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  • ASSOCIATION  (2)
  • EXPOSURE  (2)
  • 1
    Keywords: CANCER ; Germany ; COMMON ; POPULATION ; RISK ; GENE ; SAMPLE ; PATIENT ; SKIN ; SEQUENCE ; ASSOCIATION ; polymorphism ; POLYMORPHISMS ; single nucleotide polymorphism ; BREAST-CANCER ; NO ; MUTATION ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; MELANOMA ; PATHOGENESIS ; REGION ; MALIGNANT-MELANOMA ; MELANOMA PATIENTS ; malignant melanoma ; SUSCEPTIBILITY GENE ; SINGLE ; molecular ; ONCOLOGY ; ASSOCIATIONS ; RE ; SINGLE NUCLEOTIDE POLYMORPHISMS ; analysis ; HAPLOTYPE ; HAPLOTYPES ; single-nucleotide ; PREDISPOSITION ; USA ; VITAMIN-D-RECEPTOR ; MEDICINE ; case control ; German ; case-control ; association study ; genetic analysis ; DNA-DAMAGE RESPONSE ; GERMLINE 657DEL5 MUTATION ; NBS1 ; NIJMEGEN-BREAKAGE-SYNDROME
    Abstract: The aim of this study was to investigate the role of NBS1 in the pathogenesis of malignant melanoma of the skin. To exclude the common 657del5 founder mutation, a total of 376 melanoma patients from Southern Germany were analyzed for sequence alterations in exon 6 of NBS1 by direct sequencing. Analyses revealed one 657del5 mutation and three nonsynonymous sequence variations in exon 6 of NBS1 (V210F, R215W, and F222L). Analysis of an additional sample of 629 melanoma patients and 604 controls revealed no F222L mutation, indicating that this newly identified sequence alteration is not a common polymorphism. In a case-control association study including 632 melanoma patients and 615 cancer-free control participants from Southern Germany, three publicly known single nucleotide polymorphisms located in the NBS1 gene region were analyzed. No significant associations between single nucleotide polymorphisms (rs9995, rs867185 and rs1063045) or referring calculated haplotypes and melanoma risk were identified. These results suggest that NBS1 does not play a major role in predisposition to melanoma in the Southern German population but that alterations of this gene might contribute to the risk of this cancer
    Type of Publication: Journal article published
    PubMed ID: 17496786
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  • 2
    Keywords: EXPOSURE ; RISK ; MAGNETIC-RESONANCE ; magnetic resonance imaging ; meta-analysis ; METAANALYSIS ; 8 TESLA ; high static magnetic fields ; MRI safety ; neurocognitive function
    Abstract: To evaluate whether cognitive processes, sensory perception, and vital signs might be influenced by static magnetic fields in magnetic resonance imaging (MRI), which could pose a risk for health personnel and patients, we conducted a meta-analysis of studies that examined effects of static magnetic fields. Studies covering the time from 1992 to 2007 were selected. Cohen's d effects sizes were used and combined in different categories of neuropsychology (reaction time, visual processing, eye-hand coordination, and working memory). Additionally, effects of static magnetic fields on sensory perception and vital signs were analyzed. In the category "neuropsychology," only effects on the visual system were homogeneous, showing a statistically significant impairment as a result of exposure to static magnetic fields (d = -0.415). Vital signs were not affected and effects on sensory perceptions included an increase of dizziness and vertigo, primarily caused by movement during static magnetic field gradient exposures. The number of studies dealing with this topic is very small and the experimental set-up of some of the analyzed studies makes it difficult to accurately determine the effects of static magnetic fields by themselves, excluding nonspecific factors. The implications of these results for MRI lead to suggestions for improvement in research designs
    Type of Publication: Journal article published
    PubMed ID: 21751291
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  • 3
    Keywords: SYSTEM ; EXPOSURE ; Cognition ; 8 TESLA ; CASE-CROSSOVER
    Abstract: Increasing field strengths in MRI necessitate the examination of potential side effects. Previously reported results have been contradictory, possibly caused by imbalanced samples. We aimed to examine whether special groups of people are more prone to develop side effects that might have led to contradictory results in previous studies. We examined the occurrence of sensory side effects in static magnetic fields of MRI scanners of 1.5, 3, and 7 T and a mock scanner in 41 healthy participants. The contribution of field strength, sex, age, and attention to bodily processes, and stress hormone levels to the sensation of dizziness was examined in separate univariate analyses and in a joint analysis that included all variables. Field strength and sex were significant factors in the joint analysis (P=0.001), with women being more strongly affected than men by dizziness in higher static magnetic fields. This effect was not mediated by the other variables such as attention to bodily symptoms or stress hormones. Further research needs to elucidate the underlying factors of increased dizziness in women in static magnetic fields in MRI. We hypothesize that imbalanced samples of earlier studies might be one reason for previous contradictory results on the side effects of static magnetic fields.
    Type of Publication: Journal article published
    PubMed ID: 25089803
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  • 4
    Keywords: CANCER ; tumor ; Germany ; RISK ; GENE ; PATIENT ; IMPACT ; ASSOCIATION ; polymorphism ; VARIANTS ; BREAST ; breast cancer ; BREAST-CANCER ; MELANOMA ; TUMOR-SUPPRESSOR GENE ; cancer risk ; HIGH-RISK ; INDIVIDUALS ; familial cancer ; BREAST-CANCER RISK ; RE ; TUMOR-SUPPRESSOR ; VARIANT ; ENHANCEMENT ; tumor suppressor gene ; INCREASED RISK ; CANCER-RISK ; FAMILIAL BREAST ; familial breast cancer ; ARLTS1 ; multiple melanomas
    Abstract: Variants in the tumor suppressor gene ARLTS1 (ADP-ribosylation factor-like tumor-suppressor gene 1) have been shown to influence familial cancer risk. Both Cys148Arg and Trp149Stop were associated with an increased risk of familial or high-risk familial breast cancer, respectively. We studied the impact of these gene variants on melanoma risk, investigating 351 melanoma patients and 804 control subjects. While ARLTS1 Trp149Stop did not influence melanoma risk (OR = 0.83, 95% CI = 0.37-1.88, p = 0.65), Cys148Arg revealed a statistically significant association with an increased risk for heterozygous carriers (OR = 1.43, 95% CI = 1.05-1.95, p = 0.02). An additional risk enhancement, though statistically non-significant, was observed in individuals with multiple melanomas (OR = 2.33, 95 % CI = 0.87-6.26, p = 0.08). (c) 2006 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 16646072
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