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  • 1
    ISSN: 1432-1076
    Keywords: Trisomy G-21 ; Phosphofructokinase ; Deficiency in Erythrocytes ; Gene Locus ; Glycerophosphatedehydrogenase ; Erythrocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In den Erythrocyten eines Falles von Trisomie G-21 konnte im Gegensatz zu bisher vorliegenden Berichten eine Verminderung der Aktivität von Phosphofructokinase (PFK) gefunden werden. Daneben wurde eine hohe Aktivität der Glycerophosphatdehydrogenase und in geringerem Ausmaß auch anderer Enzyme nachgewiesen. Die mit dem PFK-Mangel in Zusammenhang stehenden Stoffwechselstörungen sowie die Frage der genetischen Lokalisation dieses Enzyms werden diskutiert.
    Notes: Abstract A deficiency of erythrocyte-phosphofructokinase has been demonstrated in a case of Trisomy-G-21. This is in contrast to findings of other authors who reported an increase of erythrocyte-PFK in cases of Down's syndrome. The metabolic changes caused by PFK deficiency and the problem of genetic localization of this enzyme are discussed. In addition an increased activity of glycerophosphate-dehydrogenase and, to a lesser degree, some other enzyme was found in the patients red blood cells.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2013
    Keywords: Key words Calcium oscillations ; Development ; In situ ; Intracellular calcium ([Ca2+]i) measurement ; Neurons ; Zebrafish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We have developed a non-invasive technique to measure intracellular calcium ([Ca2+]i) in neurons growing within intact embryos of the zebrafish (Danio rerio). A single blastomere was injected with a calcium-sensitive fluorescent dye (Calcium Green dextran) between the 32- and 128-cell stage and the embryo imaged between 16 h and 20 h postfertilisation using laser scanning confocal microscopy. Labelled nerve cells from embryos preinjected with dye and dissociated at 16 h showed a fluorescence increase (66±22%; n=11) in response to depolarisation with KCl confirming that the dye remained intracellular and was sensitive to calcium. In addition, fluorescence changes in activated muscle cells of intact embryos showed that the dye was capable of responding to [Ca2+]i changes in vivo. Imaging of dye loaded cells over 30-min periods in embryos between 16 and 20 h revealed that the majority of neurons within the brain and spinal cord did not show spontaneous fluorescence changes distinguishable from noise. However, a subset of neurons within the ventral spinal cord exhibited spontaneous, repetitive [Ca2+]i oscillations which may have a functional significance during neuronal development.
    Type of Medium: Electronic Resource
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