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  • DKFZ Publication Database  (2)
  • C-arm CT  (1)
  • DEEP VENOUS THROMBOSIS  (1)
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  • DKFZ Publication Database  (2)
  • 1
    Keywords: REPRODUCIBILITY ; COMPUTED-TOMOGRAPHY ; POSTMENOPAUSAL WOMEN ; MECHANICAL-PROPERTIES ; FUNDAMENTAL PRINCIPLES ; BONE-STRUCTURE ; C-arm CT ; DISTAL RADIUS ; FINITE-ELEMENT ; Flat-panel volume CT (fpVCT) ; FRACTURE RISK ; HYPOGONADAL MEN ; Multi-detector CT (MDCT) ; Trabecular structure
    Abstract: Purpose This paper assesses interscan, interreader, and intrareader variability of C-arm CT and compares it to that of flat-panel volume-CT (fpVCT) and high-definition multi-detector-CT (HD-MDCT). Methods Five cadaver knee specimens were imaged using C-arm-CT, fpVCT, and HD-MDCT. Apparent (app.) trabecular bone volume fraction (BV/TV), app. trabecular number (TbN), app. trabecular spacing (TbSp), and app. trabecular thickness (TbTh) of the proximal tibia were measured by three readers. Interreader, intrareader, and interscan variability for C-arm CT was expressed as coefficient of variation (CV), standard deviation (SD), and intraclass correlation coefficient (ICC). Results With the exception of app.TbSp (CV: 7.05-9.35%, SD: 0.06-0.09, ICC: 0.89-0.94), the variability of C-arm CT was low (CV: 2.41-6.43%, SD: 0.01-0.048, ICC: 0.65-0.98). Its interreader reliability (CV: 2.66-4.55%, SD: 0.01-0.03, ICC: 0.81-0.95) was comparable to that of HD-MDCT (CV: 2.41-4.08%, SD: 0.014-0.016, ICC: 0.95-0.96), and fpVCT (CV: 3.13-5.63%, SD: 0.009-0.036, ICC: 0.64-0.98) for all parameters except app.TbSp. Conclusions C-arm CT is a reliable method for assessing trabecular bone architectural parameters with the exception of app.TbSp due to spatial resolution limitation
    Type of Publication: Journal article published
    PubMed ID: 20658286
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  • 2
    Keywords: SOLITARY PULMONARY NODULES ; POSITRON-EMISSION-TOMOGRAPHY ; CANCER PATIENTS ; DEEP VENOUS THROMBOSIS ; QUANTITATIVE ASSESSMENT ; NONSMALL CELL LUNG ; F-18 FDG PET/CT ; NEEDLE-BIOPSY ; TC-99M-DEPREOTIDE SPECT ; PLEURAL RECURRENCE
    Abstract: More than one decade ago, introduction of integrated PET/CT scanners changed oncologic imaging and oncologic patient management profoundly. With these systems, the metabolic information acquired by PET can be anatomically localized even to small structures such as small primary tumors, lymph nodes, and soft tissue masses owing to the high-resolution multidetector CT scanners. This has made PET/CT a most reliable method for tumor detection, characterization, staging, and response monitoring. The importance of an integrated functional and morphologic approach to better understand the biology of oncologic disease and to improve therapy planning is underlined by the increasing number of PET/CT systems worldwide, leading to an increasing number of scientific publications in the field. The paradigmatic indication of integrated PET/CT is staging of patients with lung cancer, as PET/CT allows for precise pretherapeutic staging and also posttreatment restaging according to the TNM criteria. The growing numbers of targeted therapy strategies in the fields of surgery, chemotherapy, and radiation therapy, which are adapted to dedicated tumor stages, require the exact classifications of each patient's tumor stage. In this context, whole-body examinations using integrated 18F-FDG-PET/CT have been shown to reduce the side effects of futile invasive procedures and reduce additional costly staging procedures. In this review article, the diagnostic and therapeutic effects of PET/CT examinations are highlighted and compared with some competitive techniques such as scintigraphy, MRI, and, where possible, integrated PET/MRI.
    Type of Publication: Journal article published
    PubMed ID: 26050655
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