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  • 1
    Keywords: CANCER ; human ; PATHWAY ; PATHWAYS ; DISEASE ; EPIDEMIOLOGY ; POPULATION ; RISK ; GENE ; GENES ; TUMOR-NECROSIS-FACTOR ; ASSOCIATION ; polymorphism ; SUSCEPTIBILITY ; LYMPHOMA ; case-control studies ; INDIVIDUALS ; ALCOHOL-CONSUMPTION ; B-CELL LYMPHOMA ; FACTOR-ALPHA ; CYTOKINE ; case-control study ; case control studies ; single-nucleotide ; single-nucleotide polymorphism ; GENOTYPE DATA ; pooled analysis ; INTERLEUKIN-10 ; PROMOTER POLYMORPHISMS ; BIOLOGICAL IMPLICATIONS
    Abstract: Background Common genetic variants in immune and inflammatory response genes can affect the risk of developing non-Hodgkin lymphoma. We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph). Methods We selected 12 single-nucleotide polymorphisms for analysis, on the basis of previous functional or association data, in nine genes that have important roles in lymphoid development, Th1/Th2 balance, and proinflammatory or anti-inflammatory pathways (IL1A, IL1RN, IL1B, IL2, IL6, IL10, TNF, LTA, and CARD15). Genotype data for one or more single-nucleotide polymorphisms were available for 3586 cases of non-Hodgkin lymphoma and for 4018 controls, and were assessed in a pooled analysis by use of a random-effects logistic regression model. Findings The tumour necrosis factor (TNF) -308G -〉 A polymorphism was associated with increased risk of nonHodgkin lymphoma (p for trend=0 . 005), particularly for diffuse large B-cell lymphoma, the main histological subtype (odds ratio 1 . 29 [95% CI 1 . 10-1 . 51] for GA and 1.65 [1 . 16-2 . 34] for AA, p for trend 〈 0 . 0001), but not for follicular lymphoma. The interleukin 10 (IL10) -3575T -〉 A polymorphism was also associated with increased risk of non-Hodgkin lymphoma (p for trend=0 . 02), again particularly for diffuse large B-cell lymphoma (p for trend=0 . 006). For individuals homozygous for the TNF -308A allele and carrying at least one IL 10 -3575A allele, risk of diffuse large B-cell lymphoma doubled (2 . 13 [1 . 37-3 . 32], p=0 . 00083). Interpretation Common polymorphisms in TNF and IL10, key cytokines for the inflammatory response and Th1/Th2 balance, could be susceptibility loci for non-Hodgkin lymphoma. Moreover, our results underscore the importance of consortia for investigating the genetic basis of chronic diseases like cancer
    Type of Publication: Journal article published
    PubMed ID: 16389181
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  • 2
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    Haematologica 92 (7), 960-969 
    Keywords: ENERGIES ; GROWTH ; SURVIVAL ; COMMON ; DISEASE ; POPULATION ; RISK ; GENE ; GENES ; METABOLISM ; MECHANISM ; GENETIC POLYMORPHISMS ; mechanisms ; ASSOCIATION ; polymorphism ; POLYMORPHISMS ; SUSCEPTIBILITY ; VARIANTS ; DELETION ; hormone ; LYMPHOMA ; ENERGY ; SNP ; NECROSIS-FACTOR-ALPHA ; POPULATIONS ; genetic polymorphism ; REPLICATION ; case-control studies ; ALCOHOL ; EPSTEIN-BARR-VIRUS ; FAMILY-CANCER DATABASE ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; B-CELL LYMPHOMA ; DNA-REPAIR GENES ; CROSS-TALK ; case control study ; case-control study ; NHL ; review ; ASSOCIATIONS ; VARIANT ; ALLELE ; PENETRANCE ; regulation ; non-Hodgkin lymphoma ; ALLELES ; case control studies ; USA ; GENETIC SUSCEPTIBILITY ; INCREASED RISK ; B-CELL ; NON-HODGKIN-LYMPHOMA ; case control ; hematology ; case-control ; GENETIC-SUSCEPTIBILITY ; FOLATE-METABOLIZING GENES ; OXIDATIVE STRESS GENES ; S-TRANSFERASE GENOTYPES
