Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • (M. sexta)  (1)
  • Exposure test  (1)
  • High performance gas chromatography  (1)
  • 1
    ISSN: 1432-0738
    Keywords: Metabolites of toluene, xylene, styrene ; Benzoic, 3-and 4-methyl-benzoic acids ; Mandelic acid ; High performance gas chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der Arbeit wird die Gesamtbestimmung von Benzoesäure, 3-und 4-Methylbenzoesäure sowie Mandelsäure im Harn mit der Gaschromatographie (G.C.) dargestellt. Das analytische Verfahren umfaßt die Addition des inneren Standards β-Naphthol zur Harnprobe, die alkalische Hydrolyse, die Harnextraktion mit Äthyläther, das Lösungsmittelabdämpfen sowie die Silylierung der trockenen Rückstände (von Säuren) mit dem Gemisch Silyl-8-Pyridin (1 ∶ 1). Die Ergebnisse werden anhand der Relationen aus den Peakflächen der zu bestimmenden Metaboliten und dem inneren Standard (Standardabweichung) berechnet. Die Genauigkeit der erarbeiteten Methode beträgt bei der Bestimmung der genannten Säuren ±8%.
    Notes: Abstract The determination of benzoic, 3-and 4-methylbenzoic, and mandelic acids in urine by gas chromatography (G.C.) is presented. The analytical procedure includes: addition of internal standard (β-naphthol), alkaline hydrolysis, ethyl ether extraction, evaporation of the solvent, and silylation of acids with Silyl-8 in pyridine (1∶1). The results are calculated from ratios of the internal standard and determined metabolites peak surface areas. The coefficient of variation of the method in determination of mentioned acids is ±8%.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-1246
    Keywords: Styrene ; Mandelic acid ; Phenylglyoxylic acid ; Inhalation exposure ; Exposure test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Volunteers (six men and one woman) were exposed by inhalation to styrene within the concentration range of 20 to 200 mg/m3. The average retention of styrene vapours in the respiratory tract was 71%. The yield of styrene metabolism measured within 24 h was 39 and 17% for mandelic acid and phenylglyoxylic acid, respectively. The determination of mandelic acid in urine collected immediately after the exposure was applied as exposure test. The excretion rate of this metabolite assured the best correlation with the absorbed dose. The relative standard deviations of the test related to acutal dose level vary, depending on the analysed concentration range, from 0.21 to 0.33. Quantitative interpretation of the test is possible for styrene concentrations in the air exceeding 20 mg/m3. The concentration amounting to 100 mg/m3 (TI-V) corresponds with the mandelic acid excretion rate of 15 mg per hour.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 0005-2736
    Keywords: (M. sexta) ; ATPase, H^+- ; Insect midgut ; Vacuolar H^+-ATPase ; cDNA cloning
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...