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  • 1
    ISSN: 1432-2307
    Keywords: Osteosarcoma ; Chemotherapy ; Quantitative Caryometry ; Morphometry ; Tumour regression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A current strategy for osteosarcoma treatment is neo-adjuvant chemotherapy prior to the resection of the tumour. It appears that some tumours respond very well to the cytostatic therapy, while others show little or no effect. It is desirable to be able predict the response of the tumour before starting chemotherapy. 16 biopsy specimens from patients with osteosarcoma who had been treated according to the protocol of the study COSS-80 and COSS-82 were examined. 100 tumour cells from each biopsy have been measured by an electronic interactive image analysis system (IBAS II; Kontron/ ZEISS). After completion of chemotherapy en bloc resection of the tumour was performed. The entire surgical specimen was completely examined at two levels by means of undecalcified sections, and assigned a grade for the effect of chemotherapy analogous to the grading of Salzer-Kuntschik et al. (1983). The quantitative analysis of tumour cell nuclei revealed two different patterns of nuclear sizes, which were correlated significantly with the chemotherapy response (P〈0.002). Tumour cell nuclei of well responders were significantly larger and showed a greater variance in size (mean value 66 + 41 µm2), than those of poor responders (mean value 38 + 18 µm2). We conclude from our results that quantitative analysis and classification of nuclear size of osteosarcoma cells may be useful for predicting chemotherapy response in patients with osteosarcoma.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2161
    Keywords: Osteosarcoma ; Chemotherapy ; Plain film radiography ; Angiography ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The prognosis of osteosarcoma has improved significantly with recent advances in chemotherapy. Evaluation of the effect of chemotherapy is important for optimal timing of surgery, for selecting an alternative drug regimen in instances of poor response to chemotherapy and for testing combinations of new drugs. The purpose of this paper is to define the value of plain radiographs and angiography in assessing tumor response to chemotherapy. Studies were obtained before and after chemotherapy. The radiographic results were correlated with histologic evaluation of the resected specimen. Patients with less than 10% residual viable tumor in the resected bone were designated “responders” and patients with more than 10% of remaining viable tumor were “nonresponders”. Angiographic appearances correctly separated 15 patients with good response to chemotherapy from seven patients who were not responsive. Conversely, comparison of plain radiographs obtained before and after chemotherapy did not allow a reliable differentiation between patients with good, poor, or no response to chemotherapy. The current role of angiography in the management of patients with osteosarcoma is discussed. It is concluded that — in contrast to plain film radiography — angiography is an accurate method for assessing the response of osteosarcoma to chemotherapy.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1335
    Keywords: Osteosarcoma ; Chemotherapy ; Histologic grades of regression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The histologic grade of regression of 50 osteosarcomas after polychemotherapy — according to the protocol study, COSS 80 — was classified on a six-stage regression scale; 56% of all patients responded well to chemotherapy regression grades I, II, and III and no significant difference between BCD- and CPL-treated patients could be found. Tumors under 10 cm in length responded better to chemotherapy than those of greater length and there was a good correlation between the clinical estimation of tumor regression and progression and the histologic grade of regression.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1335
    Keywords: Osteosarcoma ; Chemotherapy ; Imprint cytology ; Tumor-regression ; Undecalcified sections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Forty-five osteosarcomas were investigated by special methods such as preparation of undecalcified bone tumor tissue, imprint cytology, histochemistry, and quantitative analysis. The morphological regression grades and their relation to chemotherapy are reported by Salzer-Kuntschik et al. (1983). The results presented demonstrate that smaller osteosarcomas respond more favorably than larger tumors. The function of bone-tumor cells, e.g., osteoid production, trabecular tumor bone formation, and mineralization, seems to be more important for the sensitivity to chemotherapy than the cell polymorphism. The estimation of bone-tumor morphology in at least two total areas of the bone tumor is essential in borderline cases (grade III/grade IV). Imprint cytology is very helpful for rapid estimation of the effect of therapy and the demonstration of cellular polymorphism. At the moment, we are not able to determine the effect of chemotherapy from the first biopsy before starting chemotherapy.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1435-2451
    Keywords: Small cell lung cancer ; Stage dependent surgery ; Chemotherapy ; Radiotherapy ; Kleinzelliges Bronchialcarcinom ; Stadiengerechte Chirurgie ; Chemotherapie ; Radiotherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In enger Kooperation von Chirurgen, Chemotherapeuten und Strahlentherapeuten wurde in den letzten 9 Jahren folgendes Therapiekonzept zur Behandlung des kleinzelligen Bronchialcarcinoms (limited disease) entwickelt. Stadium I, II: 1) Radikale Resektion. 2) Chemotherapie. 3) Cerebrale Bestrahlungsprophylaxe. 4) Lokale Radiotherapie. Stadium III: 1) Chemotherapie. 2) cerebrale Prophylaxe. 3) Radikale Operation im Ausmaß der ursprünglichen Tumorausdehnung. 4) Lokale Bestrahlung. Die bisherigen Ergebnisse bei 15 Patienten sind ermutigend.
    Notes: Summary As a result of strict cooperation between oncologists, surgeons and radiotherapists we developed a comprehensive combination therapy for small cell lung cancer (limited disease): Stage I, II: 1) radical tumour resection. 2) chemotherapy (Cohen). 3) cerebral radiation prophylaxis. 4) locoregional radiotherapy. Stage III: 1) Chemotherapy. 2) cerebral radiation prophylaxis. 3) lung resection in an extension required by the initial tumour. 4) radiotherapy (local). The preliminary results in 15 patients are encouraging.
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