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  • Ciclosporin  (1)
  • GTPase-Activating Proteins/chemistry/genetics/*physiology  (1)
  • 2015-2019  (1)
  • 1985-1989  (1)
  • 2015-2019  (1)
  • 1985-1989  (1)
  • 1
    ISSN: 1432-0584
    Keywords: Ciclosporin ; Graft-versus-host-disease ; Bone marrow transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between 1982 and 1986 51 patients were treated with ciclosporin a (CSA) to prevent graft versus host disease (GvHD) after bone marrow transplantation (BMT). Major side effects of the drug were tremor, hypertension, hepatotoxicity and nephrotoxicity. Acute GvHD 0° to II° occurred in 80% of our patients, and GvHD III° and IV° in 20% despite the use of CSA. Two to four days before the onset of GvHD, CSA serum levels were significantly lower on the average in patients who developed GvHD III° and IV° compared to the others. Our data indicate that plasma CSA concentrations higher than 250 ng/ml should be achieved to reduce the severity of GvHD after BMT.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2015-02-28
    Description: Evolutionary expansion of the human neocortex reflects increased amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. In this work, we analyze the transcriptomes of distinct progenitor subpopulations isolated by a cell polarity-based approach from developing mouse and human neocortex. We identify 56 genes preferentially expressed in human apical and basal radial glia that lack mouse orthologs. Among these, ARHGAP11B has the highest degree of radial glia-specific expression. ARHGAP11B arose from partial duplication of ARHGAP11A (which encodes a Rho guanosine triphosphatase-activating protein) on the human lineage after separation from the chimpanzee lineage. Expression of ARHGAP11B in embryonic mouse neocortex promotes basal progenitor generation and self-renewal and can increase cortical plate area and induce gyrification. Hence, ARHGAP11B may have contributed to evolutionary expansion of human neocortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Florio, Marta -- Albert, Mareike -- Taverna, Elena -- Namba, Takashi -- Brandl, Holger -- Lewitus, Eric -- Haffner, Christiane -- Sykes, Alex -- Wong, Fong Kuan -- Peters, Jula -- Guhr, Elaine -- Klemroth, Sylvia -- Prufer, Kay -- Kelso, Janet -- Naumann, Ronald -- Nusslein, Ina -- Dahl, Andreas -- Lachmann, Robert -- Paabo, Svante -- Huttner, Wieland B -- New York, N.Y. -- Science. 2015 Mar 27;347(6229):1465-70. doi: 10.1126/science.aaa1975. Epub 2015 Feb 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Pfotenhauerstrasse 108, D-01307 Dresden, Germany. ; Technische Universitat Dresden, Center for Regenerative Therapies Dresden, Fetscherstrasse 105, D-01307 Dresden, Germany. ; Max Planck Institute for Evolutionary Anthropology (MPI-EVA), Deutscher Platz 6, D-04103 Leipzig, Germany. ; Technische Universitat Dresden, Universitatsklinikum Carl Gustav Carus, Klinik und Poliklinik fur Frauenheilkunde und Geburtshilfe, Fetscherstrasse 74, D-01307 Dresden, Germany. ; Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Pfotenhauerstrasse 108, D-01307 Dresden, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Separation ; GTPase-Activating Proteins/chemistry/genetics/*physiology ; Gene Duplication ; *Gene Expression Regulation, Developmental ; Humans ; Lateral Ventricles/cytology ; Mice ; Neocortex/cytology/*embryology/metabolism ; Neural Stem Cells/*cytology/metabolism ; Neurogenesis/*genetics ; Neuroglia/cytology/metabolism ; Neurons/cytology/metabolism ; Protein Structure, Tertiary ; Transcriptome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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