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  • 1
    ISSN: 1432-072X
    Keywords: New nucleoside-peptide antibiotic ; Chitin biosynthesis ; Structure elucidation ; Mass spectrometry ; Streptomyces tendae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Der Streptomycet Tü 901, Streptomyces tendae, bildet ein antifungisch wirkendes Nukleosid-Antibioticum, Nikkomycin. Als Angriffsort kommt die Chitinsynthese in Frage. Mit Hilfe der Massenspektrometrie und des chemischen Abbaus konnten Uracil, eine Aminohexuronsäure und eine neue, einen Pyridinring enthaltende Aminosäure nachgewiesen werden.
    Notes: Abstract From the fermentation broth of Streptomyces tendae Tü 901 a substance was isolated, which inhibits the growth of several fungi. The new antibiotic affects the chitchin biosynthesis. Its structure was identified by mass spectrometry of the products obtained after chemical degradation. Nikkomycin is a nucleoside-peptide antibiotic consisting of uracil, an amino hexuronic acid and a new amino acid containing a pyridin ring.
    Type of Medium: Electronic Resource
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