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  • Chemistry  (1)
  • Ciclosporin  (1)
  • Evolution, Molecular Biology  (1)
  • 2015-2019  (1)
  • 1985-1989  (2)
  • 1
    ISSN: 1432-0584
    Keywords: Ciclosporin ; Graft-versus-host-disease ; Bone marrow transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between 1982 and 1986 51 patients were treated with ciclosporin a (CSA) to prevent graft versus host disease (GvHD) after bone marrow transplantation (BMT). Major side effects of the drug were tremor, hypertension, hepatotoxicity and nephrotoxicity. Acute GvHD 0° to II° occurred in 80% of our patients, and GvHD III° and IV° in 20% despite the use of CSA. Two to four days before the onset of GvHD, CSA serum levels were significantly lower on the average in patients who developed GvHD III° and IV° compared to the others. Our data indicate that plasma CSA concentrations higher than 250 ng/ml should be achieved to reduce the severity of GvHD after BMT.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Investigation on the Thermal Behaviour of NH4Al(SO4)2 · 12 H2OThe behaviour of NH4Al(SO4)2 · 12 H2O as to an application as a heat storage material is investigated by means of isothermal and dynamic thermal analysis. The occurence of a metastable modification in subcooled melts and the tendency to decomposition with formation of mixed crystals from an ammonium and oxonium alunite are of special importance to the use in latent heat storage units. Effective long-term nucleating agents are not known.The decomposition reactions proceeding in the application as a reaction heat storage material are studied under quasi-isothermal and quasi-isobaric conditions. The decomposition proceeds via the steps NH4Al(SO4)2 · 1.5 H2O, NH4Al(SO4)2, Al2(SO4)3 to the formation of γ-Al2O3. The found decomposition temperatures agree approximately with the temperatures calculated from thermodynamic data.
    Notes: Mit Hilfe von isothermen und dynamischen thermischen Analysenmethoden wird das Verhalten des NH4Al(SO4)2 · 12 H2O hinsichtlich einer Anwendung als Wärmespeichermaterial untersucht. Für einen Einsatz in Latentwärmespeichern sind das ausgeprägte Unterkühlungsverhalten, das Auftreten einer metastabilen Modifikation in unterkühlten Schmelzen und die Neigung zur Zersetzung unter Bildung von Mischkristallen aus Ammonium- und Oxoniumalunit von besonderer Bedeutung. Dauerhaft wirksame Keimbildner sind nicht bekannt.Die für eine Verwendung als Reaktionswärmespeichermaterial ablaufenden Zersetzungsvorgänge werden unter quasi-isothermen und quasi-isobaren Bedingungen studiert. Der Abbau läuft über die Schritte NH4Al(SO4)2 · 1,5 H2O, NH4Al(SO4)2, Al2(SO4)3 zu γ-Al2O3. Die gefundenen Zersetzungstemperaturen stimmen mit den aus thermodynamischen Daten Berechneten Temperaturen näherungsweise überein.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2018-05-25
    Description: Computations in the mammalian cortex are carried out by glutamatergic and -aminobutyric acid–releasing (GABAergic) neurons forming specialized circuits and areas. Here we asked how these neurons and areas evolved in amniotes. We built a gene expression atlas of the pallium of two reptilian species using large-scale single-cell messenger RNA sequencing. The transcriptomic signature of glutamatergic neurons in reptilian cortex suggests that mammalian neocortical layers are made of new cell types generated by diversification of ancestral gene-regulatory programs. By contrast, the diversity of reptilian cortical GABAergic neurons indicates that the interneuron classes known in mammals already existed in the common ancestor of all amniotes.
    Keywords: Evolution, Molecular Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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