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  • MIXED CRYOGLOBULINEMIA  (3)
  • INFECTION  (2)
  • 1
    Keywords: SPECTRA ; BLOOD ; neoplasms ; CLASSIFICATION ; GENERATION ; RISK ; RNA ; PATIENT ; INFECTION ; LIVER-TRANSPLANTATION ; ASSOCIATION ; antibodies ; antibody ; virus ; NO ; LYMPHOMA ; MALIGNANCIES ; AGE ; etiology ; LYMPHOCYTES ; case-control studies ; PREVALENCE ; immunosuppression ; B-CELL LYMPHOMA ; HEMOPHILIA ; NON-HODGKINS-LYMPHOMA ; ELISA ; MALIGNANCY ; REGRESSION ; ASSOCIATIONS ; GRADE ; HCV ; hepatitis C ; LYMPHOPROLIFERATIVE DISORDERS ; MALIGNANT-LYMPHOMA ; MIXED CRYOGLOBULINEMIA ; REARRANGEMENT ; RECIPIENTS
    Abstract: Hepatitis C virus (HCV) has been implicated in the etiology of malignant lymphomas. We estimated the risk of lymphoma associated with detection of HCV infection. Cases (n = 529) were consecutive patients newly diagnosed with a lymphoid malignancy between 1998 and 2002 in 4 centers in Spain. Lymphomas were diagnosed and classified using the WHO Classification. Controls (n = 600) were hospitalized patients matched to the cases by 5-year age group, gender and study center. Several medical conditions associated with severe immunosuppression precluded the eligibility of controls. Patients underwent a personal interview and blood sampling. HCV positive subjects were considered those with antibody response to third generation ELISA or detection of HCV RNA with Amplicor 2.0. Cases were systematically tested for HIV antibodies. We used the chi(2) test and unconditional logistic regression to estimate the odds ratio (OR) and 95% confidence interval (95%. Cl) for lymphoma associated with HCV. HCV infection was detected in 40 cases (73%) and 23 (3.8%) control subjects. Six of 16 patients with HIV-related lymphomas and 4 of 8 organ-recipient-related lymphomas were HCV positive. The analysis, excluding HIV-infected subjects and organ recipients, led to a prevalence of HCV of 5.9% among cases and 3.8% among controls. The age-, gender- and center-adjusted OR for all lymphomas was 1.58 (95% Cl = 0.89-2.79). Among all lymphoma categories, HCV was associated with an increased risk of low grade B-cell lymphomas not otherwise specified (NOS) (OR = 35.98, 95% Cl = 4.70-275.4). A 2-fold excess risk associated to HCV was observed for marginal B-cell lymphomas, diffuse large B-cell lymphoma and lymphoma B NOS but the associations were not statistically significant. HCV infection is associated with an increased risk of a broad spectrum of lymphoid neoplasms among non severely immunocompromised subjects in Spain. (C) 2004 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 15185347
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  • 2
    Keywords: Germany ; human ; MODEL ; EXPOSURE ; HEPATOCELLULAR-CARCINOMA ; HISTORY ; RISK ; RNA ; INFECTION ; FAMILY ; T cell ; T-CELL ; ASSOCIATION ; POLYMORPHISMS ; virus ; LYMPHOMA ; MALIGNANCIES ; AGE ; family history ; etiology ; COUNTRIES ; leukemia ; PATHOGENESIS ; REPLICATION ; case-control studies ; INDIVIDUALS ; PREVALENCE ; INTERVIEW ; MULTICENTER ; B-CELL LYMPHOMA ; immunoassay ; NON-HODGKINS-LYMPHOMA ; SERUM ; MALIGNANCY ; case-control study ; RE ; FAMILIES ; VIRUS-INFECTION ; LYMPHOPROLIFERATIVE DISORDERS ; MIXED CRYOGLOBULINEMIA ; METAANALYSIS ; case control studies ; INTERVAL ; ENZYME ; SUBTYPES ; LYMPHOMAS ; SIZE ; FAMILY-HISTORY ; EUROPEAN COUNTRIES ; odds ratio ; B-CELL ; EXPOSURES ; MULTICENTER CASE-CONTROL ; RARE ; SAMPLE-SIZE ; HCV INFECTION
    Abstract: Background & Aims: Increasing evidence points toward a role of hepatitis C virus (HCV) infection in the etiology of malignant lymphomas. However, previous epidemiologic studies were limited in size to establish an association between HCV infection and specific lymphoma subtypes. We performed a large, multicenter, case-control study to address this question. Methods: The study comprised 5 European countries and included newly diagnosed cases of any lymphoid malignancy recruited between 1998 and 2004. Controls were matched to cases by 5-year age group, sex, and study center. In-person interviews were conducted to collect data on demographic, medical, and family history as well as environmental exposures. Serum samples of 1807 cases and 1788 controls (excluding human immunodeficiency virus-positive and organ-transplantation subjects) were screened for HCV infection using an enzyme immunoassay. Positive as well as randomly selected negative samples were subjected to HCV RNA detection and HCV genotyping. Results: HCV infection was detected in 53 (2.9%) lymphoma cases and in 41 (2.3%) control subjects (odds ratio [OR], 1.42; 95% confidence interval [CI]: 0.93-2.15). Restricted to individuals who tested positive for HCV-RNA (indicating persistent infection and active viral replication), the OR was 1.82 (95% CI: 1.13-2.91). In subtype-specific analyses, HCV prevalence was associated with diffuse large B-cell lymphoma (OR, 2.19; 95% CI: 1.23-3.91) but not with chronic lymphocytic leukemia or follicular, Hodgkin's, or T-cell lymphoma. The sample size was not sufficient to derive any conclusions for rare lymphoma entities such as splenic marginal zone lymphoma. Conclusions: These results support a model that chronic HCV replication contributes to lymphomagenesis and establish a specific role of HCV infection in the pathogenesis of diffuse large B-cell lymphoma
    Type of Publication: Journal article published
    PubMed ID: 17087949
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  • 3
    ISSN: 1573-2568
    Keywords: HEPATITIS C ; VIRUS ; HEPATIC NON-HODGKIN'S LYMPHOMA ; MIXED CRYOGLOBULINEMIA ; PERIPHERAL MONONUCLEAR BLOOD CELLS ; LATENCY ; LYMPHOPROLIFERATIVE DISORDERS ; VIRUS-HOST INTERACTION
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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