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  • Drittgradige Brandverletzung  (1)
  • Flüssigextraktion bzw. Direktmessung für Harn  (1)
  • GENOME-WIDE ASSOCIATION  (1)
  • Necrectomy
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  • 1
    Keywords: POLYMORPHISMS ; HEALTH ; BREAST-CANCER RISK ; POSTMENOPAUSAL WOMEN ; TAMOXIFEN ; ESTROGEN ; GENOME-WIDE ASSOCIATION ; PHOSPHOLIPASE C-GAMMA-2 ; SUSCEPTIBILITY VARIANTS ; PROLACTIN LEVELS
    Abstract: INTRODUCTION: Mammographic density is an established breast cancer risk factor with a strong genetic component and can be increased in women using menopausal hormone therapy (MHT). Here, we aimed to identify genetic variants that may modify the association between MHT use and mammographic density. METHODS: The study comprised 6,298 postmenopausal women from the Mayo Mammography Health Study and nine studies included in the Breast Cancer Association Consortium. We selected for evaluation 1327 single nucleotide polymorphisms (SNPs) showing the lowest P-values for interaction (P int) in a meta-analysis of genome-wide gene-environment interaction studies with MHT use on risk of breast cancer, 2541 SNPs in candidate genes (AKR1C4, CYP1A1-CYP1A2, CYP1B1, ESR2, PPARG, PRL, SULT1A1-SULT1A2 and TNF) and ten SNPs (AREG-rs10034692, PRDM6-rs186749, ESR1-rs12665607, ZNF365-rs10995190, 8p11.23-rs7816345, LSP1-rs3817198, IGF1-rs703556, 12q24-rs1265507, TMEM184B-rs7289126, and SGSM3-rs17001868) associated with mammographic density in genome-wide studies. We used multiple linear regression models adjusted for potential confounders to evaluate interactions between SNPs and current use of MHT on mammographic density. RESULTS: No significant interactions were identified after adjustment for multiple testing. The strongest SNP-MHT interaction (unadjusted P int 〈0.0004) was observed with rs9358531 6.5kb 5' of PRL. Furthermore, three SNPs in PLCG2 that had previously been shown to modify the association of MHT use with breast cancer risk were found to modify also the association of MHT use with mammographic density (unadjusted P int 〈0.002), but solely among cases (unadjusted P int SNPxMHTxcase-status 〈0.02). CONCLUSIONS: The study identified potential interactions on mammographic density between current use of MHT and SNPs near PRL and in PLCG2, which require confirmation. Given the moderate size of the interactions observed, larger studies are needed to identify genetic modifiers of the association of MHT use with mammographic density.
    Type of Publication: Journal article published
    PubMed ID: 26275715
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    ISSN: 1618-2650
    Keywords: Best. von Cadmium in Blut, Harn ; Spektralphotometrie, Atomabsorption ; elektrothermal, Deproteinierung/Matrixmodifikation für Vollblut ; Flüssigextraktion bzw. Direktmessung für Harn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary Simple, rapid methods are described for the determination of Cadmium in whole blood and urine by means of electrothermal atomic absorption spectrophotometry. 50–200 μl aliquots of whole blood were treated with 1M HNO3 for deproteinization and matrix modification. After centrifuging the supernatant is taken for automated electrothermal atomicabsorption spectrophotometry (ETAAS). Precision, expressed as day-to-day precision varied from 30% at 0.4 μg Cd/l to 3.8% at 9.3 μg Cd/l whole blood. If 25 μl of an 1+3 diluted blood are injected a detection limit of ≤ 0.2 μg Cd/l is achieved. Direct automated Cd-determinations in urine are feasible after dilution from about 0.2 μg Cd/l. Solvent extraction using NaDDC/MIBK is possible to ≤ 0.1 μg Cd/l. The day-to-day reproducibility varies from 26% at about 0.6 μg to 7.1% at about 27 μg Cd/l urine. The accuracy of these methods was checked by differential-pulse-anodic-stripping voltammetry (DPASV) and independent AAS procedures and found to be quite acceptable with an average total error of ≤ 30%. In routine up to 200 Cd measurements are possible in whole blood and up to 160 direct Cd measurements in urine per day (10 h).
    Notes: Zusammenfassung Einfache, rasche Methoden für die Bestimmung von Cadmium in Vollblut und Harn mit elektrothermaler Atomabsorptionsspektrometrie werden beschrieben. 50–200 μl Aliquots von Vollblut werden mit 1 M HNO3 zur Deproteinierung und Matrixmodifikation behandelt. Nach Zentrifugieren wird die überstehende Lösung zur automatisierten elektrothermalen Atomabsorptionsspektrophotometrie (ETAAS) verwendet. Die Reproduzierbarkeit, ausgedrückt als Tag-zu-Tag-Reproduzierbarkeit variert von 30% bei 0,4 μg Cd/l bis zu 3,8% bei 9,3 μg Cd/l Vollblut. Bei 25 μl-Eingabe eines 1+3 verdünnten Bluts wird eine Nachweisgrenze von ≤ 0,2 μg Cd/l erreicht. Direkte automatisierte Cd-Bestimmungen im Harn sind nach Verdünnung ab 0,2 μg Cd/l durchführbar. Flüssigextraktion mit NaDDC/MIBK erlaubt Cd-Bestimmungen bis ≤ 0,1μg Cd/l. Die Tag-zu-Tag-Reproduzierbarkeit variiert von 26% bei etwa 0,6 μg Cd/l bis 7,1% bei etwa 27 μg Cd/l Harn. Die Richtigkeit dieser Methoden wurde durch Differential — Pulse — Anodic — Stripping — Voltammetrie (DPASV) und unabhängige AAS-Verfahren überprüft und als akzeptabel mit einem mittleren Gesamtfehler von ≤ 30% gefunden. Im Routinebetrieb sind bis zu 200 Cd-Messungen in Blut und bis zu 160 Direkt-Messungen von Cd in Harn pro Arbeitstag (10 h) möglich.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 364 (1984), S. 229-232 
    ISSN: 1435-2451
    Keywords: Third-degree burn injuries ; Necrectomy ; Temporary defect cover ; Skin transplantation ; Drittgradige Brandverletzung ; Nekrektomie ; Temporäre Defektdeckung ; Hauttransplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Drittgradige Brandverletzungen erfordern aus vitaler, funktioneller oder ästhetischer Indikation eine plastisch-chirurgische Therapie. Um das Infektionsrisiko möglichst gering zu halten, sollte mit der Nekrektomie so früh als möglich begonnen werden. Ausdehnung und Tiefe der Gewebsschädigung, der Infektionsgrad der Wunde sowie der Allgemeinzustand des Verletzten entscheiden darüber, ob eine temporäre Defektdeckung notwendig ist oder die autologe Spalthauttransplantation sofort angeschlossen werden kann. Hierzu haben sich neben den Streifentransplantaten Mesh-graft-Transplantate in unterschiedlicher Vergrößerung sehr bewährt.
    Notes: Summary In third-degree bum injuries vital, functional or esthetic indications require surgical therapy. In order to keep the risk of infection as low as possible it is necessary to begin with the necrectomy as soon as possible. Extent and depth of the damaged tissue, the degree of the wound infection as well as the patient's physical condition decide whether the defect should be covered temporarily or whether an autologous splitskin transplantation should be performed. In addition to stripe transplants meshgraft-transplants of different sizes have proved to be very successful in surgery of burn injuries.
    Type of Medium: Electronic Resource
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