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  • 78.20  (1)
  • Hodgkin's disease  (1)
  • Key Words: Variscan basement, 3-D wide-angle data, DEKORP, deep seismic sounding, crustal structure, prestack-migration.  (1)
  • 1995-1999  (3)
  • 1975-1979
Collection
Keywords
Publisher
Years
  • 1995-1999  (3)
  • 1975-1979
Year
  • 1
    ISSN: 1569-8041
    Keywords: autologous stem-cell transplantation ; chemotherapy ; Hodgkin's disease ; relapses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Despite high-dose therapy and ASCT some patients with aggressive HD fail to achieve long-term survival. Patients and methods: Forty-three patients with induction failure (n = 19) or very unfavorable (UF) relapse (n = 24) from HD were included in a multicentric study of tandem ASCT. They planned to receive two courses of IVA75 with GCSF and blood stem-cell collection. ASCT1 was conditionned with CBV + mitoxantrone (30 mg/m2) and ASCT2 (cytarabine 6 g/m2, melphalan 140 mg/m2 and total body irradiation at 12 Gy or busulfan 16 (n = 4) than 12 mg/kg). After salvage therapy, response 〉50% was observed in 63% of the patients (six patients were included for refractory relapse). Four patients had no ASCT for disease progression; seven patients had only ASCT1 (disease progression, n = 3) and thirty-two patients (74%) received the two ASCT. Results: Hematologic recovery was normal after ASCT1 but delayed platelet recovery was observed after ASCT2 with busulfan in the conditioning regimen. Two VOD with one fatal occured with busulfan at 16 mg/kg and one hemorragic cystis, no further grade 4 toxicity was observed with the reduced doses of busulfan (12 mg/kg). After ASCT2, 83% of these UF patients were in remission and 20% relapsed within the first year. On an intent-to-treat analysis, 22 of 43 patients are in continuous CR (including 8 patients with induction failure). For the whole population (n = 43) and for patients receiving the two ASCT (n = 32), the two-year survival from the date of progression were respectively at 65% and at 74%. Conclusion: double ASCT is feasible in very UF relapse from HD and may lead to some prolonged remission.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1420-9136
    Keywords: Key Words: Variscan basement, 3-D wide-angle data, DEKORP, deep seismic sounding, crustal structure, prestack-migration.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —In addition to the near normal-incidence observations within the German DEKORP 2 project in 1984, wide-angle observations have been carried out on a parallel profile across the boundary between the Saxothuringian and Moldanubian crust, approximately 50 km NE of the main transect to control three-dimensional variations. Explosion sources have been used for the entire survey, providing excellent conditions for wide-angle registrations. A velocity model has been derived on the basis of in- and off-line refraction measurements using a kinematic raytracer which was extended to three dimensions by interpolation of 2-D velocity fields between parallel sections. Although prestack-migration of the data led to aliasing effects due to large shot and geophone spacing, stable results were obtained by forming envelopes after single-shot migration. The migrated sections reveal a strongly reflective Moho at about 31 km depth and a steeply (50°) dipping intracrustal reflector, which seems to be related to the border between the two Variscan units.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 61 (1995), S. 89-93 
    ISSN: 1432-0649
    Keywords: 61.70 ; 72.20 ; 78.20
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In LiNbO3:Fe,Me crystals (Me = K, Mg, Zn) elementary holograms are recorded and erased with frequency-doubled, ordinarily polarized pulses of a Q-switched Nd:YAG laser. At high light intensities (I 〉 109 Wm−2) holographic sensitivities and saturation values of refractive index changes grow with increasing intensity and a contribution to photo-conductivity appears increasing quadratically withI. The intensity-dependent parts of the holographic quantities are diminished by increasing the lithium content of the samples or by doping the crystals with magnesium or zinc. Experimental results can be described by a two-center charge transport model, which is the Fe2+/3+ model supplemented by shallow traps, namely niobium ions occupying lithium sites.
    Type of Medium: Electronic Resource
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