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  • 1
    ISSN: 1432-069X
    Keywords: Kaposi's sarcoma ; Initial lesion ; HIV infection ; Spindle cells ; AIDS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Kaposi's sarcoma (KS) in human immunodeficiency virus infection (HIV) has become a rather frequent manifestation of the previously rare disease with fatal outcome. Initial lesions of KS were studied by means of histopathology, immunohistology, and electron microscopy in order to define the earliest alterations. The histopathological changes of initial lesions were distinct, consisting of (1) discrete proliferation of capillary vessels, (2) dissection of collagen by proliferating spindle cells which formed slits, (3) atypical spindle cells arranged in an Indian file pattern, and (4) the lack of any inflammatory cellular infiltrate. Double staining with antibodies against vimentin and immunohistochemical markers for endothelial cells revealed that slits forming vimentin-positive spindle cells displayed laminin, factor VIII, and PAL-E. Atypical vimentinpositive spindle cells arranged in an Indian file pattern inconsistently expressed laminin and factor VIII, but not PAL-E. KS cells rarely stained with the lectin UEA I, not even in case of less advanced dedifferentiation. Electron microscopy showed gradual transformation between spindle cells forming slits and those having lost the ability to form incomplete vessel walls. The present findings support the view that KS develops from the endothelial cells of the blood vessels. The proliferation of atypical endothelial cells as early as in initial lesions and the lack of inflammation favors the primary neoplastic genesis of KS.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-069X
    Keywords: Psoriasis ; Polymorphonuclear leukocytes ; Myeloperoxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The specific activity of myeloperoxidase (MPO), an enzyme located in the primary granules of polymorphonuclear leukocytes, was measured in patients with psoriasis vulgaris and compared with that in patients with atopic dermatitis and in healthy subjects. MPO catalyzes the oxidation of guaiacol into tetraguaiacol in the presence of H2O2. The activity was determined by photometric measurement of tetraguaiacol. The specific MPO activity showed no statistically significant difference between the healthy subjects and the patients with atopic dermatitis. In comparison to these two groups the specific MOP activity of the psoriatic patients showed a slight reduction which was, however, not statistically significant.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-069X
    Keywords: Histiocytoma ; Fibroma ; Sclerosing angioma ; Histiocytom ; Fibrom ; Sklerosierendes Angiom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Überprüft man in Histiocytomen mit Hilfe des Nachweises der alkalischen Phosphatase den Verlauf der Capillaren, so überrascht die große Zahl der Gefäße. Von einem Zentrum erstrecken sich diese durch das ganze Histiocytom, selbst die über dem Histiocytom unter der Epidermis gelegenen Capillaren sind gewuchert. Histochemische und elektronenmikroskopische Untersuchungen zeigen aber, daß die Mehrzahl der Tumorzellen keine Gefäßzellen sind, sondern Fibroblasten, Histiocyten und Mastzellen. Die jüngeren Fibroblasten gleichen Elementen, die man auch bei der Wundheilung findet und die man als C-Fibroblasten bezeichnet hat.
    Notes: Summary In histiocytomas the alkaline phosphatase technique reveals a surprising number of capillaries. The capillaries branch out from the center to the periphery of the histiocytoma and even the capillaries beneath the epidermis proliferate. The cellular elements outside the capillaries, however, are fibroblasts, histiocytes and mast cells, as is revealed by various histochemical and electron microscopical examinations. Histiocytomas of short duration differ from older histiocytomas in that the former contain fibroblasts similar to those found in healing wounds (C-fibroblasts).
    Type of Medium: Electronic Resource
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