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  • DISEASE  (2)
  • Deactivation  (2)
  • Gas-solid chromatography  (2)
  • 1
    Keywords: CELLS ; tumor ; CELL ; Germany ; neoplasms ; imaging ; TOOL ; DISEASE ; DISEASES ; RESOLUTION ; SURGERY ; MECHANISM ; MARKER ; prognosis ; AUTOIMMUNE-DISEASE ; mechanisms ; T cell ; T cells ; T-CELL ; T-CELLS ; treatment ; MARKERS ; RESECTION ; LOCALIZATION ; HEAD ; ATROPHY ; FUTURE ; DIABETES-MELLITUS ; AUTOANTIBODIES ; autoimmune pancreatitis ; PRIMARY SCLEROSING CHOLANGITIS ; SJOGRENS-SYNDROME ; INFLAMMATORY-BOWEL-DISEASE ; FEATURES ; fibrosis ; INFILTRATION ; inflammatory bowel disease ; AUTOIMMUNE-DISEASES ; STENOSIS ; LEVEL ; pancreatic ; MASS ; autoimmune disease ; TOOLS ; DUCT ; serological ; Diabetes Mellitus ; surgical resection ; BOWEL ; EFFECTIVE STEROID-THERAPY ; ENTITY ; IgG4 ; pancreatic neoplasms ; pancreatic tumor ; PSEUDOTUMOROUS PANCREATITIS ; SERUM IGG4 ; steroids ; URSODEOXYCHOLIC ACID
    Abstract: The term autoimmune pancreatitis (AIP) describes a nonalcoholic, chronic lymphoplasmocytic pancreatitis. The lymphoplasmocytic infiltration is characterized by periductal localization of predominantly CD4-positive T cells, fibrosis, and acinar atrophy, frequently resulting in stenosis of the main pancreatic and distal common bile ducts. Imaging studies often reveal a diffuse narrowing of the pancreatic main duct and swelling of the pancreatic head wrongly suggesting the presence of a malignant tumor. Clinical signs include mild abdominal pain,jaundice, recurrent episodes of acute pancreatitis, and even new-onset diabetes mellitus. Additionally, AIP can be associated with other autoimmune diseases such as Sjogren's syndrome, primary sclerosing cholangitis, chronic inflammatory bowel diseases, and retroperitoneal fibrosis. Serological markers include autoantibodies and increased levels of gamma globulin and especially IgG4. Steroids seem to be effective in improving clinical symptoms as well as in the resolution of pancreatic and bile duct narrowing. This distinguishes AIP from other forms of pancreatitis and from pancreatic neoplasms. Further studies of the underlying pathophysiologic mechanisms, prognosis, and new diagnostic tools are needed to provide adequate and effective treatment in the future. In this article, we summarize the current knowledge about AIP and present 17 cases that underwent surgical resection at our institution from 2003 to 2004
    Type of Publication: Journal article published
    PubMed ID: 17007063
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  • 2
    Keywords: Germany ; human ; DISEASE ; DISEASES ; PROTEIN ; MICE ; PATIENT ; ACID ; HUMANS ; mass spectrometry ; tandem mass spectrometry ; TANDEM MASS-SPECTROMETRY ; PATHOGENESIS ; MASS-SPECTROMETRY ; STRATEGIES ; RANDOMIZED-TRIAL ; ULCERATIVE-COLITIS ; CROHNS-DISEASE ; rodent ; INFLAMMATORY-BOWEL-DISEASE ; COLITIS ; GASTRIC-MUCOSA ; GASTRODUODENAL MUCOSAL PROTECTION ; inflammatory bowel disease ; phosphatidylcholine ; SPHINGOMYELIN ; USA ; ACID-RESIDUES ; NOV ; lipid ; PULMONARY SURFACTANT ; therapeutic ; STRATEGY ; INVESTIGATE ; CD ; COLONIC-MUCOSA ; EXTRACTS ; G-Protein ; GASTROINTESTINAL MUCUS ; lysophosphatidylcholine ; nano ESI mass spectrometry
    Abstract: Background: Phospholipids are essential for the normal function of the intestinal mucus barrier. The objective of this study was to systematically investigate phospholipids in the intestinal mucus of humans Suffering from inflammatory bowel diseases, where it barrier defect is strongly supposed to be pathogenetic. Methods: Optimal mucus recovery was first validated in healthy mice and the method was then transferred to the endoscopic acquisition of ileal and colonic mucus from 21 patients with ulcerative colitis (UC), 10 patients with Crohn's disease (CD), and 29 healthy controls. Nano-electrospray ionization tandem mass spectrometry (ESI-MS/MS) was used to determine phosphatidylcholine (PC), lysophosphatidylcholine (LPC), and sphingomyelin (SM) in lipid extracts of mucus specimens. Results: Human and rodent mucus contained very similar phospholipid species. In the ileal and colonic mucus from patients suffering from UC, the concentration of PC was highly significantly lower (607 +/- 147 pmol/100 mu g protein and 745 +/- 148 pmol/100 mu g protein) compared to that of patients with CD (3223 +/- 1519 pmol/100 mu g protein and 2450 +/- 431 pmol/100 mu g protein) and to controls (3870 +/- 760 pmol/100 mu g protein and 2790 +/- 354 pmol/100 mu g protein), overall, P = 0.0002 for ileal specimens and P 〈 0.0001 tor colonic specimens. Independent of disease activity, patients suffering from UC showed an increased Saturation grade of PC fatty acid residues and it higher LPC-to-PC ratio. Conclusions: The intestinal mucus barrier of patients with UC is significantly altered concerning its phospholipid concentration and species composition. These alterations may be very important for the pathogenesis of this disease and underline new therapeutic strategies
