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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 14 (1986), S. 241-246 
    ISSN: 1434-0879
    Keywords: Seminal fluid ; Biochemical analysis ; Citrate ; Fructose ; Carnitine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The measurement of biochemical markers in human seminal plasma is important in the evaluation of male infertility. We recommend the measurement of one representative substance for each organ involved in seminal fluid production as a routine diagnostic tool: The initial fructose level for seminal vesicular function, citrate or acid phosphatase for the prostate gland and free carnitine as an index of epididymal function. A biochemical analysis of seminal fluid enables us to detect disturbances of the male adnexal organs and may lead to more exact therapy.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-808X
    Keywords: Schlüsselwörter Erektile Dysfunktion ; Ejakulationsstörungen ; Karzinom ; Therapie ; Key words Erectile dysfunction ; Ejaculation disturbances ; Surgery ; Neoplasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Disorders of sexual function are a frequent sequel to the surgical treatment of tumors in men. Operations involving the abdominal cavity, the retroperitoneal space and the true pelvis can damage the nerve and blood supply of the sexual organs, and this may cause dysfunction of the mechanisms of erection and ejaculation. Since it is often a matter of sexually active patients at the reproductive stage of their lives, the prevention of these secondary effects of tumor therapy takes on a special significance. Impairment of the erection mechanism or disturbances of ejaculation may follow the operative, radiological or medical treatment of a variety of tumors. They are a frequent consequence of the treatment of carcinoma of the bladder, prostate, testes, colon or rectum, and are particularly to be feared after radical operations that can damage the integrity of the nerves and vessels of the pelvis and lumbar region, since these are necessary for the physiological function of the sex organs. Today, with a thorough understanding of the neuroanatomy and with modern surgical techniques, these effects are avoidable in a high percentage of cases. If, however, effective treatment of the neoplasm requires such a radical operation that damage to these nerve pathways cannot be avoided, the consequent reduction of the sexual activity and fertility of patients in this age group can seriously impair the quality of their lives. Even so, there are many therapeutic procedures available which make it possible to treat disturbances both of the erection mechanism and of ejaculation in almost all cases.
    Notes: Zusammenfassung Nach tumorchirurgischen Eingriffen im Bauchraum, dem Retroperitoneum und des kleinen Beckens kann es zu einer Schädigung der Nerven und Gefäße der Sexualorgane kommen. Infolge hiervon kommt es häufig zu sexuellen Funktionsstörungen beim Mann. Da es sich oft um Patienten im sexuell aktiven und auch reproduktionsfähigen Alter handelt, wird der Prävention solcher Begleiterscheinungen bei der Tumortherapie besondere Bedeutung geschenkt. Eine Beeinträchtigung der Erektion oder Störungen der Ejakulation können nach operativer, strahlentherapeutischer oder medikamentöser Therapie verschiedener Tumore auftreten. Häufig treten sie bei der Therapie des Harnblasen-, Prostata, Hodenkarzinoms oder kolorektalen Tumoren auf. Durch eingehendes Verständnis der Neuroanatomie und moderne chirurgische Techniken sind diese Störungen heute in einem hohen Prozentsatz vermeidbar. Läßt sich eine Schädigung der entsprechenden Nervenbahnen aufgrund der erforderlichen Radikalität des chirurgischen Eingriffs, um die Tumorerkrankung kurativ zu therapieren, nicht vermeiden, sind sexuelle Funktionsstörungen für diese Patienten im sexuell aktiven und auch reproduktionsfähigen Alter eine deutliche Einschränkung der Lebensqualität. Sowohl Ejakulationsstörungen als auch Erektionsstörungen lassen sich jedoch durch eine Reihe von Therapiemodalitäten in fast allen Fällen behandeln.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1335
    Keywords: Whole blood cell cultures ; Cytokine production ; Urogenital carcinomas ; Immune competence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The production of the cytokines interferon γ (IFN γ), interleukin-1 α (IL-1 α) and tumor necrosis factor α (TNF α) was investigated in the mitogen-stimulated whole blood cell culture media from 51 patients with urinary bladder carcinomas, 52 patients with renal carcinomas, 31 patients with prostatic carcinomas and 360 healthy controls. The cytokines were measured 4 days after induction by a sensitive enzymo-immunological assay. In the blood cell culture supernatants of the patients with urinary bladder carcinomas significancy lower levels of IFN γ (P≤0.001), IL-2 (P≤0.001) and TNFα (P≤0.05) were found as compared to the controls. Blood cells of patients with renal carcinomas had lower production of IFN γ (P≤0.01), IL-2 (P≤0.001) and IL-1α (P≤0.01), whereas the values of the total group of patients with prostatic carcinomas were not significantly different from those of the controls. Lymphocyte and monocyte counts were almost identical in the control and all tumor patient groups. When the patients with renal carcinomas and prostatic carcinomas were analyzed according to their different clinical stages we could show a gradual depression of the IFN-γ levels, which was related to tumor burden.
    Type of Medium: Electronic Resource
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