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    Publication Date: 2013-03-16
    Description: A core feature of protective T cell responses to infection is the robust expansion and diversification of naive antigen-specific T cell populations into short-lived effector and long-lived memory subsets. By means of in vivo fate mapping, we found a striking variability of immune responses derived from individual CD8(+) T cells and show that robust acute and recall immunity requires the initial recruitment of multiple precursors. Unbiased mathematical modeling identifies the random integration of multiple differentiation and division events as the driving force behind this variability. Within this probabilistic framework, cell fate is specified along a linear developmental path that progresses from slowly proliferating long-lived to rapidly expanding short-lived subsets. These data provide insights into how complex biological systems implement stochastic processes to guarantee robust outcomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buchholz, Veit R -- Flossdorf, Michael -- Hensel, Inge -- Kretschmer, Lorenz -- Weissbrich, Bianca -- Graf, Patricia -- Verschoor, Admar -- Schiemann, Matthias -- Hofer, Thomas -- Busch, Dirk H -- New York, N.Y. -- Science. 2013 May 3;340(6132):630-5. doi: 10.1126/science.1235454. Epub 2013 Mar 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Munich 81675, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23493420" target="_blank"〉PubMed〈/a〉
    Keywords: Adoptive Transfer ; Animals ; CD8-Positive T-Lymphocytes/*immunology ; Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Clonal Selection, Antigen-Mediated ; Computer Simulation ; *Immunity, Cellular ; *Immunologic Memory ; Immunophenotyping ; Interferon-gamma/biosynthesis ; Interleukin-2/biosynthesis ; Listeria monocytogenes ; Listeriosis/*immunology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Models, Immunological ; Single-Cell Analysis ; Stochastic Processes ; T-Cell Antigen Receptor Specificity ; T-Lymphocyte Subsets/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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