    Type of Publication: Journal article published
    PubMed ID: 19504612
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  • 3
    ISSN: 1612-1112
    Keywords: Gas-liquid chromatography ; Gas-solid chromatography ; Retention index data ; Cycloalkanes ; Cycloalkenes ; Cycloalkadienes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The retention indices of cycloalkenes and cycloalkadienes with C6–C13 rings are determined by gas-liquid chromatography (GLC) on glass capillary columns coated with OV-1 and Ucon LB 550X and by gas-solid chromatography (GSC) on a microcolumn packed with uncoated graphitized thermal carbon black (GTCB). Structure — retention correlations are derived on using index differences such as HOV, HGTCB and ΔI values, considering the differences in the stereochemistry of these compounds. It is shown that the combined application of index increments obtained in GLC and GSC provides more detailed structure informations. The value of the retention index units agree with the most stable conformations of the alicyclic compounds. The high value for the energy equivalent to an index unit (ΔGI.U.=4.18kJ/mol) confirmes that graphitized thermal carbon black causes much stronger dispersive interactions than any nonpolar liquid phase.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1612-1112
    Keywords: Gas-solid chromatography ; Graphitized thermal carbon black ; Hydrocarbon analysis ; Micropacked columns ; Separation of structural and spatial isomers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The adsorption of moelcules on the nonspecific and nonporous adsorbent graphitized thermal carbon black (GTCB) is mainly determined by their intermolecular dispersion interaction with the flat graphite surface. Since the retention values strongly depend on the geometrical configuration and shape of the investigated molecules and their arrangement on the graphite plane, it is possible to separate compounds with only small differences in their molecular shape on short columns packed with particles of pure or modified GTCB. The outstanding shape-selectivity of GTCB toward isomeric hydrocarbons is demonstrated by some examples. In most cases the elution sequences of isomeric compounds differ from that obtained in GLC using nonpolar stationary liquids. Moreover, the well defined relationship between retention data and molecular structure by adsorption on a flat and homogeneous surface give useful information for the identification of separated compounds or for the investigation of the molecular structure.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    ISSN: 0935-6304
    Keywords: Deactivation ; Capillary columns ; Silylation ; HPLC-silica ; Surface group concentration ; Pore alterations ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: High-temperature silylation (HTS) used for the deactivation of capillary columns was studied on the silica commonly used in HPLC to gain a better insight into this process. LiChrosorb Si 100 was silylated with disilazanes at different temperatures and the materials obtained were compared in terms of organic and silanol group surface concentration, IR reflection spectra, HPLC behavior, and pore distribution parameters. Applying diphenyltetramethyldisilazane, the volatile reaction products were monitored during the HTS process. With increasing silylation temperature up to 400°C the silanol surface concentration is reduced to a very small level independent of the organic group concentration which exhibits a broad maximum depending upon substituents and temperature. Up to 350°C triorganosiloxy groups prevail as bonded organic groups. It could be proved that HTS is accompanied by pore alterations of the silica matrix. Arguments proposed by different authors in explaining HTS effects are discussed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0935-6304
    Keywords: Gas chromatography, GC ; Capillary columns ; Deactivation ; High-temperature silylation ; Disilazanes ; Cyclosiloxanes ; Polysiloxanes ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: This retrospective article describes the beginnings and the development of silylation methods with diverse silazanes and siloxanes at high temperatures, and stresses their role in producing modern capillary columns characterized by a high degree of thermostability and adsorptive and catalytic inertness. Particular emphasis is placed on the outstanding contributions to this field of Kurt Grob, whose persilylation techniques provided the basis for the expansion of high resolution capillary gas chromatography.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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