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  • 1
    Keywords: RECEPTOR ; tumor ; carcinoma ; CELL ; Germany ; LUNG ; THERAPY ; CT ; DIAGNOSIS ; LUNG-CANCER ; DISEASE ; HISTORY ; liver ; PATIENT ; primary ; prognosis ; tumour ; LYMPH-NODES ; 5-FLUOROURACIL ; NO ; NEOPLASIA ; MALIGNANCIES ; METASTASIS ; metastases ; chemotherapy ; INVOLVEMENT ; SCINTIGRAPHY ; LIVER METASTASES ; SOMATOSTATIN ; POOR-PROGNOSIS ; pancreatic carcinoma ; ETOPOSIDE ; CELL CARCINOMA ; MALIGNANCY ; ENDOCRINE ; EXTRAPULMONARY ; GEMCITABINE ; NODES ; OF-THE-LITERATURE ; pancreas ; review ; small cell carcinoma ; somatostatin-analogue ; UNDIFFERENTIATED CARCINOMA
    Abstract: Small cell carcinoma (SCC) of the pancreas is a rare malignancy with an extremely poor prognosis. We present the case of a 74-year-old man with a 2-month history of upper abdominal discomfort who was diagnosed with SCC of the pancreas tail, involvement of peripancreatic and mesenteric lymph nodes and multiple liver metastases ( extended disease). A CT scan and a positive somatostatin receptor scintigraphy showed no evidence of a primary lung tumour. The diagnosis of a SCC was confirmed by biopsy. Local tumour control could be achieved by gemcitabine once a week and a long-acting somatostatin analogue once a month, but liver metastasis showed progress. Thus, 5-fluorouracil on a weekly basis was started. The patient died 8 months after diagnosis and had not been hospitalised in the meantime. Copyright (C) 2004 S. Karger AG, Basel and IAP
    Type of Publication: Journal article published
    PubMed ID: 15334003
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  • 2
    Keywords: Germany ; CLASSIFICATION ; DISEASE ; liver ; RISK ; GENE ; METABOLISM ; ACCUMULATION ; PATIENT ; FREQUENCY ; polymorphism ; SUSCEPTIBILITY ; VARIANTS ; FREQUENCIES ; NO ; DIFFERENCE ; genetics ; HETEROZYGOSITY ; PATHOGENESIS ; GENOTYPES ; HEREDITARY ; LENGTH ; adenocarcinoma ; pathology ; DIABETES-MELLITUS ; PREVALENCE ; heredity ; chronic pancreatitis ; MELLITUS ; pancreas ; VARIANT ; INCREASE ; PANCREATITIS ; HEREDITARY HEMOCHROMATOSIS ; IRON ; analysis ; methods ; pancreatic ; pancreatic adenocarcinoma ; GENOTYPE ; USA ; RISK-FACTOR ; FRAGMENT ; Diabetes Mellitus ; genetic analysis ; CHRONIC-PANCREATITIS ; acute pancreatitis ; ALCOHOLIC LIVER-DISEASE ; C282Y ; CYS282TYR MUTATION ; CYSTIC-FIBROSIS GENE ; H63D MUTATIONS ; hemochromatosis ; HFE ; IRON-OVERLOAD ; melting ; NONALCOHOLIC STEATOHEPATITIS
    Abstract: Purpose: The homozygous p.C282Y variant of the HFE gene is a major risk factor for hereditary hemochromatosis, a disorder of iron metabolism resulting in progressive iron accumulation in a variety of organs including the pancreas. Heterozygosity of p.C282Y and p.H63D may increase susceptibility to chronic liver and pancreatic disease. This study determines the frequencies of p.C282Y and p.H63D alterations in patients with chronic pancreatitis and pancreatic adenocarcinoma. Methods: In total, 958 patients (349 with alcoholic pancreatitis, 343 with idiopathic pancreatitis, 64 with familial chronic pancreatitis, 34 with acute pancreatitis, and 168 with pancreatic adenocarcinoma) were enrolled and compared with 681 healthy and 100 alcoholic controls. Furthermore, 45 parent-offspring trios were included for segregation analysis. Genotyping of p.C282Y and p.H63D was performed by restriction fragment length polymorphism or melting curve analyses. Results: No significant differences were found in heterozygosity for p.C282Y and p.H63D when patients with alcoholic (8.0/21.5%), idiopathic (7.3/24.5%), or familial (9.8/ 23.0%) pancreatitis, or pancreatic adenocarcinoma (5.4/28.6%) were compared with healthy (6.2/24.8%) and alcoholic (7.0/25.0%) controls. Neither genotype was associated with the presence of secondary diabetes mellitus in patients with chronic pancreatitis. Conclusion: Although hemochromatosis is associated with pancreatic pathology, the p.C282Y and p.H63D variants do not play a significant role in the pathogenesis of chronic pancreatitis or pancreatic adenocarcinoma
    Type of Publication: Journal article published
    PubMed ID: 17666895
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  • 3
    Keywords: COMBINATION ; evaluation ; Germany ; VOLUME ; DISEASE ; TIME ; PATIENT ; IMPACT ; QUALITY ; NO ; FEASIBILITY ; prospective studies ; small bowel ; methods ; capsule endoscopy ; YIELD ; prospective ; prospective study ; PEOPLE ; WORLD ; China ; DOUBLE-BALLOON ENTEROSCOPY ; ELECTROLYTE ; laxative ; preparation ; PULL ENTEROSCOPY ; TRANSIT ; transit time ; visibility
    Abstract: AIM: To determine the effect of Prepacol (R), a combination of sodium phosphate and bisacodyl, on transit and quality of capsule endoscopy (CE). METHODS: Fivety two consecutive patients were included in this prospective study. CE was performed following a 12 h fasting period. Twenty six patients were randomized for additional preparation with Prepacol. The quality of CE was assessed separately for the proximal and the distal small bowel by 3 experienced endoscopists on the basis of a graduation which was initially developed with 20 previous CE. RESULTS: Preparation with Prepacol (R) accelerated small bowel transit time (262 55 min vs 287 97 min), but had no effect on the quality of CE. Visibility was significantly reduced in the distal compared to the proximal small bowel. CONCLUSION: The significantly reduced visibility of CE in the distal small bowel allocates the need for a good preparation. Since Prepacol (R) has no beneficial effect on CE the modality of preparation and the ideal time of application remains unclear. Further standardized examinations are necessary to identify sufficient preparation procedures and to determine the impact of the volume of the preparation solution. (c) 2008 WJG. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 18395907
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