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  • Autoradiography  (1)
  • Benign osteochondromas  (1)
  • Drosophila persimilis  (1)
  • 1975-1979  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 132 (1979), S. 271-276 
    ISSN: 1432-1076
    Keywords: Exostoses ; Benign osteochondromas ; Bone tumors ; Radiation therapy ; Radium-224 ; Thorium X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Exostoses are benign cartilaginous tumors of bone. They can occur naturally or be induced by radiation therapy during the time of skeletal growth. We have observed exostoses in 28 of 218 children given repeated injections of radioactive bone-seeking 224Ra. The younger the age at irradiation, the higher the incidence of exostoses. Boys are more susceptible than girls. To our knowledge, none of these radiation-induced exostoses have become malignant, although 36 of these children have developed bone sarcomas elsewhere in the skeleton.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-3297
    Keywords: mating activity ; Drosophila persimilis ; chromosomal variants ; homokaryotypes ; heterosis for mating activity ; populational variation in mating activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Previous tests for mating activity ofDrosophila persimilis homokaryotype KL (Klamath) and MD (Mendocino) chromosomal arrangements (northern California population: Redwoods) had shown KL to mate faster on the average than MD in homogamic tests. A strain (double-cross hybrid of four KL lines from the same population) with reliable high mating activity was developed for testing the sexes separately. Five pairs of KL-MD homokaryotype strains were chosen to be tested by the criterion that each pair had been derived from a separate wild KL/MD progenitor. Strains were crossed within arrangements in a diallelic design (20 inter- and five intrastrain crosses tested in 16 replicates per cross) to provide mating activity indices of four sets: KL females, KL males, MD females, MD males. Mating tests employed ten virgin experimental flies with ten tester (double-cross hybrid) flies of the opposite sex in 30-min observation periods. All flies were matured for 5 days at 25°C before testing. Among parental strains, females were consistently higher in mating activity than males for both KL and MD arrangements. Most interstrain hybrids were heterotic, with KL and MD females not significantly different. However, hybrid MD males displayed greatest variation and had lowest mating activity, while KL males were the least variable and highest in mating activity. With heterosis in the hybrids, there was no predictability (additivity) from performance of parental strains to hybrid offspring. Mating activities of the two sexes were uncorrelated, indicating either that the sexes have independent genetic systems controlling mating activity or that the expression of the same genetic system is influenced by sex. Since the hybrid males of the two karyotypes displayed different courtship activity while the females were at about an equal level of receptivity, intrasexual selection among males is likely to be important in nature.
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  • 3
    ISSN: 1432-1912
    Keywords: 14C-Toxiferine ; Nicotinic acetylcholine receptor ; Motor endplate ; Endplate potential ; Autoradiography ; Saturation of drug binding sites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. To study the quantitative correlation between the stabilizing effect of toxiferine on the postsynaptic membrane and the number of drug binding sites at the motor endplate, experiments were performed on isolated mouse hemidiaphragms using combined electrophysiological and autoradiographic techniques. 2. The membrane stabilizing effect of 14C-toxiferine was investigated over a wide range of concentrations, in order to obtain not only muscle paralysis but the complete abolition of the endplate response to nerve stimulation. 3. Motor endplate activity was recorded intracellularly. For each concentration of the drug the percentage of endplates reacting to nerve stimulation with action potentials (a.p.), or with subliminal endplate potentials (e.p.p.), or being completely blocked, was determined. The mean amplitude of the e.p.p.'s was also calculated. 4. Reduction of the e.p.p. to an undetectable level required a concentration of 14C-toxiferine about 3 times greater than that which induced complete paralysis. 5. Correlation of these data with autoradiographic measurements demonstrated that decreasing e.p.p. amplitude corresponded to increasing values for the number of drug binding sites per endplate. Saturation was reached by that concentration which completely blocked the postsynaptic sensitivity to ACh. 6. It is concluded that at this concentration all the specific drug binding sites are occupied.
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