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  • 1
    ISSN: 1433-3023
    Keywords: Antibiotics ; Cystitis ; Urinary tract infections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An ecological approach to the pathogenesis of uncomplicated urinary tract infections allows awareness of the continual battle being waged in the vagina, urethra, and bladder between the bacterial invaders and the host defense mechanisms. Despite overwhelming odds, the bacteria must be able to persist, colonize, and finally adhere to these various battlefields on their ascent to the bladder itself. The large number of patients presenting to physician offices with acute simple cystitis attests to the fact that the bacteria occasionally win the battle of the bladder. An understanding of the pathophysiology of this constantly raging battle may help us modify our clinical approach to women with simple uncomplicated urinary tract infections.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-3023
    Keywords: Cystitis ; Interstitial ; Refractory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Interstitial cystitis is the most therapeutically frustrating condition of the urinary tract. The vast array of treatments available clearly indicates that none is particularly effective. As the majority of patients fail to experience a significant and prolonged response to standard treatments, new options are frequently being developed. These include the oral administration of cimetidine, the intravesical use of hyaluronic acid and BCG, and total cystectomy with the formation of a continent urinary diversion. Unfortunately, the acceptance of many new treatments is based on incomplete evaluation, and this has resulted in a confusing array of disparate alternatives. Effective and durable treatment will not be available until the nature of the disease is better understood and the mechanisms of action of current therapies are elucidated.
    Type of Medium: Electronic Resource
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