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  • 1
    Keywords: SPECTRA ; BLOOD ; neoplasms ; CLASSIFICATION ; GENERATION ; RISK ; RNA ; PATIENT ; INFECTION ; LIVER-TRANSPLANTATION ; ASSOCIATION ; antibodies ; antibody ; virus ; NO ; LYMPHOMA ; MALIGNANCIES ; AGE ; etiology ; LYMPHOCYTES ; case-control studies ; PREVALENCE ; immunosuppression ; B-CELL LYMPHOMA ; HEMOPHILIA ; NON-HODGKINS-LYMPHOMA ; ELISA ; MALIGNANCY ; REGRESSION ; ASSOCIATIONS ; GRADE ; HCV ; hepatitis C ; LYMPHOPROLIFERATIVE DISORDERS ; MALIGNANT-LYMPHOMA ; MIXED CRYOGLOBULINEMIA ; REARRANGEMENT ; RECIPIENTS
    Abstract: Hepatitis C virus (HCV) has been implicated in the etiology of malignant lymphomas. We estimated the risk of lymphoma associated with detection of HCV infection. Cases (n = 529) were consecutive patients newly diagnosed with a lymphoid malignancy between 1998 and 2002 in 4 centers in Spain. Lymphomas were diagnosed and classified using the WHO Classification. Controls (n = 600) were hospitalized patients matched to the cases by 5-year age group, gender and study center. Several medical conditions associated with severe immunosuppression precluded the eligibility of controls. Patients underwent a personal interview and blood sampling. HCV positive subjects were considered those with antibody response to third generation ELISA or detection of HCV RNA with Amplicor 2.0. Cases were systematically tested for HIV antibodies. We used the chi(2) test and unconditional logistic regression to estimate the odds ratio (OR) and 95% confidence interval (95%. Cl) for lymphoma associated with HCV. HCV infection was detected in 40 cases (73%) and 23 (3.8%) control subjects. Six of 16 patients with HIV-related lymphomas and 4 of 8 organ-recipient-related lymphomas were HCV positive. The analysis, excluding HIV-infected subjects and organ recipients, led to a prevalence of HCV of 5.9% among cases and 3.8% among controls. The age-, gender- and center-adjusted OR for all lymphomas was 1.58 (95% Cl = 0.89-2.79). Among all lymphoma categories, HCV was associated with an increased risk of low grade B-cell lymphomas not otherwise specified (NOS) (OR = 35.98, 95% Cl = 4.70-275.4). A 2-fold excess risk associated to HCV was observed for marginal B-cell lymphomas, diffuse large B-cell lymphoma and lymphoma B NOS but the associations were not statistically significant. HCV infection is associated with an increased risk of a broad spectrum of lymphoid neoplasms among non severely immunocompromised subjects in Spain. (C) 2004 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 15185347
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  • 2
    ISSN: 1439-6327
    Keywords: Heart Rate ; Body Temperature ; Exercise ; Fréquence cardiaque ; Température corporelle ; Exercice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'évolution comparée de la fréquence cardiaque et de la tempërature corporelle est mesurée chez 23 sujets effectuant des exercices musculaires d'une durée d' 1/2 H, avec un métabolisme d'environ 1 L O2/min, à température très élevée (ts 46 °C; th 35 °C). La relation qui unit ces deux paramètres est linéaire tout au moins pour la partie moyenne du diagramme. Pour les valeurs plus faibles, en-dessous de 100 pulsations/min, la fréquence cardiaque est influencée de façon variable par la température corporelle. Au-delà de 170 pulsations/min, la fréquence cardiaque, approchant de sa valeur maximum, n'est plus fonction de l'hyperthermie. L'amplitude de la réaction cardiaque présente de grandes variations individuelles. En moyenne, une élévation de température interne de 1 °C entraîne une accélération cardiaque de 32,3 pulsations/min, cependant, les extrêmes s'étendent de 21 à 46 pulsations/min. La linéarité de la relation justifie l'emploi de la fréquence cardiaque comme témoin d'une surcharge thermique pendant le travail musculaire à haute température. Le comportement individuel est un reflet de l'aptittide de chaque sujet à supporter les températures élevées.
    Notes: Summary Heart rate and body temperature were measured in 23 men walking on a treadmill during 1/2 an hour in a very hot environment (ta 46 °C; twb 35 °C), with an energy expenditure of about 11 O2/min. A linear relationship was found between the two parameters, at least for the middle part of the diagram. For lower values, below 100 beats/min, heart rate is influenced in a variable manner by the body temperature. Above 170 beats/min, heart rate approaches its highest value, and is hence no more influenced by hyperthermy. From one subject to another, the extent of cardiac reaction varies considerabily. On the average, when body temperature increases by 1 °C, heart rate increases by 32,3 beats/min, but extreme values are 21 and 46 beats/min. The linearity of the diagram justifies the use of heart rate as a reference of a thermal overloading during muscular exercise in hot environment. The individual comportment truly reflects each subject's capacity in bearing hot climates.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1439-6327
    Keywords: Beta-Adrenergic Blockade ; Heart Rate ; Submaximum and Maximum Exercice ; Bêta-bloqueur ; Fréquence cardiaque ; Exercice submaximum et maximum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Resume L'effet d'un bêta-bloqueur sur la réponse cardiaque d'exercice a été vérifié chez 7 jeunes adultes sains. L'ingestion de 80 mg de propranolol entraîne une diminution significative de la fréquence cardiaque à tous les niveaux métaboliques avec d'importantes variations individuelles. Cette modification circulatoire réduit la tolérance à l'exercice musculaire et fait baisser la consommation maximum d'O2, en moyenne de 15,5%.
    Notes: Summary The effect of Beta-adrenergic blockade on the circulatory response has been verified during muscular exercise on 7 healthy young men. The administration of 80 mg propranolol induced a significant decrease in cardiac frequency to each metabolic level, however, with an important individual variation. This modification of the circulation reduces the tolerance to muscular exercise and the maximum oxygen consumption (mean: 15.5%).
    Type of Medium: Electronic Resource
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