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  • Animal model  (1)
  • Combined therapy  (1)
  • Springer  (2)
  • 1
    ISSN: 1434-4726
    Keywords: Interferon-γ ; Interferon-α ; OK-432 ; Head and neck cancer ; Combined therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Although the drug OK-432 can induce the release of γ-interferon (IFN-γ), the serum concentrations of IFN-γ produced are very low. We studied the effects of combining OK-432 with α-interferon (IFN-α) on the endogenous production of IFN and the postoperative courses of patients with oral cavity cancers. Forty patients operated on for head and neck cancers were studied. Each patient was given an injection of OK-432 1 week after surgery. Between 10 and 14 days later, a combination of OK-432 and IFN-α was given to assess the effects of the concomitant use of IFN-α on IFN production. In 18 of the 30 patients given a large dose of IFN-α (3 or 5×106 IU/ mg protein), IFN production induced by OK-432 was enhanced. A small dose of IFN-α (7×103 IU) did not enhance the action of OK-432. OK-432 also induced the release of both endogenous IFN-γ and IFN-α, and the production of both types of IFN was enhanced by the concomitant administration of parenteral IFN-α. Next, 50 patients operated on for oral cavity cancers were given OK-432 or a combination of OK-432 and IFN-α for 4 months, and their postoperative courses were followed for 2–5 years. The clinical courses were better in the combined therapy group than in the group given OK-432 alone.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1437-7799
    Keywords: Key words Adenine ; Animal model ; Chronic renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. A renal failure model prepared from rats fed on an adenine diet provides valuable information about the pathomechanism of various complications associated with a persistent uremic state. To establish an animal experimental model in which the animals survive in a persistent uremic state, it is essential to settle a point of no return, i.e., an irreversible point. We investigated an irreversible point using the rat renal failure model induced by adenine treatment. Methods. Rats were fed on a diet containing 0.75% adenine for 2, 4, or 6 weeks, and they were then fed an adenine-free diet for an additional 4 weeks to evaluate the degree of recovery from renal dysfunction. Results. The rats fed on the adenine diet for 2 weeks showed a decrease in mean serum creatinine(s-Cr) from 1.8 mg/dl before to 0.7 mg/dl after the observation period, with mild anemia. The rats fed on the adenine diet for 4 weeks showed persistent renal dysfunction. Although the mean s-Cr decreased from 2.7 to 2.0 mg/dl, it continued to be higher than the normal range, and the anemia worsened. In the rats fed on the adenine diet for 6 weeks, the mean s-Cr increased from 3.4 to 3.6 mg/dl. Hypoproteinemia was also observed and some animals died. Conclusion. Based on the above results, it was concluded that to prepare a model of chronic renal failure in rats compatible to chronic renal failure seen clinically, the administration of a 0.75% adenine diet for 4 weeks is most appropriate.
    Type of Medium: Electronic Resource
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