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  • Equatorial electrojet  (1)
  • Experimental liver tumors  (1)
  • Genetics  (1)
  • Germ cell tumour  (1)
  • High-grade glioma  (1)
  • 1
    ISSN: 0992-7689
    Keywords: Equatorial electrojet ; Magnetosphere-ionosphere interactions ; Electric fields and currents ; Auroral ionosphere ; Ionospheric disturbances
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Geomagnetic storm-time variations often occur coherently at high latitude and the day-side dip equator where they affect the normal eastward Sq field. This paper presents an analysis of ground magnetic field and ionospheric electrodynamic data related to the geomagnetic storm which occured on 27 May 1993 during the International Equatorial Electrojet Year (IEEY) experiment. This storm-signature analysis on the auroral, mid-latitude and equatorial ground field and ionospheric electrodynamic data leads to the identification of a sensitive response of the equatorial electrojet (EEJ) to large-scale auroral return current: this response consists in a change of the eastward electric field during the pre-sunrise hours (0400–0600 UT) coherently to the high-, mid-, and equatorial-latitude H decrease and the disappearance of the EEJ irregularities between the time-interval 0800–0950 UT. Subsequent to the change in h’F during pre-sunrise hours, the observed foF2 increase revealed an enhancement of the equatorial ionization anomaly (EIA) caused by the high-latitude penetrating electric field. The strengthening of these irregularities attested by the Doppler frequency increase tracks the H component at the equator which undergoes a rapid increase around 0800 UT. The ΔH variations observed at the equator are the sum of the following components: SR, DP, DR, DCF and DT.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0749-503X
    Keywords: Saccharomyces cerevisiae ; chromosome IV ; POL3 (CDC2) ; KIN28 ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The nucleotide sequence of a 5 kb EcoRI-NcoI fragment of chromosome IV, contiguous to gene POL3 (CDC2), has been determined. It contains three open reading frames: QRI1, QRI2 and QRI7. Two of them are essential genes. QRI7 is homologous to the Escherichia coli orfx gene. Accession number to EMBL/Genbank Data Library is X79380.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0843
    Keywords: Key words Mitoxantrone ; Intratumoral injections ; Experimental liver tumors ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The intratumoral (i.t.) delivery of anticancer drugs aims at controlling tumor growth and thereby provides palliative treatment for liver neoplasms. Mitoxantrone is a good candidate for local or regional administration because (1) its metabolism is mainly hepatic, (2) it has a steep dose-response curve for multiple solid tumors, and (3) its fixation in tissues is sustained without vesicant effects after extravasation. We compared the tolerance, pharmacokinetics, and antitumor effects of mitoxantrone on hepatic VX2 tumors in rabbits treated with i.t. intraarterial hepatic (i.a.h.) or i.v. mitoxantrone, i.t. ethanol; or i.t. 0.9% NaCl and in control animals. Tumor growth rates (TGRs) were evaluated at 9 days after treatment. Myelosuppression was the limiting toxicity of i.v. mitoxantrone at 1.5 mg/kg (maximal tolerated dose, MTD), but neither i.t. nor i.a.h. administration led to hematologic toxicity at the same dose. The mitoxantrone retained in tumors after i.t. administration was seen as blue-stained areas of complete necrosis according to histologic analysis. Pharmacokinetic parameters showed a significantly decreased systemic exposure to the drug after both regional treatments, although the i.a.h. route appeared to have an edge over the i.t. route. TGRs were significantly reduced after i.t. mitoxantrone (81±62%), i.a.h. mitoxantrone (337±110%), and i.t. ethanol treatments (287±117%) as compared with control values (886±223%; p〈0.01). Treatment with i.v. mitoxantrone (816±132%) had no antitumor effect, nor did NaCl injections (868±116%). Mitoxantrone given i.t. induced the highest antitumor effects, resulting in a 3.5-fold reduction in TGRs as compared with i.a.h. mitoxantrone and i.t. ethanol treatments (p〈0.02). Treatment with i.t. mitoxantrone provided efficient antitumor therapy without producing major side effects. This method should be considered as palliative treatment for nonresectable liver tumors and other localized malignancies.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1433-0350
    Keywords: Key words Medulloblastoma ; Primitive neuroectodermal tumour ; Germ cell tumour ; High-grade glioma ; Ependymoma ; Stem cell transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  New therapeutic strategies are required to improve the prognosis of malignant brain tumours in children, in terms of survival and quality of life. During the last 10 years, high-dose chemotherapy (HDCT) with autologous haematopoietic stem cell rescue has been studied in different types of paediatric brain tumours. The most frequently used combined regimens were busulfan-thiotepa and etoposide-thiotepa along with carboplatin or BCNU. High response rates have been reported in medulloblastoma and germ cell tumours, and HDCT has been further developed as salvage therapy or for consolidation in these diseases. Interesting objective tumour responses have been obtained in supratentorial high-grade glioma, but HDCT has not so far been effective either in ependymoma or in diffuse pontine brain stem tumours. This article reviews the rationale for HDCT in brain tumours and the current clinical results obtained in each tumour type. The place of HDCT in the therapeutic strategy for paediatric brain tumours, especially in young children, is discussed.
    Type of Medium: Electronic Resource
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