    Abstract: Genetic susceptibility studies of lymphoma may serve to identify at risk populations and clarify important disease mechanisms. This review considered all studies published through October 2006 on the contribution of genetic polymorphisms in the risk of lymphoma. Numerous studies implicate the role of genetic variants that promote B-cell survival and growth with increased risk of lymphoma. Several reports including a large pooled study by InterLymph, an international consortium of non-Hodgkin lymphoma (NHL) case-control studies, found positive associations between variant alleles in TNF -308G 〉 A and IL10 -3575T 〉 A genes and risk of diffuse large B-cell lymphoma. Four studies reported positive associations between a GSTT1 deletion and risk of Hodgkin and non-Hodgkin lymphoma. Genetic studies of folate-metabolizing genes implicate folate in NHL risk, but further studies that include folate and alcohol intakes are needed. Links between NHL and genes involved in energy regulation and hormone production and metabolism may provide insights into novel mechanisms implicating neuro- and endocrine-immune cross-talk with lymphomagenesis. However, this links will need replication in larger populations. Numerous studies suggest that common genetic variants with low penetrance influence lymphoma risk, though replication studies will be needed to eliminate false positive associations
    Type of Publication: Journal article published
    PubMed ID: 17606447
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  • 3
    Keywords: RISK ; GENE ; GENES ; ASSOCIATION ; polymorphism ; SUSCEPTIBILITY ; LYMPHOMA ; PROMOTER ; meta-analysis ; FOLLICULAR LYMPHOMA ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; VARIANT ; RHEUMATOID-ARTHRITIS ; ALLELES ; pooled analysis ; B-CELL ; SUBGROUPS ; INTERLEUKIN-10 ; SUN EXPOSURE ; GENETIC-VARIATION ; non-Hodgkin ; Genetic ; IMMUNE ; single nucleotide ; lymphotoxin-alpha ; tumor necrosis factor-alpha
    Abstract: In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants were added to previous data (patients diagnosed from 1989 to 2005 in 14 case-control studies; 7,999 cases, 8,452 controls) for testing of polymorphisms in the TNF -308G 〉 A (rs1800629), lymphotoxin-alpha (LTA) 252A 〉 G (rs909253), IL10 -3575T 〉 A (rs1800890, rs1800896), and nucleotide-binding oligomerization domain containing 2 (NOD2) 3020insC (rs2066847) genes. Odds ratios were estimated for non-Hispanic whites and several ethnic subgroups using 2-sided tests. Consistent with previous findings, odds ratios were increased for "new" participant TNF -308A carriers (NHL: per-allele odds ratio (ORallelic) = 1.10, P-trend = 0.001; diffuse large B-cell lymphoma (DLBCL): ORallelic = 1.23, P-trend = 0.004). In the combined population, odds ratios were increased for TNF -308A carriers (NHL: ORallelic = 1.13, P-trend = 0.0001; DLBCL: ORallelic = 1.25, P-trend = 3.7 x 10(-6); marginal zone lymphoma: ORallelic = 1.35, P-trend = 0.004) and LTA 252G carriers (DLBCL: ORallelic = 1.12, P-trend = 0.006; mycosis fungoides: ORallelic = 1.44, P-trend = 0.015). The LTA 252A 〉 G/TNF -308G 〉 A haplotype containing the LTA/TNF variant alleles was strongly associated with DLBCL (P = 2.9 x 10(-8)). Results suggested associations between IL10 -3575T 〉 A and DLBCL (P-trend = 0.02) and IL10 -1082A 〉 G and mantle cell lymphoma (P-trend = 0.04). These findings strengthen previous results for DLBCL and the LTA 252A 〉 G/TNF -308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology
    Type of Publication: Journal article published
    PubMed ID: 20047977
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