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  • 133-Xenon-clearance  (1)
  • B-lymphoblastoid cell line  (1)
  • Constitutional disorders  (1)
  • Springer  (3)
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  • Springer  (3)
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  • 1
    ISSN: 1432-0584
    Keywords: Chronic myelogenous leukemia ; Trisomy 8 ; Trisomy 8 mosaicism syndrome ; Constitutional disorders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 17-year-old woman was admitted for bone marrow transplantation with the diagnosis of atypical Philadelphia-negative chronic myelogenous leukemia (aCML), cytogenetically characterized by trisomy 8 as the sole chromosome aberration. A striking feature was a congenital opacity of the right cornea. Chromosomal analysis of skin fibroblasts were performed and revealed a mosaic for trisomy 8. Commonly, a distinct clinical picture leads to the diagnosis of trisomy 8 mosaicism syndrome (T8ms), but an extreme phenotypic variability has been observed. To our knowledge the development of an aCML in a patient with T8ms has not been reported. A review of the literature revealed that an association to other hematological disorders had been described in two cases. The question of whether our patient's aCML was a random event or not is discussed. The patient is now 24 months post transplant and shows no evidence of disease. Her Karnofsky score is 100%. We conclude that it might be worthwhile to look for an associated constitutional trisomy 8 mosaicism in all patients with trisomy 8 leukemia.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 52 (1974), S. 728-735 
    ISSN: 1432-1440
    Keywords: Muscle blood flow ; 133-Xenon-clearance ; exercise ; upper arm ; forearm ; thumb ; age ; sex ; Muskeldurchblutung ; Belastung ; 133-Xenon-Clearance ; Ober- und Unterarm ; Daumen ; Alter ; Geschlecht ; Seitenunterschiede
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 65 Personen ohne arterielle Zirkulationsstörungen wurde die Muskeldurchblutung der Arme mit der 133-Xenon Clearance in Ruhe, bei Belastung und während der anschließenden reaktiven Hyperämie bestimmt. Im Gesamtkollektiv und bei Männern fand sich mit zunehmendem Alter eine Durchblutungsabnahme. Signifikante Geschlechts-oder Seitenunterschiede waren dagegen nicht festzustellen. Die vergleichende Messung ergab am Oberarm eine signifikante höhere Durchblutung bei Belastung und während der anschließenden reaktiven Hyperämie, als am Unterarm. Die Werte am Unterarm und am Daumenballen unterschieden sich dagegen nicht signifikant.
    Notes: Summary Muscle blood flow (MBF) was determined by 133-Xenonclearance at rest, during exercise and subsequent reactive hyperemia in 65 persons free of vascular symptoms. MBF decreased significantly with increasing age in the whole group and in males. No significant differences were found between males and females, or between the right and the left side. MBF was significantly higher on the upper arm, than on the forearms whereas no differences existed between forearm and thumb.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-0778
    Keywords: hPRL ; B-lymphoblastoid cell line ; karyotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The IM-9-P cell line is a variant of the human B-lymphoblastoid cell line IM-9 which ectopically secretes prolactin (hPRL). The heterogeneous line IM-9-P and three sublines of clonal origin, two of them positive and one negative for PRL gene expression, were subjected to cytogenetic analysis and compared with the reference line IM-9 which showed a normal female diploid karyotype. G-banding revealed several rearrangements in the chromosomes. Nine altered chromosomes including one stable marker chromosome were common to all analysed karyotypes of IM-9-P cells and their clones. A second marker chromosome ‘mar2’ occurred only in the karyotypes of the hPRL producing clones, but not in the non-producing clone. None of the visible alterations involve chromosome 6 which carries the PRL gene in humans.
    Type of Medium: Electronic Resource
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