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  • 1
    ISSN: 1432-041X
    Keywords: Drosophila ; Collagen ; Haemocytes ; Basement membranes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We report a direct examination of the expression of one collagen gene (DCg1) during Drosophila melanogaster metamorphosis, based on data from in situ hybridization. The transcripts of this gene, thought to encode a basement membrane type IV collagen, are mainly accumulated during ecdysis in wandering haemocytes. Our results demonstrate that haemocytes contribute to extracellular matrix deposition and seem to perform a fibroblastic function during Drosophila development.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-041X
    Keywords: Type IV collagen ; Drosophila ; Germ band retraction ; Dorsal closure ; Nerve cord condensation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A collagen gene (Dcg1) was characterized in Drosophila melanogaster and shown to encode a peptide related to vertebrate basement membrane type IV collagen chains. To study the function of type IV collagen during Drosophila development, we transformed flies with a partially truncated Dcg1 gene under the control of a heat-shock promotor. This construct induced synthesis of shortened pro-α chains which associated with normal ones and thereby caused degradation of the shortened and normal pro-α chains through a process called “pro-collagen suicide”. A large proportion of embryos expressing the transgene developed a phenotype exhibiting absence or partial retraction of the germ band with defects in nerve cord condensation and dorsal closure. Together these results indicated that, during embryogenesis, type IV collagen was an essential guiding factor for cell-matrix interactions in morphogenetic events.
    Type of Medium: Electronic Resource
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