Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: POPULATION ; HEALTH ; POLYPHENOLS ; UNITED-STATES ; ALCOHOL-CONSUMPTION ; ADULTS ; CARDIOVASCULAR RISK ; RECALL COHORT ; CATECHIN INTAKE ; SOFT PROGRAM
    Abstract: A greater adherence to the traditional Mediterranean (MED) diet is associated with a reduced risk of developing chronic diseases. This dietary pattern is based on higher consumption of plant products that are rich in flavonoids. We compared the total flavonoid dietary intakes, their food sources and various lifestyle factors between MED and non-MED countries participating in the EPIC study. Flavonoid intakes and their food sources for 35 628 subjects, aged 35-74 years and recruited between 1992 and 2000, in twenty-six study centres were estimated using standardised 24 h dietary recall software (EPIC-Soft (R)). An ad hoc food composition database on flavonoids was compiled using analytical data from the United States Department of Agriculture and Phenol-Explorer databases. Moreover, it was expanded to include using recipes, estimations of missing values and flavonoid retention factors. No significant differences in total flavonoid mean intake between non-MED countries (373.7 mg/d) and MED countries (370.2 mg/d) were observed. In the non-MED region, the main contributors were proanthocyanidins (48.2 %) and flavan-3-ol monomers (24.9 %) and the principal food sources were tea (25.7 %) and fruits (32.8 %). In the MED region, proanthocyanidins (59.0 %) were by far the most abundant contributor and fruits (55.1 %), wines (16.7 %) and tea (6.8 %) were the main food sources. The present study shows similar results for total dietary flavonoid intakes, but significant differences in flavonoid class intakes, food sources and some characteristics between MED and non-MED countries. These differences should be considered in studies about the relationships between flavonoid intake and chronic diseases.
    Type of Publication: Journal article published
    PubMed ID: 22980437
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: CANCER ; COHORT ; RISK ; IMPACT ; CARCINOGENESIS ; BIOMARKERS ; ASSOCIATION ; polymorphism ; POLYMORPHISMS ; VARIANTS ; HEALTH ; PLASMA ; AGE ; colorectal cancer ; smoking ; COLORECTAL-CANCER ; FIBER ; COLON-CANCER ; MASS-SPECTROMETRY ; EPIC ; nutrition ; education ; NESTED CASE-CONTROL ; physical activity ; ONCOLOGY ; case-control study ; REGRESSION ; ASSOCIATIONS ; VARIANT ; PHYSICAL-ACTIVITY ; biomarker ; methods ; dietary patterns ; GENOTYPE ; LOCUS ; prospective ; CANCER-RISK ; nested case-control study ; COMMON MUTATION ; MTHFR POLYMORPHISMS ; FOLIC-ACID ; Genetic ; FOLATE STATUS ; METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISM ; nested case control study ; C677T MTHFR POLYMORPHISM ; CARBON METABOLIC PATHWAY ; HUMAN METHIONINE SYNTHASE
    Abstract: Background: A potential dual role of folate in colorectal cancer (CRC) is currently subject to debate. We investigate the associations between plasma folate, several relevant folate-related polymorphisms, and CRC risk within the large European Prospective Investigation into Cancer and Nutrition cohort. Methods: In this nested case-control study, 1,367 incident CRC cases were matched to 2,325 controls for study center, age, and sex. Risk ratios (RR) were estimated with conditional logistic regression and adjusted for smoking, education, physical activity, and intake of alcohol and fiber. Results: Overall analyses did not reveal associations of plasma folate with CRC. The RR (95% confidence interval; P-trend) for the fifth versus the first quintile of folate status was 0.94 (0.74-1.20; 0.44). The polymorphisms MTHFR677C -〉 T, MTHFR1298A -〉 C, MTR2756A -〉 G, MTRR66A -〉 G, and MTHFD11958G -〉 A were not associated with CRC risk. However, in individuals with the lowest plasma folate concentrations, the MTHFR 677TT genotype showed a statistically nonsignificant increased CRC risk [RR (95% CI; P-trend) TT versus CC = 1.39 (0.87-2.21); 0.12], whereas those with the highest folate concentrations showed a nonsignificant decreased CRC risk [RR TT versus CC = 0.74 (0.39-1.37); 0.34]. The SLC19A180G -〉 A showed a positive association with CRC risk [RR AA versus GG 1.30 (1.06-1.59); 〈0.01]. Conclusions: This large European prospective multicenter study did not show an association of CRC risk with plasma folate status nor with MTHFR polymorphisms. Impact: Findings of the present study tend to weaken the evidence that folate plays an important role in CRC carcinogenesis. However, larger sample sizes are needed to adequately address potential gene-environment interactions. Cancer Epidemiol Biomarkers Prev; 19(5); 1328-40. (C)2010 AACR
    Type of Publication: Journal article published
    PubMed ID: 20447924
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...