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  • 1
    ISSN: 1591-9528
    Keywords: Renin ; Endotoxin Shock ; Orthostatic Shock ; Glucocorticoids ; Renin ; Endotoxin-Schock ; Orthostase ; Glucocorticoid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Sowohl im Endotoxinschock als auch unter orthostatischer Belastung kam es beim wachen Kaninchen zu einem deutlichen Anstieg der Plasma-Renin-Aktivität. Unter hohen Glucocorticoid-Dosen, die 5 min nach Endotoxin verabreicht wurden, normalisierte sich die Plasma-Renin-Aktivität innerhalb von 4 Std. Unter orthostatischer Belastung war mit der gleichen Glucocorticoid-Dosis keine statistisch gesicherte Wirkung auf den Anstieg der Plasma-Renin-Aktivität erreichbar.
    Notes: Summary The plasma-renin-activity was significantly increased in endotoxin as well as orthostatic shock in unanaesthesized rabbits. High doses of glucocorticoids, administered 5 min after the endotoxin-injection, normalized the plasma-renin-activity after 4 hrs. In orthostatic shock the same doses of glucocorticoids had only a mild effect on the increase of plasma-renin-activity, which was not of statistical significance.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-198X
    Keywords: Key words Nephrotic syndrome ; Glucocorticoid receptors ; Glucocorticoids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The variable response of patients with idiopathic nephrotic syndrome (NS) to glucocorticoid (GC) treatment has not been explained. Earlier studies indicated that the response is limited by cellular GC receptors. We investigated these receptors in mononuclear leukocytes of 28 pediatric patients with NS divided into three groups: steroid-sensitive in relapse, steroid-sensitive in remission, and steroid-resistant. Density and binding affinity of GC receptors were determined by a dexamethasone binding assay; no significant differences were found between the three patient groups and between these and healthy controls, although a few patient values fell outside the range of controls. Total and free plasma concentrations of cortisol were low in all three patient groups. A weak positive correlation was found between the number of GC receptors and total plasma cortisol (r=0.36, P=0.03). The results suggest that factors other than GC receptors that mediate the cellular effects of GC are involved in the variable response of NS patients to GC.
    Type of Medium: Electronic Resource
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