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  • DKFZ Publication Database  (2)
  • C-arm CT  (1)
  • DRUG  (1)
  • 1
    Abstract: Purpose This paper assesses interscan, interreader, and intrareader variability of C-arm CT and compares it to that of flat-panel volume-CT (fpVCT) and high-definition multi-detector-CT (HD-MDCT). Methods Five cadaver knee specimens were imaged using C-arm-CT, fpVCT, and HD-MDCT. Apparent (app.) trabecular bone volume fraction (BV/TV), app. trabecular number (TbN), app. trabecular spacing (TbSp), and app. trabecular thickness (TbTh) of the proximal tibia were measured by three readers. Interreader, intrareader, and interscan variability for C-arm CT was expressed as coefficient of variation (CV), standard deviation (SD), and intraclass correlation coefficient (ICC). Results With the exception of app.TbSp (CV: 7.05-9.35%, SD: 0.06-0.09, ICC: 0.89-0.94), the variability of C-arm CT was low (CV: 2.41-6.43%, SD: 0.01-0.048, ICC: 0.65-0.98). Its interreader reliability (CV: 2.66-4.55%, SD: 0.01-0.03, ICC: 0.81-0.95) was comparable to that of HD-MDCT (CV: 2.41-4.08%, SD: 0.014-0.016, ICC: 0.95-0.96), and fpVCT (CV: 3.13-5.63%, SD: 0.009-0.036, ICC: 0.64-0.98) for all parameters except app.TbSp. Conclusions C-arm CT is a reliable method for assessing trabecular bone architectural parameters with the exception of app.TbSp due to spatial resolution limitation
    Type of Publication: Journal article published
    PubMed ID: 20658286
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  • 2
    Keywords: IRRADIATION ; SURVIVAL ; Germany ; INHIBITION ; LUNG ; MODEL ; imaging ; EXPOSURE ; DRUG ; computed tomography ; MICE ; FAMILY ; REDUCTION ; MRI ; MAGNETIC-RESONANCE ; magnetic resonance imaging ; TARGET ; MOUSE ; radiosurgery ; resistance ; EXTRACELLULAR-MATRIX ; tomography ; COMPUTED-TOMOGRAPHY ; GROWTH-FACTOR-BETA ; inflammation ; INJURY ; FEATURES ; fibrosis ; ONCOLOGY ; MATRIX METALLOPROTEINASES ; DEFICIENT MICE ; SCIENCE ; KNOCKOUT MOUSE ; development ; ionizing radiation ; methods ; PHASE ; proteases ; matrix metalloproteinase ; INDUCED LUNG FIBROSIS ; outcome ; HEPATIC STELLATE CELLS ; PULMONARY FIBROSIS ; 13-DEFICIENT MICE ; MMP13 ; Volume computed tomography
    Abstract: Purpose: Pulmonary fibrosis is a disorder of the lungs with limited treatment options. Matrix metalloproteinases (MMPs) constitute a family of proteases that degrade extracellular matrix with roles in fibrosis. Here we studied the role of MMPI 3 in a radiation-induced lung fibrosis model using a MMP13 knockout mouse. Methods and Materials: We investigated the role of MMP13 in lung fibrosis by investigating the effects of MMP13 deficiency in C57BI/6 mice after 20-Gy thoracic irradiation (6-MV Linac). The morphologic results in histology were correlated with qualitative and quantitative results of volume computed tomography (VCT), magnetic resonance imaging (MRI), and clinical outcome. Results: We found that MMP13 deficient mice developed less pulmonary fibrosis than their wildtype counterparts, showed attenuated acute pulmonary inflammation (days after irradiation), and a reduction of inflammation during the later fibrogenic phase (5-6 months after irradiation). The reduced fibrosis in MMP13 deficient mice was evident in histology with reduced thickening of alveolar septi and reduced remodeling of the lung architecture in good correlation with reduced features of lung fibrosis in qualitative and quantitative VCT and MRI studies. The partial resistance of MMP13-deficient mice to fibrosis was associated with a tendency towards a prolonged mouse survival. Conclusions: Our data indicate that MMP13 has a role in the development of radiation-induced pulmonary fibrosis. Further, our findings suggest that MMP13 constitutes a potential drug target to attenuate radiation-induced lung fibrosis. (C) 2010 Elsevier Inc
    Type of Publication: Journal article published
    PubMed ID: 20457355
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