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  • Antibiotic resistance  (1)
  • Antibiotics  (1)
  • Chemistry  (1)
  • Proliferation  (1)
  • ACI
  • Doppler sonography
  • 1990-1994  (3)
  • 1
    ISSN: 1432-0878
    Keywords: Lung ; Endocrine cells ; Calcitonin generalated peptide ; Bromodeoxyuridine ; Differentiation ; Proliferation ; Hypoxia ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We have tested the suggestion that the reported increase, in hypoxic rats, in the number of lung endocrine cells immunoreactive for the regulatory peptide CGRP is caused by an accumulation of peptide within the cells which renders them more detectable, rather than by a real increase in proliferation. The incorporation of continuously infused 5′-bromodeoxyuridine (BrdU) into nuclei of CGRP-containing cells was studied by immunohistochemistry in the airway and respiratory epithelium of rats kept in a hypoxic (10% O2), normobaric conditions for 7 days and in normoxic, normobaric controls. Some CGRP-immunoreactive cells could also be labelled for BrdU. However, the ratio of the number of cells labelled with both CGRP and BrdU to the number of cells labelled with CGRP alone did not differ significantly between hypoxic and normoxic rats (7.1±0.7 and 6.1±1.2, respectively; mean±SEM; P=0.49). These data strongly suggest that CGRP-containing endocrine cells or their precursors do proliferate in adult rat lung, but that the proliferation is not increased significantly in hypoxia.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0044-2313
    Keywords: Mono-, di-, and trinuclear tantalum and tantalum | niobium complexes with P4 and P2 ligands ; m̈-η2:1:1-P2 coordination mode ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Niobium and Tantalum Complexes with P2 and P4 LigandsThe photolysis of [Cp″Ta(CO)4] 1 (Cp″ = C5H3tBu2-1,3) and P4 affords Cp″(CO)2Ta(η4-P4) 2, [{Cp″(CO)Ta}2(m̈-η2:2-P2)2] 3 and [Cp3″(CO)3Ta3(P2)2] 4. In a photochemical reaction 2 and [Cp*Nb(CO)4] 5 form [{Cp*(CO)Nb}{Cp″(CO)Ta}(m̈-η2:2-P2)2] 6 and [{Cp*(CO)2Nb} {Cp*Nb}{Cp″(CO)Ta}(m̈3-η2:1:1-P2)2] 7, a compound with the novel m̈3-η2:2:1-P2-coordination mode. The reaction of 2 and [Cp*Co(C2H4)2] 8 leads to [{Cp*Co} {Cp″(CO)Ta}(m̈-η2:2-P2)2] 9, a heteronuclear complex with an „early“ and a „late“ transition metal. Complexes 2, 3, 7 and 9 have been further characterized by X-ray structure analyses.
    Notes: Die Photolyse von [Cp″Ta(CO)4] 1 (Cp″ = C5H3tBu2-1,3) und P4 ergibt [Cp″(CO)2Ta(η4-P4)] 2, [{Cp″(CO)Ta}2(μ-η2:2-P2)2] 3 und [Cp3″(CO)3Ta3(P2)2] 4. 2 reagiert photochemisch mit [Cp*Nb(CO)4] 5 zu [{Cp*(CO)Nb}{Cp″(CO)Ta}(m̈-η2:2-P2)2] 6 und [{Cp*(CO)2Nb}{Cp*Nb} {Cp″(CO)Ta}(m̈3-η2:1:1-P2)2] 7, einer Verbindung mit der neuen m̈3-η2:2:1-P2-Koordinationsvariante. Die Reaktion von 2 und [Cp*Co(C2H4)2] 8 führt zum heteronuklearen Komplex [{Cp*Co} {Cp″(CO)Ta}(m̈-η2:2-P2)2] 9 mit einem „frühen“ und „späten“ Übergangsmetall. Die Komplexe 2, 3, 7 und 9 wurden zusätzlich durch eine Röntgenstrukturanalyse charakterisiert.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1238
    Keywords: Intensive care units ; Streptococcus ; Antibiotics ; Antibiotic resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective The effect of selective decontamination of the digestive tract (SDD) on Intensive Therapy Unit (ITU)-acquired enterococcal infection and colonization was studied. Changes in the predominant species isolated and resistance patterns to antimicrobial agents were also studied. Design Three groups were investigated: historical control (HC), contemporaneous control (CC) and patients receiving SDD (topical polymyxin, amphoterecin B and tobramycin throughout ITU stay with intravenous ceftazidime for the first 3 days only). Setting Adult general ITU with 7 beds. Patients Patients with a nasogastric tube in situ and who were likely to remain in ITU for 48 h or longer were recruited. Results Enterococcal infections occured in 3 of 84 HC patients and 2 of 91 CC patients. There were no unit-acquired enterococcal infections in the SDD group. There were 140 episodes of enterococcal colonization occurring in 112 patients, with significantly more in the SDD and CC groups (p〈0.05. There were no significant differences in antibiotic sensitivities between the three groups.Enterococcus faecalis was the most frequently isolated species. Conclusion SDD does not predispose to enterococcal infection but does encourage colonization in patients receiving the regimen and other patients in ITU at the same. There is a complex interaction of factors which influence faecal flora and the likelihood of patients becoming colonized or infected with enterococci.
    Type of Medium: Electronic Resource
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