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  • 1
    ISSN: 1573-0832
    Keywords: Human PMN ; H. capsulatum ; fungicidal resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The basis for resistance of yeast form of Histoplasma capsulatum to antifungal activity of human neutrophils was studied. In limiting dilution assays and short term coculture assays human neutrophils were ineffective in killing H. capsulatum whereas Candida albicans was readily killed. By contrast, in a cell free hydrogen peroxide-peroxidase-halide system H. capsulatum was as sensitive to killing as C. albicans. Moreover, lysate of human neutrophils effectively substituted for horse-radish peroxidase in a cell free system for killing H. capsulatum. H. capsulatum elicited significant products of the oxidative burst in human neutrophils as detected by luminol-enhanced chemiluminescence. However, the response was two-fold less (p〈0.05) than that induced by C. albicans. Transmission electron microscopy studies showed that phagosome-lysosome fusion took place when neutrophils phagocytosed C. albicans or H. capsulatum. Taken together, these findings indicate that, even though H. capsulatum elicits an oxidative burst and phagosome-lysosome fusion within the phagosome, it is capable of evading damage in short term assays.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 137 (1973), S. 167-175 
    ISSN: 1432-0878
    Keywords: Leydig cells ; Mouse ; Ring-shaped nucleolus ; Endoplasmic reticulum ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Many mature Leydig cells of adult mice contain annular nucleoli. In the cytoplasm of these cells, there is an abundance of agranular endoplasmic reticulum and its modifications, i.e. membranous whorls and double-walled tubules. By contrast, the cytoplasm of Leydig cells with compact nucleoli shows abundant free ribosomes and granular endoplasmic reticulum. It is assumed that the granular endoplasmic reticulum shifts to the agranular endoplasmic reticulum and its modifications during the differentiation of the Leydig cell. For the maturation of the Leydig cell the annular nucleoli may play an important role.
    Type of Medium: Electronic Resource
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