Key words Erythropoietin
Springer Online Journal Archives 1860-2000
Abstract The aim of our study was to evaluate bone marrow stimulation and bone marrow response to postoperative anaemia in children after open heart surgery. In 16 children (age 5.7 ± 0.9 years, weight 20.1 ± 3.2 kg) serum erythropoietin, haematocrit, reticulocyte count, ferritin, transferrin saturation and C-reactive protein were assessed perioperatively after cardiopumonary bypass for surgical repair of atrial septal defect. Erythropoietin increased seven fold from 14 ± 6.2 (7–30) to 80 ± 49 (20–171) mU/ml (P 〈 0.05) and the reticulocyte count a 1.7-fold from 11.1 ± 3.1 (6–19) to 18.4 ± 5.9 (10–31) ‰ (P 〈 0.05). Transferrin saturation was inversely correlated to C-reactive protein. Conclusion These findings suggest adequate bone marrow stimulation but an inadequate bone marrow response during the immediate perioperative period, caused by inhibition of erythropoesis by acute postoperative inflammation in children after open heart surgery.
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