant melanomas become drug dependent for their continued proliferation, such that cessation of drug administration leads to regression of established drug-resistant tumours. We further demonstrate that a discontinuous dosing strategy, which exploits the fitness disadvantage displayed by drug-resistant cells in the absence of the drug, forestalls the onset of lethal drug-resistant disease. These data highlight the concept that drug-resistant cells may also display drug dependency, such that altered dosing may prevent the emergence of lethal drug resistance. Such observations may contribute to sustaining the durability of the vemurafenib response with the ultimate goal of curative therapy for the subset of melanoma patients with BRAF mutations.〈br /〉〈br /〉〈a href="" target="_blank"〉〈img src="" border="0"〉〈/a〉   〈a href="" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Das Thakur, Meghna -- Salangsang, Fernando -- Landman, Allison S -- Sellers, William R -- Pryer, Nancy K -- Levesque, Mitchell P -- Dummer, Reinhard -- McMahon, Martin -- Stuart, Darrin D -- R01 CA176839/CA/NCI NIH HHS/ -- R01-CA176839/CA/NCI NIH HHS/ -- T32 HL007185/HL/NHLBI NIH HHS/ -- England -- Nature. 2013 Feb 14;494(7436):251-5. doi: 10.1038/nature11814. Epub 2013 Jan 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Novartis Institutes for Biomedical Research, Emeryville, California 94608, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Disease Models, Animal ; Drug Administration Schedule ; Drug Resistance, Neoplasm/*drug effects ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Indoles/*administration & dosage/*adverse effects/pharmacology ; MAP Kinase Signaling System/drug effects ; Melanoma/*drug therapy/genetics/*pathology ; Mice ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Mutation ; Neoplasm Transplantation ; Proto-Oncogene Proteins B-raf/chemistry/genetics/metabolism ; Subcutaneous Tissue ; Sulfonamides/*administration & dosage/*adverse effects/pharmacology ; Time Factors ; Xenograft Model Antitumor Assays
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2011-01-08
    Description: Ammonites are prominent in macroevolutionary studies because of their abundance and diversity in the fossil record, but their paleobiology and position in the marine food web are not well understood due to the lack of preserved soft tissue. We present three-dimensional reconstructions of the buccal apparatus in the Mesozoic ammonite Baculites with the use of synchrotron x-ray microtomography. Buccal mass morphology, combined with the coexistence of food remains found in the buccal mass, suggests that these ammonites fed on plankton. This diet may have extended to all aptychophoran ammonites, which share the same buccal mass morphology. Understanding the role of these ammonites in the Mesozoic food web provides insights into their radiation in the Early Jurassic, as well as their extinction at the end of the Cretaceous/early Paleogene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kruta, Isabelle -- Landman, Neil -- Rouget, Isabelle -- Cecca, Fabrizio -- Tafforeau, Paul -- New York, N.Y. -- Science. 2011 Jan 7;331(6013):70-2. doi: 10.1126/science.1198793.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉UMR-CNRS 7207, Departement Histoire de la Terre, Museum National d'Histoire Naturelle, 47 rue Cuvier, 75231 Paris Cedex 05, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Cephalopoda/*anatomy & histology/physiology ; Diet ; Digestive System ; Extinction, Biological ; Feeding Behavior ; *Food Chain ; *Fossils ; Gastropoda/anatomy & histology ; Isopoda/anatomy & histology ; Jaw/anatomy & histology ; Tooth/anatomy & histology ; X-Ray Microtomography ; *Zooplankton
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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